ChemicalBook >> CAS DataBase List >>BCI-121
BCI-121
- CAS No.
- 432529-82-3
- Chemical Name:
- BCI-121
- Synonyms
- BCL 121;BCI-121;BCI-121;BCI 121;BCI121;1-Piperidineacetamide, 4-(aminocarbonyl)-N-(4-bromophenyl)-;1-{2-[(4-bromophenyl)amino]-2-oxoethyl}piperidine-4-carboxamide;inhibit,BCI 121,Histone Methyltransferase,Inhibitor,BCI-121,BCI121
- CBNumber:
- CB83339611
- Molecular Formula:
- C14H18BrN3O2
- Molecular Weight:
- 340.22
- MDL Number:
- MFCD02149239
- MOL File:
- 432529-82-3.mol
- MSDS File:
- SDS
Last updated:2023-05-18 11:31:13
| Boiling point | 576.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.474±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMF:30.0(Max Conc. mg/mL);88.18(Max Conc. mM) DMSO:66.0(Max Conc. mg/mL);193.99(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.97(Max Conc. mM) Ethanol:39.0(Max Conc. mg/mL);114.63(Max Conc. mM) |
| pka | 13.82±0.70(Predicted) |
| form | powder |
| color | white to beige |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
BCI-121 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1817 | BCI-121 ≥98% (HPLC) | 432529-82-3 | 5mg | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1817 | BCI-121 ≥98% (HPLC) | 432529-82-3 | 25mg | $464 | 2024-03-01 | Buy |
| ChemScene | CS-B1554 | BCI-121 99.45% | 432529-82-3 | 5mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-B1554 | BCI-121 99.45% | 432529-82-3 | 10mg | $114 | 2021-12-16 | Buy |
| ChemScene | CS-B1554 | BCI-121 99.45% | 432529-82-3 | 25mg | $234 | 2021-12-16 | Buy |
BCI-121 Chemical Properties,Uses,Production
Biochem/physiol Actions
BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level (by 50%/H3K4me2 and 40%H3K4me3 in HT29 cells; 100 μM BCI-121 for 48 h), downregulates known SMYD3 target genes transcription, and selectively affects SMYD3-dependent proliferation of cancer cultures (46%/HT29 and 54%/HCT116 proliferation reduction; 100 μM BCI-121 for 72 h) with little antiproliferation efficacy toward low SMYD3-expressing cancer cells. BCI-121 targets SMYD3 via direct affinity interaction (kon 357.7/M/s; koff 4.23×10-3/s; KD=koff/kon = 11.8 μM) and effectively competes against histone for SMYD3 binding (%inhibition/[histone H4 peptide]:[BCI-121] ratio = 36.5%/1:1 and 51.0%/1:2.5).
BCI-121 Preparation Products And Raw materials
Raw materials
Preparation Products
BCI-121 Suppliers
Global( 45)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
BCI-121
BCI-121;BCI 121;BCI121
1-{2-[(4-bromophenyl)amino]-2-oxoethyl}piperidine-4-carboxamide
1-Piperidineacetamide, 4-(aminocarbonyl)-N-(4-bromophenyl)-
BCL 121
inhibit,BCI 121,Histone Methyltransferase,Inhibitor,BCI-121,BCI121
432529-82-3