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PFI-2 (hydrochloride)

PFI-2 (hydrochloride) structure

CAS No.: 1627607-87-7

Chemical Name:: PFI-2 (hydrochloride)

Synonyms: (R)-PFI-2;PFI-2 HCl salt;PFI-2 (hydrochloride);(R)-PFI-2 (hydrochloride);PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2;(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride;(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride;macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride

CBNumber:: CB83041444

Molecular Formula:: C23H26ClF4N3O3S

Molecular Weight:: 535.98

MDL Number:: MFCD28133380

MOL File:: 1627607-87-7.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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PFI-2 (hydrochloride) Properties

Melting point	>209°C (dec.)
storage temp.	2-8°C
solubility	Soluble in DMSO (up to at least 25 mg/ml)
form	powder
color	white to beige
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301+P312+P330

PFI-2 (hydrochloride) price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1408	(R)-PFI-2 ≥97% (HPLC)	1627607-87-7	5mg	$196	2024-03-01	Buy
Sigma-Aldrich	SML1408	(R)-PFI-2 ≥97% (HPLC)	1627607-87-7	25mg	$769	2024-03-01	Buy
Cayman Chemical	14678	(R)-PFI-2 (hydrochloride) ≥95%	1627607-87-7	1mg	$57	2024-03-01	Buy
Cayman Chemical	14678	(R)-PFI-2 (hydrochloride) ≥95%	1627607-87-7	5mg	$179	2024-03-01	Buy
Cayman Chemical	14678	(R)-PFI-2 (hydrochloride) ≥95%	1627607-87-7	10mg	$330	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1408	5mg	$196	Buy
SML1408	25mg	$769	Buy
14678	1mg	$57	Buy
14678	5mg	$179	Buy
14678	10mg	$330	Buy

PFI-2 (hydrochloride) Chemical Properties,Uses,Production

Description

SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the transcription factor TAF10. (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC₅₀ = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases. Its enantiomer, (S)-PFI-2 , is 500-fold less active (IC₅₀ = 1 μM). See the Structural Genomics Consortium (SGC) website for more information.

Uses

(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide Hydrochloride known as (-)-PFI-2 HCl is a cell permeable inhibitor of SET Domain-Containing protein 7/9 (SET 7/9) which plays a role in tumorigenesis in cell cancer lines.

Biochem/physiol Actions

(R)-PFI-2 is a histone-lysine N-methyltransferase (HKMT) inhibitor selective for SETD7 (also known as SET9). (R)-PFI-2 has an IC50 value of 2 nM and 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. For full characterization details, please visit the PFI-2 probe summary on the Structural Genomics Consortium (SGC) website.(S)-PFI-2, an enantiomer of (R)-PFI-2, is used as a negative control. (S)-PFI-2 is available from Sigma. To learn more about and purchase (S)-PFI-2, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at -20°C

References

1)?Barsyte-Lovejoy?et al.?(2014),?(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells;?Proc. Natl. Acad. Sci. USA?111?12853

PFI-2 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

PFI-2 (hydrochloride) Suppliers

Global( 69)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Baoji Guokang Bio-Technology Co., Ltd.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from PFI-2 (hydrochloride) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-13	PFI-2 hydrochloride 1627607-87-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2021-07-09	PFI-2 hydrochloride 1627607-87-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

PFI-2 hydrochloride
1627607-87-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

PFI-2 hydrochloride
1627607-87-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

PFI-2 (hydrochloride) Spectrum

PFI-2 (hydrochloride)(1627607-87-7)¹HNMR

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1of2

PFI-2 (hydrochloride) PFI-2 HCl salt (R)-PFI-2 (hydrochloride) (R)-PFI-2 PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2 (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride 1627607-87-7 C23H25F4N3O3SHCl C23H26ClF4N3O3S API