ChemicalBook >> CAS DataBase List >>GSK2256294A
GSK2256294A
- CAS No.
- 1142090-23-0
- Chemical Name:
- GSK2256294A
- Synonyms
- GSK2256294A;GSK2256294A, 10 mM in DMSO;GSK 2256294A - GSK 2256294;GSK 2256294;GSK-2256294;GSK2256294;GSK-2256294A;GSK2256294A;(1R,3S)-N-(4-Cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide;Cyclohexanecarboxamide, N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]-, (1R,3S)-;GSK-2256294,GSK-2256294A,GSK2256294A,Inhibitor,Epoxide Hydrolase,GSK2256294,inhibit,cigarette smoke-exposure model,oral,COPD,cardiovascular,inflammation
- CBNumber:
- CB83067008
- Molecular Formula:
- C21H24F3N7O
- Molecular Weight:
- 447.46
- MDL Number:
- MFCD27987923
- MOL File:
- 1142090-23-0.mol
- MSDS File:
- SDS
Last updated:2025-04-17 18:22:24
| Product description | Number | Pack Size | Price |
| GSK2256294 | G797420 | 50mg | $1470 |
| GSK2256294A 99.51% | CS-5395 | 5mg | $264 |
| GSK2256294A 99.51% | CS-5395 | 10mg | $420 |
| GSK2256294A-GSK2256294 99% | Axon2220 | 5mg | $203.5 |
| GSK2256294A 99.51% | CS-5395 | 50mg | $1020 |
| Density | 1.34±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 47 mg/mL (105.04 mM) |
| form | Solid |
| pka | 14.75±0.40(Predicted) |
| color | White to off-white |
| InChIKey | LQHDJQIMETZMPH-ZBFHGGJFSA-N |
| SMILES | [C@@H]1(C(NCC2=CC=C(C#N)C=C2C(F)(F)F)=O)CCC[C@H](NC2=NC(C)=NC(NC)=N2)C1 |
| FDA UNII | L33EX3XR0T |
GSK2256294A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G797420 | GSK2256294 | 1142090-23-0 | 50mg | $1470 | 2021-12-16 | Buy |
| ChemScene | CS-5395 | GSK2256294A 99.51% | 1142090-23-0 | 5mg | $264 | 2021-12-16 | Buy |
| ChemScene | CS-5395 | GSK2256294A 99.51% | 1142090-23-0 | 10mg | $420 | 2021-12-16 | Buy |
| Axon Medchem | Axon2220 | GSK2256294A-GSK2256294 99% | 1142090-23-0 | 5mg | $203.5 | 2021-12-16 | Buy |
| ChemScene | CS-5395 | GSK2256294A 99.51% | 1142090-23-0 | 50mg | $1020 | 2021-12-16 | Buy |
GSK2256294A Chemical Properties,Uses,Production
Uses
GSK 2256294 is used in pharmacokinetics, pharmacodynamics and adverse event profile of novel soluble epoxide hydrolase inhibitor GSK2256294 in human against sEH enzyme activity.
in vivo
GSK2256294A (5-30 mg/kg; p.o. twice daily 5 days/week for two weeks) inhibits the generation and maintenance of pulmonary inflammation in cigarette smoke-exposed mice[1]. GSK2256294A (30 mg/kg; p.o. twice daily for 8 days) decreases pulmonary inflammation in cigarette smoke-exposed mice[1].
| Animal Model: | Mice exposed to cigarette smoke 5 days/week for 2 weeks[1] |
| Dosage: | 5 and 30 mg/kg |
| Administration: | Oral gavage; 5 and 30 mg/kg twice daily 5 days/week; for 2 weeks |
| Result: | Dose-dependently inhibited numbers of BAL fluid total cells, neutrophils, macrophages and the keratinocyte chemoattractant (KC) levels in lung tissue. |
| Animal Model: | Mice exposed to cigarette smoke 5 days/week for 2 weeks[1] |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage; 30 mg/kg twice daily; for 8 days |
| Result: | Significantly reduced neutrophils, macrophages and pulmonary inflammation in cigarette smoke-exposed mice. |
GSK2256294A Preparation Products And Raw materials
Raw materials
Preparation Products
GSK2256294A Suppliers
Global( 44)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 8011 | 55 |
GSK2256294A
GSK 2256294;GSK-2256294;GSK2256294;GSK-2256294A;GSK2256294A
GSK 2256294A - GSK 2256294
Cyclohexanecarboxamide, N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]-, (1R,3S)-
GSK-2256294,GSK-2256294A,GSK2256294A,Inhibitor,Epoxide Hydrolase,GSK2256294,inhibit,cigarette smoke-exposure model,oral,COPD,cardiovascular,inflammation
(1R,3S)-N-(4-Cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide
GSK2256294A, 10 mM in DMSO
1142090-23-0
C21H24F3N7O
