WIN 55,212-2 MESYLATE
- CAS No.
- 131543-23-2
- Chemical Name:
- WIN 55,212-2 MESYLATE
- Synonyms
- WIN55;CS-754;WIN 55,212-2;212-2Mesylate;WIN552122;WIN-552122;WIN 55,212-2 MESYLATE;R(+)-WIN 55,212-2 MESYLATE;WIN 55212-2 methanesulfonate;(R)-(+)-WIN 55,212-2 mesylate salt;WIN552122;WIN-552122;(R)-(+)-WIN 55212
- CBNumber:
- CB8335502
- Molecular Formula:
- C28H30N2O6S
- Molecular Weight:
- 522.62
- MDL Number:
- MFCD00153882
- MOL File:
- 131543-23-2.mol
- MSDS File:
- SDS
storage temp. | Store at +4°C |
---|---|
solubility | 0.1 M HCl: 0.25 mg/mL |
form | solid |
color | white to off-white |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
InChIKey | FSGCSTPOPBJYSX-OZYVVJTJNA-N |
SMILES | S(O)(=O)(=O)C.C(N1CCOCC1)[C@@H]1COC2=CC=CC3C(C(C4=CC=CC5=CC=CC=C45)=O)=C(C)N1C=32 |&1:12,r| |
FDA UNII | 2J851TP7VJ |
WIN 55,212-2 MESYLATE price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | W102 | (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) | 131543-23-2 | 25mg | $446 | 2024-03-01 | Buy |
Sigma-Aldrich | W102 | (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) | 131543-23-2 | 100mg | $910 | 2024-03-01 | Buy |
Cayman Chemical | 10009023 | (+)-WIN 55,212-2 (mesylate) ≥98% | 131543-23-2 | 5mg | $46 | 2024-03-01 | Buy |
Cayman Chemical | 10009023 | (+)-WIN 55,212-2 (mesylate) ≥98% | 131543-23-2 | 10mg | $88 | 2024-03-01 | Buy |
Cayman Chemical | 10009023 | (+)-WIN 55,212-2 (mesylate) ≥98% | 131543-23-2 | 25mg | $195 | 2024-03-01 | Buy |
WIN 55,212-2 MESYLATE Chemical Properties,Uses,Production
Description
(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 μM.
Uses
(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.
General Description
WIN 55,212-2 is a member of the aminoalkylindole class of compounds.
Biological Activity
Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .
Biochem/physiol Actions
It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.
storage
Store at +4°C
References
1) Felder?et al. (1995),?Comparison of the pharmacology and signal transduction of the human cannabinoid CB1?and CB2receptors; Mol. Pharmacol.,?48?443 2) Herzberg?et al. (1997),?The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett.,?221?157 3) Bouaboula?et al. (1995),?Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J.,?312?637
WIN 55,212-2 MESYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7192 | 58 |
View Lastest Price from WIN 55,212-2 MESYLATE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-15 | (+)-Win 55212-2 mesylate
131543-23-2
|
US $0.00 / G | 10G | 0.99 | 1000g | Hebei Yanxi Chemical Co., Ltd. | ||
2024-05-11 | WIN 55212-2 mesylate
131543-23-2
|
US $20.00-10.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD | ||
2024-05-11 | WIN 55212-2 mesylate
131543-23-2
|
US $9.00-60.00 / g | 10g | min99% | 10 tons | Hebei Kangcang new material Technology Co., LTD |
- (+)-Win 55212-2 mesylate
131543-23-2
- US $0.00 / G
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
- WIN 55212-2 mesylate
131543-23-2
- US $20.00-10.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD
- WIN 55212-2 mesylate
131543-23-2
- US $9.00-60.00 / g
- min99%
- Hebei Kangcang new material Technology Co., LTD
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