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vericiguat

CAS No.
1350653-20-1
Chemical Name:
vericiguat
Synonyms
Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate;MK-1242;BAY1021189;vericiguat;Vericiguat Impurity;Vericiguat (BAY 1021189);Inhibitor,BAY-1021189,BAY 1021189,inhibit,Guanylate Cyclase,Vericiguat;methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate (Vericiguat);Carbamic acid, N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester
CBNumber:
CB83033102
Molecular Formula:
C19H16F2N8O2
Molecular Weight:
426.38
MDL Number:
MFCD28502029
MOL File:
1350653-20-1.mol
Last updated:2023-08-14 13:33:12

vericiguat Properties

Boiling point 535.9±50.0 °C(Predicted)
Density 1.63±0.1 g/cm3(Predicted)
solubility DMSO:60.0(Max Conc. mg/mL);140.7(Max Conc. mM)
form A solid
pka 10.61±0.70(Predicted)
FDA UNII LV66ADM269
NCI Drug Dictionary avatrombopag maleate
ATC code C01DX22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H311-H331
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
NFPA 704
0
2 0

vericiguat price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-6981 Vericiguat 99.09% 1350653-20-1 2mg $90 2021-12-16 Buy
ChemScene CS-6981 Vericiguat 99.09% 1350653-20-1 5mg $160 2021-12-16 Buy
ChemScene CS-6981 Vericiguat 99.09% 1350653-20-1 10mg $220 2021-12-16 Buy
ChemScene CS-6981 Vericiguat 99.09% 1350653-20-1 50mg $650 2021-12-16 Buy
ChemScene CS-6981 Vericiguat 99.09% 1350653-20-1 100mg $950 2021-12-16 Buy
Product number Packaging Price Buy
CS-6981 2mg $90 Buy
CS-6981 5mg $160 Buy
CS-6981 10mg $220 Buy
CS-6981 50mg $650 Buy
CS-6981 100mg $950 Buy

vericiguat Chemical Properties,Uses,Production

Description

Vericiguat is a novel oral soluble guanylate cyclase (sGC) stimulator.
- Soluble guanylate cyclase (sGC) is an enzyme that is activated by nitric oxide (NO). The activation initiates a signaling cascade which converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP). cGMP levels increase & protein kinase G (PKG) is activated, resulting in a decrease of intracellular free Ca++ -> vascular smooth muscle cell relaxation.
- However, individuals with HF have reduced NO levels. Vericiguat, as a sGC stimulator, increases the enzymatic activity of sGC to generate cGMP independently of NO and enhances sGC sensitivity to endogenous NO.
Vericiguat is the 2nd drug in this class and follows riociguat ADEMPAS, which has been approved for treating pulmonary arterial hypertension.
SOCRATES-REDUCED was a phase II dose-finding trial of vericiguat in HF-rEF. The primary endpoint, change in NTproBNP over 12 weeks, was not statistically significant compared to placebo. A secondary exploratory analysis suggested a dose-response relationship in which higher doses of vericiguat were associated with greater reductions in NTproBNP levels.

Uses

Vericiguat is a novel oral soluble guanylate cyclase (sGC) stimulator that enhances the cyclic guanosine monophosphate (GMP) production pathway, by directly stimulating soluble guanylate cyclase activity, as well as sensitizing soluble guanylate cyclase to endogenous NO. It was initially developed for potential to reduce mortality and morbidity associated with chronic heart failure with reduced ejection fraction.

Uses

Vericiguat is used on targeting cyclic guanosine monophosphate in the treatment of heart failure.

Definition

ChEBI: Vericiguat is a pyrazolopyridine that is 5-fluoro-1H-pyrazolo[3,4-b]pyridine in which the amino hydrogen at position 1 has been substituted by a 2-fluorobenzyl group and the hydrogen at position 3 has been substituted by a 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. It is a soluble guanylate cyclase stimulator which is used for treatment of chronic heart failure. It has a role as a soluble guanylate cyclase activator, a vasodilator agent and an antihypertensive agent. It is an aminopyrimidine, a pyrazolopyridine, a carbamate ester and an organofluorine compound.

Clinical Use

Vericiguat was advanced to clinical evaluation, as an oral therapy for chronic heart failure, either with reduced ejection fraction (HFrEF), or preserved EF (HFpEF). In mid-June 2020 Merck announced that the FDA had granted priority review status to vericiguat and based on this. The FDA approved vericiguat in January 2021, to reduce the risk of cardiovascular death, heart failure re-hospitalisation, or the requirement for outpatient intravenous diuretics, in patients with symptomatic chronic heart failure and ejection fraction less than 45%. This approval was based on efficacy data arising from the Phase 3 trial NCT02861534 (a.k.a. the VICTORIA trial).

vericiguat Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 131)Suppliers
Supplier Tel Email Country ProdList Advantage
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 8136 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shenzhen Shengda Pharma Limited
755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Hangzhou Huarong Pharm Co., Ltd.
571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58
Henan Alfa Chemical Co., Ltd
+8618339805032 alfa4@alfachem.cn China 12759 58
Wuhan Demeikai Biotechnology Co., Ltd
+8618942921723 info@dmksw.xin China 723 58

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View Lastest Price from vericiguat manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vericiguat pictures 2024-03-12 Vericiguat
1350653-20-1
US $0.00 / g 1g 98% HPLC 100kg shandong perfect biotechnology co.ltd
Vericiguat pictures 2023-11-01 Vericiguat
1350653-20-1
US $0.00-0.00 / KG 1KG 99% 200 Hangzhou ICH Biofarm Co., Ltd
Vericiguat pictures 2021-09-15 Vericiguat
1350653-20-1
US $0.00 / KG 1KG 99% 500KG Hangzhou Huarong Pharm Co., Ltd.
  • Vericiguat pictures
  • Vericiguat
    1350653-20-1
  • US $0.00 / g
  • 98% HPLC
  • shandong perfect biotechnology co.ltd
  • Vericiguat pictures
  • Vericiguat
    1350653-20-1
  • US $0.00-0.00 / KG
  • 99%
  • Hangzhou ICH Biofarm Co., Ltd
  • Vericiguat pictures
  • Vericiguat
    1350653-20-1
  • US $0.00 / KG
  • 99%
  • Hangzhou Huarong Pharm Co., Ltd.
vericiguat BAY1021189 Carbamic acid, N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester Vericiguat (BAY 1021189) MK-1242 methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate (Vericiguat) Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate Inhibitor,BAY-1021189,BAY 1021189,inhibit,Guanylate Cyclase,Vericiguat Vericiguat Impurity 1350653-20-1 C19H16F2N8O2 API