C2 CERAMIDE
- CAS No.
- 3102-57-6
- Chemical Name:
- C2 CERAMIDE
- Synonyms
- N-ACETYLSPHINGOSINE;N-ACETYL-D-SPHINGOSINE;N-ETHANOYL-D-ERYTHRO-SPHINGOSINE;CERAMIDE C2;C2 CERAMIDE;C2:0 CERAMIDE;TOC Ceramide;ACETYL CERAMIDE;C14 SPHINGOID BASE;N-Acetylsphigosine
- CBNumber:
- CB8342539
- Molecular Formula:
- C20H39NO3
- Molecular Weight:
- 341.53
- MDL Number:
- MFCD00153903
- MOL File:
- 3102-57-6.mol
- MSDS File:
- SDS
Melting point | 93-96 °C |
---|---|
Boiling point | 477.13°C (rough estimate) |
Density | 1.0283 (rough estimate) |
refractive index | 1.5614 (estimate) |
storage temp. | −20°C |
solubility | DMSO: soluble |
pka | 13.50±0.20(Predicted) |
form | powder |
color | white |
Stability | Moisture Sensitive |
FDA UNII | 8YTC7R47CW |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
HS Code | 29241990 |
C2 CERAMIDE price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 01912 | N-Acetyl-D-sphingosine ≥98.0% (TLC) | 3102-57-6 | 50mg | $101.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 01912 | N-Acetyl-D-sphingosine ≥98.0% (TLC) | 3102-57-6 | 250mg | $342.8 | 2024-03-01 | Buy |
Alfa Aesar | J60534 | N-Acetyl-D-sphingosine, 98% | 3102-57-6 | 5mg | $112 | 2023-06-20 | Buy |
Alfa Aesar | J60534 | N-Acetyl-D-sphingosine, 98% | 3102-57-6 | 1mg | $20.5 | 2021-12-16 | Buy |
Cayman Chemical | 62510 | C-2 Ceramide ≥98% | 3102-57-6 | 1mg | $21 | 2024-03-01 | Buy |
C2 CERAMIDE Chemical Properties,Uses,Production
Description
C2 ceramide is a cell-
Chemical Properties
White Crystalline Solid
Uses
A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2
Uses
Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases
Definition
ChEBI: N-acetylsphingosine is a N-acylsphingosine that has an acetamido group at position 2.
Biological Activity
A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro .
Biochem/physiol Actions
Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.
storage
Desiccate at -20°C
References
1) Minano et al. (2008), C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3; J. Neurosci. Res., 86 1734 2) Prinetti et al. (1997), Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells; FEBS Lett., 414 475 3) Zhang et al. (1997), Kinase suppressor of Ras is ceramide-activated protein kinase; Cell, 89 63 4) Matsuzaka et al. (2016) Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation] 5) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]
C2 CERAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
C2 CERAMIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9589 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Shanghai Hengmao New Materials Technology CO., LIMITED | +86-0086-1773693-3208 +8617736933208 | 1137059254@qq.com | China | 9287 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50001 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Renshi Pharmatech Co., LTD | 021-26018649 17721318029 | info@renshipharma.com | China | 107 | 55 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006608290; 18621169109 | market03@meryer.com | China | 40241 | 62 |
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