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4-Methylsulphonylphenylacetic acid

4-Methylsulphonylphenylacetic acid structure

CAS No.: 90536-66-6

Chemical Name:: 4-Methylsulphonylphenylacetic acid

Synonyms: TIMTEC-BB SBB009970;Etoricoxib?USP RC B;Etocoxib impurity 2;4-(Methylsulfonyl)ph;Etoricoxib impurity M;OTHER BUILDING BLOCKS;Etoricoxib Impurity 28;4-MESYLPHENYLACETIC ACID;4-Mesylbenzeneacetic acid;Etoricoxib Intermediate 5

CBNumber:: CB8339797

Molecular Formula:: C9H10O4S

Molecular Weight:: 214.24

MDL Number:: MFCD00216495

MOL File:: 90536-66-6.mol

MSDS File:: SDS

Last updated:2024-04-19 20:05:26

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4-Methylsulphonylphenylacetic acid Properties

Melting point	136-140 °C(lit.)
Boiling point	324.37°C (rough estimate)
Density	1.4230 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.90±0.10(Predicted)
color	White to Pale Yellow
Water Solubility	slight
BRN	2646649
CAS DataBase Reference	90536-66-6(CAS DataBase Reference)
FDA UNII	C39I2W89XI

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P305+P351+P338

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

Hazard Note

Irritant

HS Code

29309090

NFPA 704

	0
2		0

4-Methylsulphonylphenylacetic acid price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	579114	4-(Methylsulfonyl)phenylacetic acid 97%	90536-66-6	1g	$20	2023-06-20	Buy
Sigma-Aldrich	579114	4-(Methylsulfonyl)phenylacetic acid 97%	90536-66-6	5g	$21	2023-06-20	Buy
TCI Chemical	M1899	4-(Methylsulfonyl)phenylacetic Acid >98.0%(T)	90536-66-6	1g	$28	2024-03-01	Buy
TCI Chemical	M1899	4-(Methylsulfonyl)phenylacetic Acid >98.0%(T)	90536-66-6	5g	$83	2024-03-01	Buy
Alfa Aesar	L19504	4-(Methylsulfonyl)phenylacetic acid, 97%	90536-66-6	5g	$51.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
579114	1g	$20	Buy
579114	5g	$21	Buy
M1899	1g	$28	Buy
M1899	5g	$83	Buy
L19504	5g	$51.65	Buy

4-Methylsulphonylphenylacetic acid Chemical Properties,Uses,Production

Chemical Properties

yellow to beige-brown crystalline powder

Uses

4-(Methylsulfonyl)phenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Preparation

synthesis of 4-(Methylsulfonyl)phenylacetic acid: 1-(4-Methanesulfonyl-phenyl)-ethanone (20 mmol), morpholine (60 mmol) and elemental sulfur (40 mmol) were added in a round-bottom flask and refluxed for 2 h at 398 K. A 3N solution of NaOH (20 ml) was then added, and the reaction mixture refluxed for an additional 30 min. After cooling, the mixture was filtered and the filtrate was acidified with HCl to pH 6. The solution was again filtered off and washed with ethyl acetate. The resulting aqueous fraction was finally acidified with diluted HCl, to yield the pure product as a white solid. Crystals suitable for X-ray analysis were obtained by slow evaporation of an ethanol/water (1:1 v/v) solution.

Application

4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.

4-Methylsulphonylphenylacetic acid synthesis

Synthesis of 4-Methylsulphonylphenylacetic acid from 2-(4-methylsulfanylphenyl)acetaldehyde

4-Methylsulphonylphenylacetic acid Preparation Products And Raw materials

Raw materials

2-(4-methylsulfanylphenyl)acetaldehyde 4-Methylsulphonylacetophenone METHYL 2-(4-(METHYLSULFONYL)PHENYL)ACETATE 4-Methylthiophenylacetic acid 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE

4'-Methylthioacetophenone 4-(Methylthio)benzaldehyde

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Preparation Products

Etoricoxib Impurity 8

4-Methylsulphonylphenylacetic acid Suppliers

Global( 339)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	1175	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	298	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55

Supplier	Advantage
sgtlifesciences pvt ltd	58
Coresyn Pharmatech Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Guanlang Biotechnology Co,.LTD	58
Anhui Ruihan Technology Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Shanghai Bojing Chemical Co.,Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 4-Methylsulphonylphenylacetic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-20	4-Methylsulphonylphenylacetic acid 90536-66-6	US $50.00 / kg	1kg	99.10%	5000kg	Ouhuang Engineering Materials (Hubei) Co., Ltd
2023-09-11	4-Methylsulphonylphenylacetic acid 90536-66-6	US $50.00 / kg	1kg	99%	10000tons	Anhui Ruihan Technology Co., Ltd
2023-09-07	4-(Methylsulfonyl)phenylacetic acid 90536-66-6	US $1.00 / kg	1kg	99%	20tons	Hebei Yanxi Chemical Co., Ltd.

4-Methylsulphonylphenylacetic acid
90536-66-6
US $50.00 / kg
99.10%
Ouhuang Engineering Materials (Hubei) Co., Ltd

4-Methylsulphonylphenylacetic acid
90536-66-6
US $50.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

4-(Methylsulfonyl)phenylacetic acid
90536-66-6
US $1.00 / kg
99%
Hebei Yanxi Chemical Co., Ltd.

90536-66-6(4-Methylsulphonylphenylacetic acid)Related Search:

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Methyl 2-methylnicotinate 4-(METHYLSULFONYL)PHENYLACETONITRILE Etoricoxib Impurity 18 4-Hydroxyphenylacetic acid

Phenethyl phenylacetate 4-Methoxyphenylacetic acid 2-Hydroxyphenylacetic acid 2-Methylphenylacetic acid Etoricoxib

Etoricoxib Impurity 15 (Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime Etoricoxib Impurity 31 Etoricoxib iMpurity 1 Etoricoxib IMpurity

Etoricoxib Impurity 7 Etoricoxib impurity 22 Etoricoxib Impurity 9

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TIMTEC-BB SBB009970 4-MESYLPHENYLACETIC ACID 4-(METHANESULFONYL)PHENYLACETIC ACID 4-METHYLSULPHONYLPHENYLACETIC ACID 4-(METHYLSULFONYL)PHENYLACETIC ACID 4-methylsulfonyl benzeneacetic acid 4-(Methylsulfonyl)PhenylAceticAcid,Etoricoxib 4-Methyl Sulphonile Phenyle Acetic Acid 4-(Methanesulfonyl)phenylaceticacid,97% 4-Methylsulfonylphenylacetic Benzeneacetic acid, 4-(methylsulfonyl)- 4-Mesylbenzeneacetic acid 4-Methylsulphonylphenylacetic acid,95% 4-(Methylsulfonyl)ph 4-(Carboxymethyl)phenyl methyl sulphone Etoricoxib Related CoMpound B Etoricoxib impurity M 4-(Methylsulfonyl)phenylacetic acid 97% Etoricoxib USP Related Compound B 2-(4-methylsulfonylphenyl)acetate Etoricoxib?USP RC B Etoricoxib Intermediate 5 Etoricoxib Impurity 28 4-(Methylsulfonyl)phenylaceticAcid> OTHER BUILDING BLOCKS 4-(Methylsulfonyl)phenylacetic Acid (Int of Etoricoxib) Etocoxib impurity 2 90536-66-6 35230-23-1 C9H10O4S H3CSO2C6H4CH2CO2H Carboxylic acid Carboxylic Acids Chemical Synthesis Organic Building Blocks C9 Carbonyl Compounds Carboxylic Acids Building Blocks Carbonyl Compounds