3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
- CAS No.
- 67416-61-9
- Chemical Name:
- 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
- Synonyms
- AKBA;Acetyl-11-keto-b-boswellic acid;Acetyl-11-keto-β-boswellic acid;3-acetyl-11-keto-β-Boswellic Acid;ACETYL-11-KETO-BETA-BOSWELLIC ACID;3-O-acetyl-11-keto-β-boswellic acid;3-O-Acetyl-11-keto-β-boswellic acid;AK-BETABA;AKBA, >98%;Boswellic Acid Impurity 3
- CBNumber:
- CB8309086
- Molecular Formula:
- C32H48O5
- Molecular Weight:
- 512.73
- MDL Number:
- MFCD03788777
- MOL File:
- 67416-61-9.mol
- MSDS File:
- SDS
| Melting point | 271℃ |
|---|---|
| Boiling point | 600.3±55.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| pka | 4.28±0.70(Predicted) |
| color | White to Off-White |
| LogP | 7.418 (est) |
| FDA UNII | BS16QT99Q1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HS Code | 2918300000 |
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9855 | 3-Acetyl-11-keto-β-boswellic acid | 67416-61-9 | 5mg | $417 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1076261 | 3-Acetyl-11-keto-β-boswellic acid United States Pharmacopeia (USP) Reference Standard | 67416-61-9 | 20mg | $741 | 2024-03-01 | Buy |
| Sigma-Aldrich | 74607 | 3-O-Acetyl-11-keto-β-boswellic acid analytical standard | 67416-61-9 | 5MG | $429 | 2022-05-15 | Buy |
| Cayman Chemical | 11672 | 3-acetyl-11-keto-β-Boswellic Acid ≥95% | 67416-61-9 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 11672 | 3-acetyl-11-keto-β-Boswellic Acid ≥95% | 67416-61-9 | 5mg | $161 | 2024-03-01 | Buy |
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Chemical Properties,Uses,Production
Description
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner. 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
Uses
3-Acetyl-11-keto-β-boswellic Acid (AKBA), be used in the place of the non-steroidal anti-inflammatory drug. AKBA, also inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway. It can be used as an anticancer agent.
Definition
ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid.
in vitro
akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1].
in vivo
pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].
IC 50
1.5 μm
References
[1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180.
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 268 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Acetyl-11-Keto-β -Boswellic Acid
67416-61-9
|
US $0.00 / kg | 1kg | 99% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2023-02-24 | Acetyl-11-keto-β-boswellic acid
67416-61-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-01-14 | 3-Acetyl-11-keto-beta-boswellic acid
67416-61-9
|
US $788.00 / g | 1g | 98.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Acetyl-11-Keto-β -Boswellic Acid
67416-61-9
- US $0.00 / kg
- 99%
- BINBO BIOLOGICAL CO.,LTD
-
- Acetyl-11-keto-β-boswellic acid
67416-61-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- 3-Acetyl-11-keto-beta-boswellic acid
67416-61-9
- US $788.00 / g
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
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