ChemicalBook >> CAS DataBase List >>Glecaprevir
Glecaprevir
- CAS No.
- 1365970-03-1
- Chemical Name:
- Glecaprevir
- Synonyms
- ABT-493;CS-2616;Glecaprevir;Glecaprevir INN;Glecaprevir API;Glecaprevir 13CD3;ABT-493(Glecaprevir);Glecaprevir(ABT-493);ABT-493;ABT 493;ABT493;GLECAPREVIR;(1R,2R)-N-[[[(1R,2R)-2-[[4,4-Difluoro-4-(3-hydroxy-2-quinoxalinyl)-2-buten-1-yl]oxy]cyclopentyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-2-(difluoromethyl)-N-[(1-methylcyclopropyl)sulfonyl]cyclopropanecarboxamide cyclic (1→2)-ether
- CBNumber:
- CB83159912
- Molecular Formula:
- C38H46F4N6O9S
- Molecular Weight:
- 838.87
- MDL Number:
- MFCD30533436
- MOL File:
- 1365970-03-1.mol
Last updated:2023-09-20 16:43:00
| Melting point | >186°C (dec.) |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.46±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | K6BUU8J72P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Glecaprevir price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27934 | Glecaprevir | 1365970-03-1 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 27934 | Glecaprevir | 1365970-03-1 | 25mg | $745 | 2024-03-01 | Buy |
| Cayman Chemical | 27934 | Glecaprevir | 1365970-03-1 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 27934 | Glecaprevir | 1365970-03-1 | 10mg | $341 | 2024-03-01 | Buy |
| ChemScene | CS-8098 | Glecaprevir 99.93% | 1365970-03-1 | 5mg | $420 | 2021-12-16 | Buy |
Glecaprevir Chemical Properties,Uses,Production
Approval
On 19 December 2016, AbbVie submitted a new drug application to the U.S. Food and Drug Administration for the glecaprevir/pibrentasvir (trade name Mavyret) regimen for the treatment of all major genotypes of chronic hepatitis C. On 3 August 2017 the FDA approved the combination for hepatitis C treatment. In Europe, it was approved on 17 August 2017 for the same indication, under the trade name Maviret.
Uses
Glecaprevir is an antiviral drug used in the treatment of patients with hepatitis C virus (HCV) genotype 1-6, of special interest for the treatment of patients with chronic kidney disease also suffering from HCV.
Uses
Glecaprevir (INN) is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that was identified jointly by AbbVie and Enanta Pharmaceuticals. It is being developed as a treatment of chronic hepatitis C infection in co-formulation with an HCV NS5A inhibitor pibrentasvir. Together they demonstrated potent antiviral activity against major HCV genotypes and high barriers to resistance in vitro.
Side effects
The most common adverse effects, observed in at least 10% of phase 3 trial participants, were headache and fatigue.
Glecaprevir Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 93)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Huaian yishu technology co.,ltd | 86-0517-85883738 13852390259 | sales@yishuchem.com | CHINA | 53 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
Related articles
- Glecaprevir-Pibrentasvir (Mavyret)
- MAVYRET is a prescription medicine used to treat adults and children 12 years of age and older or weighing at least 99 pounds ....
- Dec 21，2021
View Lastest Price from Glecaprevir manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | Glecaprevir
1365970-03-1
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- Glecaprevir
1365970-03-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
1365970-03-1(Glecaprevir)Related Search:
(33R,35S,91R,92R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxylic acid
(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride
3-(1,1-difluoroallyl)quinoxalin-2-ol
methyl (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxylate
2-chloro-3-(1,1-difluoroallyl)quinoxaline
1of2
Glecaprevir
(33R,35S,91R,92R,5S,E)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35
Glecaprevir API
(1R,2R)-N-[[[(1R,2R)-2-[[4,4-Difluoro-4-(3-hydroxy-2-quinoxalinyl)-2-buten-1-yl]oxy]cyclopentyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-2-(difluoromethyl)-N-[(1-methylcyclopropyl)sulfonyl]cyclopropanecarboxamide cyclic (1→2)-ether
ABT-493(Glecaprevir)
CS-2616
ABT-493;ABT 493;ABT493;GLECAPREVIR
Glecaprevir(ABT-493)
Cyclopropanecarboxamide, N-[[[(1R,2R)-2-[[4,4-difluoro-4-(3-hydroxy-2-quinoxalinyl)-2-buten-1-yl]oxy]cyclopentyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-2-(difluoromethyl)-N-[(1-methylcyclopropyl)sulfonyl]-, cyclic (1→2)-ether, (1R,2R)-
Glecaprevir INN
Glecaprevir 13CD3
ABT-493
(33R,35S,91R,92R,5S,E)-5-(tert-Butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxamide
1365970-03-1
1367970-03-1
C38H46F4N6O9S