Simeprevir sodium
- CAS No.
- 1241946-89-3
- Chemical Name:
- Simeprevir sodium
- Synonyms
- Olysio;Simeprevir sodium;TMC 435 sodium salt
- CBNumber:
- CB83043307
- Molecular Formula:
- C38H47N5O7S2.x(Na)
- Molecular Weight:
- 773.94
- MDL Number:
- MFCD30724946
- MOL File:
- 1241946-89-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Simeprevir (sodium salt) | 22144 | 1mg | $44 |
| Simeprevir (sodium salt) | 22144 | 25mg | $638 |
| Simeprevir (sodium salt) | 22144 | 5mg | $151 |
| Simeprevir (sodium salt) | 22144 | 10mg | $278 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.43(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) |
| form | A crystalline solid |
| FDA UNII | 16U7H60184 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H334-H317-H341-H361-H370-H335-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P301+P312-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P330-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
Simeprevir sodium price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 25mg | $638 | 2024-03-01 | Buy |
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 10mg | $278 | 2024-03-01 | Buy |
Simeprevir sodium Chemical Properties,Uses,Production
Description
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Uses
Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][4].
in vivo
Simeprevir (TMC435) has moderate terminal elimination half-life (t1/2=1.5 h and 4.1 h for rat (3 mg/kg, p.o.), monkey (3 mg/kg, p.o.))[3].
Simeprevir (TMC435350) exhibits a medium-slow rate of absorption, well distribution with the high concentration observed in the liver, and a low clearance[1].
Pharmacokinetic Parameters of Simeprevir (TMC435350) in male Sprague-Dawley rats[1].
| IV (2 mg/kg) | PO (10 mg/kg) | |
| CL (L/h/kg) | 0.505 | |
| Vdss (h) | 0.49 | |
| AUC0-24 (μM·h) | 5.21 | 2.79 |
| Cmax (μM) | 0.73 | |
| Tmax (h) | 3.0 | |
| T1/2 (h) | 2.8 | |
| F (%) | 11 | |
| Liver/plasma ratio at 6 h | 63.5 | 32 |
| Animal Model: | Sprague-Dawley (SD) rats and cynomolgus monkeys[3] |
| Dosage: | 3 mg/kg |
| Administration: | PO; single dosage |
| Result: | Time at which peak concentration (Tmax) of 1 hour and 2 hour for rat and monkey, respectively. Concentration at 24 h after dosing (C24 h) of 0.9 and 2.3 ng/mL for rat and monkey, respectively. AUC0-24h=1173 and 1409 ng·h/mL for rat and monkey, respectively. |
References
[1] Raboisson P, et al. Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. DOI:10.1016/j.bmcl.2008.07.088
[2] Lin TI, et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85. Epub 2009 Jan 26. DOI:10.1128/AAC.01058-08
[3] Rajagopalan R, et al. Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease. Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01569-16. DOI:10.1128/AAC.01569-16
[4] Lo HS, et al. Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci. 2021 May 26;7(5):792-802. DOI:10.1021/acscentsci.0c01186
Simeprevir sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 | sales@sjar-tech.com | China | 504 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15086 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Chongqing jooe co., ltd | +undefined86-15223382610 | info@jooe.com | China | 6258 | 58 |
View Lastest Price from Simeprevir sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-05 | Simeprevir sodium
1241946-89-3
|
US $159.00-987.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-09-11 | Simeprevir Sodium
1241946-89-3
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
-
- Simeprevir sodium
1241946-89-3
- US $159.00-987.00 / mg
- TargetMol Chemicals Inc.
-
- Simeprevir Sodium
1241946-89-3
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
