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Calcium acetate

Chemical properties Uses Identification test Solubility in water (g / 100ml) Content analysis Toxicity Usage limit Production method Hazards & Safety Information
Calcium acetate
Calcium acetate structure
Chemical Name:
Calcium acetate
teltozan;FEMA 2228;limeacetate;grayacetate;brownacetate;vinegarsalts;sorbo-calcion;Calciumacetat;MAGGRAN(R) CA;MAGNESIA 87219
Molecular Formula:
Formula Weight:
MOL File:

Calcium acetate Properties

Melting point:
160°C (dec.)
1,5 g/cm3
refractive index 
Flash point:
H2O: 1 M at 20 °C, clear, colorless
Water Solubility 
160 ºC
Stable. Non-flammable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
62-54-4(CAS DataBase Reference)
EPA Substance Registry System
Acetic acid, calcium salt(62-54-4)


Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  AF7525000
HS Code  29152990
Hazardous Substances Data 62-54-4(Hazardous Substances Data)

Calcium acetate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1362 Calcium Acetate Pharmaceutical Secondary Standard; Certified Reference Material 62-54-4 5g $30.4 2018-11-13 Buy
Sigma-Aldrich 1086334 Calcium Acetate United States Pharmacopeia (USP) Reference Standard 62-54-4 1g $348 2018-11-13 Buy
Strem Chemicals 93-2001 Calcium acetate monohydrate, 98% 62-54-4 250g $48 2018-11-13 Buy
Strem Chemicals 93-2001 Calcium acetate monohydrate, 98% 62-54-4 1kg $143 2018-11-13 Buy
Sigma-Aldrich 1086334 Calcium acetate United States Pharmacopeia (USP) Reference Standard 62-54-4 500mg $352.8 2018-11-23 Buy

Calcium acetate Chemical Properties,Uses,Production

Chemical properties

This reagent appears as white needle crystal, being soluble in water and inorganic acid, slightly soluble in ethanol.


1.  Calcium acetate is used in the industry for the manufacturing of acetone, acetic acid and polyester.
2.  It can be used as food stabilizers, corrosion inhibitors as well as for the synthesis of acetate
3.  It is used as analysis reagents as well as the synthesis of acetate.
4.  Calcium acetate is a excellent food calcium fortifier with better absorption effect than inorganic calcium. It can be used for infant food with the usage amount of 3.0~6.0g/kg (in terms of elemental calcium, the same as below); in cereals and their products, the usage amount is 1.6~3.2g/kg; in drinks and milk drinks, it is 0.6~0.8 G/kg.
5.  Chelating agents; mold inhibitors; stabilizers; buffers; flavoring agents; preservatives; curing agents; nutritional fortifiers;
6.  For the analysis of reagents, organic synthesis, printing and dyeing and pharmaceutical industry, or as a food stabilizer, chelating agent, mold inhibitor, buffer, flavoring agent, corrosion inhibitor.

Identification test

Solubility: easily soluble in water; insoluble in ethanol. Determine it according to OT-42 method.
Identification of acetate salt
Use a piece of filter paper (slightly large than the mouth of the test tube) to cover the mouth of the hard glass test tube containing the sample. The filter paper was wetted with a freshly prepared basic o-nitrobenzaldehyde test solution (TS-161). The test tube is hung up through the asbestos board, further subjecting to slow heating with a gas flame. Filter paper will turn from blue to blue-green, indicating the presence of acetate.
Supply 1: 1 sulfuric acid to the sample after heating. Acetic acid can be discerned by odor.
Identification of calcium: add ammonium oxalate solution (TS-24) to the sample solution for forming white precipitate, soluble in hydrochloric acid, but insoluble in acetic acid.

Solubility in water (g / 100ml)

Dissolved grams per 100 ml of water at different temperatures (° C):
37.4 g/0 ° C; 36 g/10 ° C; 34.7 g/20 ° C; 33.8 g/30 ° C; 33.2 g /
32.7 g/60 ° C; 33.5 g/80 ° C; 31.1 g/90 ° C; 29.7 g/100 ° C

Content analysis

Determination of calcium: accurately weigh 2.5 g in the beaker (accurate to l mg), dissolve in 5 ml of hot dilute hydrochloric acid test solution (TS-117). After cooling, transfer it to a 250ml volumetric flask and mix with water. 50 ml of this solution was transferred to a 400 ml beaker; successively add 100 ml water, 25 ml sodium hydroxide solution (TS-224), 40 mg ammonium purpurinate indicator and 3 ml naphthol green test solution (TS-154). Apply 0.05mol/L EDTA disodium for titration to dark blue color. Each mL of 0.05mol/L EDTA disodium is equivalent to 7.909 mg of calcium acetate (C4H6CaO4).
Method for determination of acid content; apply strong acid type cation exchange resin (Amberlite IRl20, 100; Duolit c III; Dorvex 50; Lewatit KS; Ion Exchanger I Merck) to fill with half of a column (1.5 cm in diameter, 20 cm in length). Close the discharge orifice of the column. Add 0.1mol/L hydrochloric acid from the top to until the resin was completely submerged, placed for 1~2h. The acid was drained, and the column was rinsed with water (about 1000 ml) until when 20 ml elute exhibits red color after being added of one drop of 0.02 mol/L sodium hydroxide and phenolphthalein test solution (TS-167). Weigh 0.05 g sample pre-dried at 155 ℃to constant weight (accurate to 1mg), place in the flask, add 15 ml water for dissolving and slowly add into the column. The flask and column were washed with about 200 ml of water, and the effluent was collected in an Erlenmeyer flask. Add 2 drops of phenolphthalein test solution (TS-167). Apply 0.1mol/L sodium hydroxide through the micro-titration for titration. Each mL of 0.1 mol/L sodium hydroxide corresponds to 7.909 mg of calcium acetate (C.H6CaO4).


ADI is not subject to restrictive regulations (FAO/WHO, 2001).
GRAS (FDA, §181.29, §182.6197, § 184.1185, 2000).
LD50: 52 mg/kg (mouse, subcutaneous).

Usage limit

GB 14880 a 94: cereals and their products, beverages 8~16g/kg.
GB 2760-2001: vinegar, 6~8g/kg (in terms of Ca).
FAO/WHO (1984): Edible caseinate, GMP.
FDA, § 184.1185 (2000): baked goods, gelatin, pudding, fillings, 0.2%; sweet sauce, top materials and poured, 0.15%;
EEC can be used for packaging cheese powder, quick-setting jelly powder.
FEMA (mg/kg): soft drinks 200; baked goods 500.

Production method

It is obtained by the reaction between calcium carbonate and acetic acid. Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid. After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate.
It is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization.
It is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate. Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt.
Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk. And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%.
To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated  80 ° C for reaction of 2-3h. The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products.

Hazards & Safety Information

Category:  Toxic substances
Toxicity classification:  highly toxic
Acute toxicity:  intravenous-mouse LD50: 52 mg/kg; celiac-mouse LD50: 75 mg/kg
Flammability and Hazardous characteristics:  Thermal decomposition releases Pungent irritation Smoke
Storage and transportation characteristics:Treasury: ventilated, low temperature drying; store it separately from food raw materials
Fire extinguishing agent:  water, dry powder, foam, carbon dioxide


Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C2H3O2)2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2?H2O) is the common form.

Chemical Properties

Calcium acetate, also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It is an odorless powder. Calcium has an important role in the nutrition of humans and animals. Hormonal mechanisms control absorption of dietary calcium (including added calcium salts) allowing adaptation to a range of calcium intakes while maintaining a relatively constant blood calcium concentration of about 10 mg/100 mL. Major functions of calcium inside the body include the formation and maintenance of bones and teeth, the physiology of muscle contraction, the cell membrane integrity, the activity of several enzymes that have specific requirement for it, the coagulation of blood, and the regulation of acid-base balance.*

Chemical Properties

white crystals or powder

Chemical Properties

Calcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder.


Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.


Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant.


Pharmaceutic aid (buffering agent).


ChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.


Produced by calcium hydroxide neutralization of acetic acid.

Production Methods

Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO3 + 2CH3COOH → Ca(CH3COO)2 + H2O + CO2
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.

Production Methods

Calcium acetate is manufactured by the reaction of calcium carbonate or calcium hydroxide with acetic acid or pyroligneous acid.

Pharmaceutical Applications

Calcium acetate is used as a preservative in oral and topical formulations.
Therapeutically, parenteral calcium acetate acts as a source of calcium ions for hypocalcemia or electrolyte balance. Oral calcium acetate is used as a complexing agent for hyperphosphatemia in dialysis patients. Calcium acetate is also used in the food industry as a stabilizer, buffer and sequestrant.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mutation data reported. See also CALCIUM COMPOUNDS. When heated to decomposition it emits acrid smoke and fumes.


Calcium acetate is used in oral and topical formulations. The pure form of calcium acetate is toxic by IP and IV routes.
LD50 (mouse, IP): 0.075 g/kg
LD50 (mouse, IV): 0.052 g/kg
LD50 (rat, oral): 4.28 g/kg

Veterinary Drugs and Treatments

Calcium acetate can be used for oral administration to treat hyperphosphatemia in patients with chronic renal failure. Secondary to its phosphorus binding efficiency and lower concentration of elemental calcium, calcium acetate is considered the most effective and having the lowest potential for causing hypercalcemia of the calcium-based phosphorus-binding agents. When compared to calcium carbonate, calcium acetate binds approximately twice as much phosphorus per gram of elemental calcium administered. Unlike calcium citrate, calcium acetate does not promote aluminum absorption.


Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. It decomposes on heating (above 1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.

Purification Methods

Recrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.]


Calcium acetate is incompatible with strong oxidizing agents and moisture.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral suspensions and tablets; topical emulsions, lotions, and creams). Included in nonparenteral medicines (oral tablets) licensed in the UK.

Calcium acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Calcium acetate Suppliers

Global( 217)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Kolod Food Ingredients Co.,Ltd.
+86-518-85110578 18805133257
+86-518-85110578 CHINA 100 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21956 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32452 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1787 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
career henan chemical co
+86-371-86658258 CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23959 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20084 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 8266 58

View Lastest Price from Calcium acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 Calcium acetate
US $1.00 / KG 1KG 99% 25kg career henan chemical co
2019-01-29 Calcium Acetate
US $0.00 / kg 25kg 99% 200 tons Jiangsu Kolod Food Ingredients Co.,Ltd.
2018-04-10 calcium acetate
US $10.00 / KG 25KG 98%--102% 2000 tons Jiangsu Kolod Food Ingredients Co.,Ltd.

Calcium acetate Spectrum

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