ChemicalBook
Chinese Japanese Germany Korea

Polydatin

Polydatin
Polydatin structure
CAS No.
65914-17-2
Chemical Name:
Polydatin
Synonyms
PICEID;Polydatin;Polydatin;Polydatine;Polydatain;Polydatin 98%;Polydatin ,98%;Polydatin(Piceid);RESVERATROL GLUCOSIDE;RESVERATROL-3-B-D-GLUCOSIDE
CBNumber:
CB8328919
Molecular Formula:
C20H23O9
Formula Weight:
407.39
MOL File:
65914-17-2.mol

Polydatin Properties

Melting point:
223-226 °C(lit.)
alpha 
-55 º (c=1,acetone)
form 
White to off-white solid.
color 
White to off-white solid.
optical activity
[α]20/D 55°, c = 1 in acetone
BRN 
54837
CAS DataBase Reference
65914-17-2(CAS DataBase Reference)

SAFETY

Safety Statements  22-24/25
WGK Germany  3
HS Code  29389090

Polydatin price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 15721 Polydatin ≥95% (HPLC) 65914-17-2 25g $228 2018-11-13 Buy
Sigma-Aldrich 1546194 Polydatin United States Pharmacopeia (USP) Reference Standard 65914-17-2 20mg $303 2018-11-20 Buy
Cayman Chemical 21246 Polydatin ≥98% 65914-17-2 1g $35 2018-11-19 Buy
Cayman Chemical 21246 Polydatin ≥98% 65914-17-2 5g $96 2018-11-19 Buy
Sigma-Aldrich 572691 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside 97% 65914-17-2 1g $235 2018-11-13 Buy

Polydatin Chemical Properties,Uses,Production

Description

Polydatin (PD) is a major chemical component of Polygonum cuspidatum and it could also be found in a variety of other sources. PD is a polyphenol belonging to the chemical family of stilbenoids. Previous studies have shown that PD exhibits many pharmacological activities, including cardioprotective, neuroprotective, and antioxidative activities. With vascular dementia (VaD) rat models, PD markedly attenuated cognitive deficits. Biochemical analysis revealed that PD decreased the production of malondialdehyde (MDA) and significantly increased superoxide dismutase and catalase activities. Additionally, PD effectively alleviated the injuries of cultured neurons induced by oxygen–glucose deprivation. The therapeutic potential of PD for VaD seems related to its antioxidative activity and the direct protection of neurons. Furthermore, PD could also effectively inhibit the polymerization of amyloid-β peptides, which is a major mark in the progression of pathogenesis in Alzheimer’s disease (AD). These results suggest that PD is a promising drug candidate or nutraceutical for the treatment of VaD and AD.

Uses

Polydatin, a type of polyphenolic phytoalexin, has many physiological and pharmacological effects including anti-inflammatory and anti-oxidative activities. Polydatin is an effective candidate drug for the protection of photo-inflammation. Polydatin exhibits therapeutic potential for vascular dementia, most likely due to its anti-oxidant activity and the direct protection of neurons.

Uses

Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a metabolite, a potassium channel modulator, an anti-arrhythmia drug, a hepatoprotective agent, an antioxidant and a nephroprotective agent. It is a stilbenoid, a polyphenol, a beta-D-glucoside and a monosaccharide derivative. It derives from a trans-resveratrol.

Biological Functions

Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.

Biological Activity

Polydatin is a natural stilbene originally isolated from the rhizome of P. cuspidatum, which is used in traditional Chinese medicine for analgesic, antipyretic, and diuretic effects.Like other stilbenes, this resveratrol glucoside has antioxidant activity.Polydatin has diverse effects in cells, tissues, and animals, including reducing cytotoxicity, inflammation, and atherosclerosis.

Clinical Use

Polydatin (PD, also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, 3,40 ,5-trihydroxystilbene-3-b-D-glucoside) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), a traditional Chinese medicine that has long been used in China as an analgesic, anti-pyretic, diuretic and expectorant. It is a glucoside of resveratrol (3,40 ,5-trihydroxystilbene) in which the glucoside group bound to the position C-3 substitutes a hydroxyl group, belonging to stilbene phytoalexins. Polydatin can also be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin is the most abundant form of resveratrol in nature. Polydatin shows many pharmacological effects confirmed by numerous investigations, including cardiovascular protection, neuroprotection, anti-inflammation, immunoregulation, anti-oxidation, anti-tumour and liver and lung protective effects. Polydatin has found its way into clinical trials for the treatment of hemorrhagic shock and irritable bowel syndrome.

Polydatin Preparation Products And Raw materials

Raw materials

Preparation Products


Polydatin Suppliers

Global( 146)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21751 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8260 58

View Lastest Price from Polydatin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Polydatin
65914-17-2
US $1.00 / kg 1kg 97%-99% as request career henan chemical co

65914-17-2(Polydatin)Related Search:


  • Polydatin
  • (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-(4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,
  • (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-(4-hydroxystyryl)phenoxy)-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Piceid, Reservatrol-3-betta-Mono-D-glucoside, Resveratrol 3-O-betta-D-glucopyranoside
  • Polydatin SynonyMs Piceid, Reservatrol-3-betta-Mono-D-glucoside, Resveratrol 3-O-betta-D-glucopyranoside
  • β-D-Glucopyranoside, 3-hydroxy-5-[2-(4-hydroxyphenyl)ethenyl]phenyl
  • Polydatin 3,4'-5-Trihydroxystilbene-3-beta-D-glucopyranoside
  • 3,4'-5-Trihydroxystilbene-3-beta-D-glucopyranoside 97%
  • -2-(3-Hydroxy-5-(4-hydroxystyryl)
  • (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-(4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran
  • Polydatin(Random Configuration)
  • (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • 4',5-DIHYDROXYSTILBENE-3-O-BETA-D-GLUCOSIDE
  • 3-HYDROXY-5-(2-(4-HYDROXYPHENYL)ETHENYL)PHENYL-BETA-D-GLUCOSIDE
  • 3,4',5-TRIHYDROXYSTILBENE-3-BETA-MONOGLUCOSIDE
  • 3,4'-5-TRIHYDROXYSTILBENE-3-BETA-D-GLUCOPYRANOSIDE
  • TRANS-RESVERATROL 3-O-BETA-D-GLUCURONIDE
  • TRANS-RESVERATROL-O-BETA-GLUCOSIDE
  • PICEID
  • RESVERATROL GLUCOSIDE
  • RESVERATROL 3-BETA-MONO-D-GLUCOSIDE
  • RESVERATROL-3-B-D-GLUCOSIDE
  • 3,4'-5-TRIHYDROXYSTILBEENE-3-BETA-D-GLU&
  • Polydatine
  • 3,4'-5-trihydroxystilbene-3-β-d-glucopyranoside
  • 3,4',5-Trihydroxystilbene-3-b-D-glucopyranoside
  • Polydatain
  • Polydatin
  • 3,5,4''-TRIHYDROXYSTILBENE-3-O-BETA-D-GLUCOPYRANOSIDE
  • Polydatin 98%
  • TRIHYDROXYSTILBENE-3-O-BETA-D-GLUCOPYRANOSIDE, 3,4',5-(RG)
  • Polydatin ,98%
  • Polydatin(Piceid)
  • 3,4',5-Trihydroxystilbene-3-O-beta-D-glucopyranoside
  • 65914-17-2
  • Carbohydrate Synthesis
  • Specialty Synthesis
  • Monosaccharides
  • natural product
  • Inhibitors
  • Natural Plant Extract
  • Improve Organism Immunity
  • Carbohydrate Synthesis
  • Monosaccharides
  • Specialty Synthesis
  • plant extract
  • Herb extract
Copyright 2017 © ChemicalBook. All rights reserved