ChemicalBook >> CAS DataBase List >>PF-5006739
PF-5006739
- CAS No.
- 1293395-67-1
- Chemical Name:
- PF-5006739
- Synonyms
- PF-5006739;PF 5006739;PF5006739;PF-5006739 >=98% (HPLC);4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine;4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine;2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-
- CBNumber:
- CB83039225
- Molecular Formula:
- C22H22FN7O
- Molecular Weight:
- 419.45
- MDL Number:
- MFCD28386023
- MOL File:
- 1293395-67-1.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | UN 2811 6.1 / PGIII |
PF-5006739 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0246 | PF-5006739 ≥98% (HPLC) | 1293395-67-1 | 5MG | $102 | 2022-05-15 | Buy |
| Sigma-Aldrich | PZ0246 | PF-5006739 ≥98% (HPLC) | 1293395-67-1 | 25MG | $410 | 2022-05-15 | Buy |
| Tocris | 6346 | PF5006739 ≥98%(HPLC) | 1293395-67-1 | 25 | $266 | 2021-12-16 | Buy |
| Tocris | 6346 | PF5006739 ≥98%(HPLC) | 1293395-67-1 | 5 | $68 | 2021-12-16 | Buy |
| TRC | P294150 | PF5006739 | 1293395-67-1 | 1mg | $65 | 2021-12-16 | Buy |
PF-5006739 Chemical Properties,Uses,Production
Biochem/physiol Actions
PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 values of 3.9 nM for CK1δ and 17.0 nM for CK1ε) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model.
storage
Store at +4°C
PF-5006739 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-5006739 Suppliers
Global( 19)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Hangzhou ChangCun Biotechnology Co., Ltd. | 0571-; 13567100326 | 158848739@qq.com | China | 108 | 50 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8018 | 62 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
PF-5006739
PF-5006739 >=98% (HPLC)
2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-
PF 5006739;PF5006739
4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine
4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine
1293395-67-1