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Calcium acetate

Chemical properties Uses Toxicity Usage limit Production method Hazards & Safety Information
Calcium acetate
Calcium acetate structure
CAS No.
62-54-4
Chemical Name:
Calcium acetate
Synonyms
teltozan;FEMA 2228;grayacetate;limeacetate;vinegarsalts;brownacetate;MAGGRAN(R) CA;sorbo-calcion;Calciumacetat;MAGNESIA 87219
CBNumber:
CB8312095
Molecular Formula:
C4H6CaO4
Formula Weight:
158.17
MOL File:
62-54-4.mol

Calcium acetate Properties

Melting point:
160°C (dec.)
Density 
1,5 g/cm3
refractive index 
1.5500
FEMA 
2228 | CALCIUM ACETATE
Flash point:
160°C
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Powder
Specific Gravity
1.50
color 
white
Water Solubility 
soluble
Decomposition 
160 ºC
Stability:
Stable. Non-flammable. Incompatible with strong oxidizing agents.
InChIKey
VSGNNIFQASZAOI-UHFFFAOYSA-L
FDA 21 CFR
182.6197; 184.1185; 582.6185; 582.6197; 175.300; 181.29
Substances Added to Food (formerly EAFUS)
CALCIUM ACETATE
SCOGS (Select Committee on GRAS Substances)
Calcium acetate
CAS DataBase Reference
62-54-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
Y882YXF34X
EPA Substance Registry System
Calcium acetate (62-54-4)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  AF7525000
TSCA  Yes
HS Code  29152990
NFPA 704
0
1 1

Calcium acetate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1362 Calcium Acetate Pharmaceutical Secondary Standard; Certified Reference Material 62-54-4 5g $35.6 2021-03-22 Buy
Sigma-Aldrich 1086334 Calcium Acetate United States Pharmacopeia (USP) Reference Standard 62-54-4 1g $348 2018-11-13 Buy
Strem Chemicals 93-2001 Calcium acetate monohydrate, 98% 62-54-4 250g $52 2021-03-22 Buy
Strem Chemicals 93-2001 Calcium acetate monohydrate, 98% 62-54-4 1kg $155 2021-03-22 Buy
Sigma-Aldrich 1086334 Calcium acetate United States Pharmacopeia (USP) Reference Standard 62-54-4 500mg $366 2021-03-22 Buy

Calcium acetate Chemical Properties,Uses,Production

Chemical properties

Calcium acetate, also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It is an odorless powder. Calcium has an important role in the nutrition of humans and animals. Hormonal mechanisms control absorption of dietary calcium (including added calcium salts) allowing adaptation to a range of calcium intakes while maintaining a relatively constant blood calcium concentration of about 10 mg/100 mL. Major functions of calcium inside the body include the formation and maintenance of bones and teeth, the physiology of muscle contraction, the cell membrane integrity, the activity of several enzymes that have specific requirement for it, the coagulation of blood, and the regulation of acid-base balance.*

Uses

Calcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry. It is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life.

Toxicity

ADI is not subject to restrictive regulations (FAO/WHO, 2001).
GRAS (FDA, §181.29, §182.6197, § 184.1185, 2000).
LD50: 52 mg/kg (mouse, subcutaneous).

Usage limit

GB 14880 a 94: cereals and their products, beverages 8~16g/kg.
GB 2760-2001: vinegar, 6~8g/kg (in terms of Ca).
FAO/WHO (1984): Edible caseinate, GMP.
FDA, § 184.1185 (2000): baked goods, gelatin, pudding, fillings, 0.2%; sweet sauce, top materials and poured, 0.15%;
EEC can be used for packaging cheese powder, quick-setting jelly powder.
FEMA (mg/kg): soft drinks 200; baked goods 500.

Production method

It is obtained by the reaction between calcium carbonate and acetic acid. Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid. After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate.
It is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization.
It is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate. Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt.
Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk. And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%.
To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated  80 ° C for reaction of 2-3h. The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products.

Hazards & Safety Information

Category:  Toxic substances
Toxicity classification:  highly toxic
Acute toxicity:  intravenous-mouse LD50: 52 mg/kg; celiac-mouse LD50: 75 mg/kg
Flammability and Hazardous characteristics:  Thermal decomposition releases Pungent irritation Smoke
Storage and transportation characteristics:Treasury: ventilated, low temperature drying; store it separately from food raw materials
Fire extinguishing agent:  water, dry powder, foam, carbon dioxide

Description

Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C2H3O2)2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2?H2O) is the common form.

Chemical Properties

Calcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder.

Uses

Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.

Uses

Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant.

Definition

ChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.

Production Methods

Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO3 + 2CH3COOH → Ca(CH3COO)2 + H2O + CO2
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.

Preparation

Produced by calcium hydroxide neutralization of acetic acid.

Pharmaceutical Applications

Calcium acetate is used as a preservative in oral and topical formulations.
Therapeutically, parenteral calcium acetate acts as a source of calcium ions for hypocalcemia or electrolyte balance. Oral calcium acetate is used as a complexing agent for hyperphosphatemia in dialysis patients. Calcium acetate is also used in the food industry as a stabilizer, buffer and sequestrant.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mutation data reported. See also CALCIUM COMPOUNDS. When heated to decomposition it emits acrid smoke and fumes.

Safety

Calcium acetate is used in oral and topical formulations. The pure form of calcium acetate is toxic by IP and IV routes.
LD50 (mouse, IP): 0.075 g/kg
LD50 (mouse, IV): 0.052 g/kg
LD50 (rat, oral): 4.28 g/kg

Veterinary Drugs and Treatments

Calcium acetate can be used for oral administration to treat hyperphosphatemia in patients with chronic renal failure. Secondary to its phosphorus binding efficiency and lower concentration of elemental calcium, calcium acetate is considered the most effective and having the lowest potential for causing hypercalcemia of the calcium-based phosphorus-binding agents. When compared to calcium carbonate, calcium acetate binds approximately twice as much phosphorus per gram of elemental calcium administered. Unlike calcium citrate, calcium acetate does not promote aluminum absorption.

storage

Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. It decomposes on heating (above 1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.

Purification Methods

Recrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.]

Incompatibilities

Calcium acetate is incompatible with strong oxidizing agents and moisture.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral suspensions and tablets; topical emulsions, lotions, and creams). Included in nonparenteral medicines (oral tablets) licensed in the UK.

Calcium acetate Preparation Products And Raw materials

Raw materials

Preparation Products


Calcium acetate Suppliers

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View Lastest Price from Calcium acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-14 calcium acetate
62-54-4
US $1.50 / Kg/Bag 25KG 98% 200 tons Hebei Dongdu Import and Export Co. LTD
2021-09-07 Calcium acetate
62-54-4
US $12.00 / Kg/Drum 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
2021-08-26 Calcium acetate
62-54-4
US $10.50 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd

Calcium acetate Spectrum


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