Amfonelic acid
- CAS No.
- 15180-02-6
- Chemical Name:
- Amfonelic acid
- Synonyms
- NCA;Amfonelic;WIN-25978;NSC-100638;Amphonic acid;AMFONELIC ACID;Diphenyl sulfide 139-66-2;AMFONELIC ACID INCREASES DOPAMINE RE;Amfonelic Acid/ CAS NO.15180-02-6/99%;7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylicaci
- CBNumber:
- CB8315692
- Molecular Formula:
- C18H16N2O3
- Molecular Weight:
- 308.33
- MDL Number:
- MFCD00055095
- MOL File:
- 15180-02-6.mol
- MSDS File:
- SDS
| Melting point | >1000 °C |
|---|---|
| Boiling point | 499℃ |
| Density | 1.297 |
| Flash point | 256℃ |
| solubility | 0.1 M NaOH: soluble |
| form | powder |
| pka | 3.50±0.20(Predicted) |
| color | yellow |
| InChI | InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23) |
| InChIKey | WHHHJDGNBVQNAU-UHFFFAOYSA-N |
| SMILES | N1(CC)C2C(=CC=C(CC3=CC=CC=C3)N=2)C(=O)C(C(O)=O)=C1 |
| FDA UNII | RR302AR19Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 40-43 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| NFPA 704 |
|
Amfonelic acid price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A3356 | Amfonelic Acid | 15180-02-6 | 10MG | $475 | 2024-03-01 | Buy |
| Chem-Impex | 38450 | Amfonelicacid,≥97%(HPLC) ≥97%(HPLC) | 15180-02-6 | 10MG | $546.29 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0000377 | AMFONELIC ACID 95.00% | 15180-02-6 | 250MG | $1067.22 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0000377 | AMFONELIC ACID 95.00% | 15180-02-6 | 1G | $1428 | 2021-12-16 | Buy |
| AK Scientific | SYN5501 | Amfonelic Acid | 15180-02-6 | 100mg | $2268 | 2021-12-16 | Buy |
Amfonelic acid Chemical Properties,Uses,Production
Description
Amfonelic acid, a derivative of nalidixic acid, was originally developed as a central nervous system stimulant. It is a highly potent nonamphetamine stimulant whose actions are inhibited by reserpine but not by the tyrosine hydroxylase inhibitor, a-methyltyrosine. Additionally, it enhances the impacts of antipsychotic medicines such as haloperidol, trifluoperazine, and spiperone.
Uses
Amfonelic acid (AFA) is a dopamine reuptake inhibitor, that has marked effects on brain dopamine metabolism but not noradrenaline metabolism. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically. Rats are shown to self-administer amfonelic acid in a dose-dependent manner.
Biological Activity
Amfonelic acid (AFA), an inhibitor of dopamine (DA) uptake, has been found to increase the levels of tryptophan (TRYP) and 5-hydroxyindoleacetic acid (5-HIAA) in the rat c. striatum, cerebral cortex, and brain stem. The duration of action of the effect of AFA on TRYP and 5-HIAA appeared to be longer than that of the increase of the striatal DA metabolites homovanillic acid and 3,4-dihydroxyphenylacetic acid[1].
References
The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward DOI: 10.1016/0091-3057(89)90069-5
Pharmacologic properties and mechanism of action of amfonelic acid DOI: 10.1016/0014-2999(70)90206-2
References
[1] P C Waldmeier. “The effects of amfonelic acid on 5-HT metabolism in rat brain.” Journal of Neural Transmission 57 3 (1983): 149–65.
Amfonelic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| LY Global chemicals co.,ltd . | +8618939937369 | info@lychems.cn | China | 969 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
View Lastest Price from Amfonelic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-25 | Amfonelic acid
15180-02-6
|
US $33.00-1.40 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-12-04 | Amfonelic acid
15180-02-6
|
US $0.00-0.00 / kg | 0.1kg | 97% HPLC | 100 KG | LY Global chemicals co.,ltd . | |
 |
2023-11-13 | Amfonelic acid
15180-02-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Amfonelic acid
15180-02-6
- US $33.00-1.40 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Amfonelic acid
15180-02-6
- US $0.00-0.00 / kg
- 97% HPLC
- LY Global chemicals co.,ltd .
-
- Amfonelic acid
15180-02-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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