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4-Iodophenol

4-Iodophenol structure

CAS No.: 540-38-5

Chemical Name:: 4-Iodophenol

Synonyms: P-IODOPHENOL;p-Jodphenol;p-iodo-pheno;4-IODOPHENOL;4-iodo-pheno;4-lodophenoI;Phenol, p-iodo-;PHENOL, 4-IODO-;4-Iodophenol99%;PARA-IODOPHENOL

CBNumber:: CB8328252

Molecular Formula:: C6H5IO

Molecular Weight:: 220.01

MDL Number:: MFCD00002327

MOL File:: 540-38-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-10 10:27:30

Product description	Number	Pack Size	Price
4-Iodophenol 99%	I10201	10g	$72
4-Iodophenol 99%	I10201	25g	$113
4-Iodophenol >98.0%(GC)	I0311	10g	$50
4-Iodophenol >98.0%(GC)	I0311	25g	$95
4-Iodophenol [for Biochemical Research] >98.0%(GC)	I0840	1g	$25
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4-Iodophenol Properties

Melting point	92-94 °C(lit.)
Boiling point	138 °C5 mm Hg(lit.)
Density	1.8573
Flash point	138°C/5mm
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Crystals or Crystalline Powder
pka	9.33(at 25℃)
color	Pink or beige to brown
Water Solubility	slightly soluble
Sensitive	Light Sensitive
Merck	14,5036
BRN	1904544
Henry's Law Constant	4.6×10¹ mol/(m³Pa) at 25℃, Hilal et al. (2008)
Stability	Stable. Incompatible with strong oxidizing agents.
InChI	1S/C6H5IO/c7-5-1-3-6(8)4-2-5/h1-4,8H
InChIKey	VSMDINRNYYEDRN-UHFFFAOYSA-N
SMILES	Oc1ccc(I)cc1
CAS DataBase Reference	540-38-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	BH194BAK0B
NIST Chemistry Reference	Phenol, 4-iodo-(540-38-5)
EPA Substance Registry System	p-Iodophenol (540-38-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302+H312-H314

Precautionary statements

P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,Xi,Xn

Risk Statements

21/22-34-36/37/38-20/21/22

Safety Statements

26-36/37/39-45-22

RIDADR

UN 3261 8/PG 3

WGK Germany

RTECS

SL5600000

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

IRRITANT, LACHRYMATOR

HS Code

29081900

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Skin Corr. 1B

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		1

4-Iodophenol price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I10201	4-Iodophenol 99%	540-38-5	10g	$72	2026-03-19	Buy
Sigma-Aldrich	I10201	4-Iodophenol 99%	540-38-5	25g	$113	2026-03-19	Buy
TCI Chemical	I0311	4-Iodophenol >98.0%(GC)	540-38-5	10g	$50	2026-03-19	Buy
TCI Chemical	I0311	4-Iodophenol >98.0%(GC)	540-38-5	25g	$95	2026-03-19	Buy
TCI Chemical	I0840	4-Iodophenol [for Biochemical Research] >98.0%(GC)	540-38-5	1g	$25	2026-03-19	Buy

Product number	Packaging	Price	Buy
I10201	10g	$72	Buy
I10201	25g	$113	Buy
I0311	10g	$50	Buy
I0311	25g	$95	Buy
I0840	1g	$25	Buy

4-Iodophenol Chemical Properties,Uses,Production

Chemical Properties

Light brown powder. It dissolves slightly in water, but readily dissolves in ethanol, ether, and other organic solvents.

Uses

4-Iodophenol is used in chemiluminescence imaging assays and experiments, as diagnostic agents in order to detect cancer cells in patients. It is also utilized in synthesizing agonists for the estrogen β receptor. Additionally, The compound finds extensive applications in various medical industries as well as in human and animal nutrition products such as pharmaceutical intermediates, and polarizing films for Liquid Crystal Display (LCD) chemicals.

Preparation

It is obtained from 4-Aminophenol by diazotisation and substitution.

Application

4-Iodophenol can be used as a building block for the synthesis of:
Hydroxybiaryls by reacting with aryl boronic acids via Pd-catalyzed Suzuki-Miyaura coupling reaction.[1][2]
Aryl substituted olefins by reacting with acrylates via Pd-catalyzed Heck reaction.[3]
Iodinated-4-aryloxymethylcoumarins [4]
Hydroxylated stilbenoids [5] and psammaplysenes A and B.[6]

Definition

ChEBI: 4-iodophenol is an iodophenol.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 355, 1943
The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x
Tetrahedron Letters, 40, p. 6051, 1999 DOI: 10.1016/S0040-4039(99)01236-8

Metabolism

4-Iodophenol has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-(4-iodophenoxy)oxane-2-carboxylic acid.

Purification Methods

Crystallise 4-iodophenol from pet ether (b 80-100o) or distil it in vacuo. If the material has a brown or violet color, then dissolve it in CHCl3, shake it with 5% sodium thiosulfate solution until is colourless. Dry (Na2SO4), extract, evaporate and disil the residue in vacuo. [Dains & Eberly Org Synth Coll Vol II 355 1948, Beilstein 6 IV 1074.]

References

[1] HIDEHIRO SAKURAI Toshikazu H Tatsuya Tsukuda. Pd/C as a Reusable Catalyst for the Coupling Reaction of Halophenols and Arylboronic Acids in Aqueous Media[J]. The Journal of Organic Chemistry, 2002, 67 8: 2721-2722. DOI:10.1021/jo016342k.
[2] PIOTR WAWRZYNIAK Joachim H. Microwave-Promoted Suzuki—Miyaura Coupling of Arylboronic Acids with 1-Bromo-2-naphthol, o-Bromophenol, and o-Chlorophenol.[J]. ChemInform, 2007, 38 14. DOI:10.1002/chin.200714105.
[3] LUNXIANG YIN Juergen L. Carbon—Carbon Coupling Reactions Catalyzed by Heterogeneous Palladium Catalysts[J]. ChemInform, 2007, 38 22. DOI:10.1002/chin.200722237.
[4] MAHANTESHA BASANAGOUDA . Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents[J]. European Journal of Medicinal Chemistry, 2014, 74: Pages 225-233. DOI:10.1016/j.ejmech.2013.12.061.
[5] AMIT SHARD. Tandem Heck/Decarboxylation/Heck Strategy: Protecting-Group-Free Synthesis of Symmetric and Unsymmetric Hydroxylated Stilbenoids[J]. Angewandte Chemie International Edition, 2012, 51 49: 12250-12253. DOI:10.1002/anie.201206346.
[6] SAVVAS N. GEORGIADES Jon C. Total Synthesis of Psammaplysenes A and B, Naturally Occurring Inhibitors of FOXO1a Nuclear Export[J]. Organic Letters, 2005, 7 19: 4091-4094. DOI:10.1021/ol0513286.

4-Iodophenol synthesis

Synthesis of 4-Iodophenol from 4-Iodophenylboronic acid

4-Iodophenol Preparation Products And Raw materials

Raw materials

Copper 4-Aminophenol

Preparation Products

4-Iodophenoxyacetic acid 4-Hydroxyphenylboronic acid pinacol ester 4-Mercaptophenol 2-(4-IODOPHENOXY)BENZENECARBALDEHYDE 4-Cyanophenol

5-Iodobenzofuran 4-ALLYLPHENOL 4-IODO-3-NITROPHENOL 2-HYDROXY-5-IODO-BENZALDEHYDE 4,4′-dihydroxydiphenyl disulfide

1-Eth-1-ynyl-4-(pentyloxy)benzene 4-Hydroxy-4'-fluorobiphenyl Benzene, 1-iodo-4-(2-propyn-1-yloxy)-

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4-Iodophenol Suppliers

Global( 406)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenyang TYSChem Co., Ltd.	+86-24-83607930 +8618640359690	sales@honghuchem.com	China	403	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Shenyang TYSChem Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
HaBo Hong Kong Co., Limited.	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 4-Iodophenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	4-Iodophenol 540-38-5	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-06-20	4-Iodophenol 540-38-5	US $0.00 / kg	1kg	99.00%	20tons	Hebei Yanxi Chemical Co., Ltd.
2021-07-13	4-Iodophenol 540-38-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

4-Iodophenol
540-38-5
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Iodophenol
540-38-5
US $0.00 / kg
99.00%
Hebei Yanxi Chemical Co., Ltd.

4-Iodophenol
540-38-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-Iodophenol Spectrum

4-Iodophenol(540-38-5)¹HNMR 4-Iodophenol(540-38-5)Raman 4-Iodophenol(540-38-5)FT-IR

540-38-5(4-Iodophenol)Related Search:

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5,7-Diiodo-8-quinolinol 5-IODO-O-VANILLIN ERYTHROSIN B

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