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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- structure

CAS No.: 5184-64-5

Chemical Name:: Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

Synonyms: ESI-05;NSC 116966;ESI-05 (ESI05);ESI-05 (NSC 116966);ESI-05 >=98% (HPLC);MESITYL P-TOLYL SULFONE;1,3,5-trimethyl-2-tosylbenzene;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-;Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05

CBNumber:: CB83290819

Molecular Formula:: C16H18O2S

Molecular Weight:: 274.38

MDL Number:: MFCD00091573

MOL File:: 5184-64-5.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Properties

Melting point	119-120 °C
Boiling point	426.7±45.0 °C(Predicted)
Density	1.129±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: soluble
form	powder
color	white to beige

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1907	ESI-05 ≥98% (HPLC)	5184-64-5	5mg	$105	2024-03-01	Buy
Sigma-Aldrich	SML1907	ESI-05 ≥98% (HPLC)	5184-64-5	25mg	$424	2024-03-01	Buy
Sigma-Aldrich	S798975	MESITYL P-TOLYL SULFONE AldrichCPR	5184-64-5	50MG	$179	2024-03-01	Buy
Cayman Chemical	29702	ESI-05	5184-64-5	5mg	$93	2024-03-01	Buy
Cayman Chemical	29702	ESI-05	5184-64-5	25mg	$343	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1907	5mg	$105	Buy
SML1907	25mg	$424	Buy
S798975	50MG	$179	Buy
29702	5mg	$93	Buy
29702	25mg	$343	Buy

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties,Uses,Production

Uses

ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.

Biochem/physiol Actions

ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.

storage

Store at RT

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3444	55
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29797	68
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Wuxi Kehua Biological Technology Co., Ltd.	0510-0510-86838766	2258830676@qq.com	China	3823	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
InvivoChem	58
Aladdin Scientific	58
Sigma-Aldrich	80
BOC Sciences	65
Shanghai EFE Biological Technology Co., Ltd.	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Beijing Solarbio Science & Tecnology Co., Ltd.	68
DC Chemicals	58
Wuxi Kehua Biological Technology Co., Ltd.	58

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene MESITYL P-TOLYL SULFONE ESI-05 ESI-05 (ESI05) 1,3,5-trimethyl-2-tosylbenzene NSC 116966 ESI-05 >=98% (HPLC) ESI-05 (NSC 116966) Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05 5184-64-5