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C2 CERAMIDE

CAS No.
3102-57-6
Chemical Name:
C2 CERAMIDE
Synonyms
N-ACETYLSPHINGOSINE;N-ACETYL-D-SPHINGOSINE;N-ETHANOYL-D-ERYTHRO-SPHINGOSINE;CERAMIDE C2;C2 CERAMIDE;C2:0 CERAMIDE;TOC Ceramide;ACETYL CERAMIDE;C14 SPHINGOID BASE;N-Acetylsphigosine
CBNumber:
CB8342539
Molecular Formula:
C20H39NO3
Molecular Weight:
341.53
MDL Number:
MFCD00153903
MOL File:
3102-57-6.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00

C2 CERAMIDE Properties

Melting point 93-96 °C
Boiling point 477.13°C (rough estimate)
Density 1.0283 (rough estimate)
refractive index 1.5614 (estimate)
storage temp. −20°C
solubility DMSO: soluble
pka 13.50±0.20(Predicted)
form powder
color white
Stability Moisture Sensitive
FDA UNII 8YTC7R47CW

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3
HS Code  29241990

C2 CERAMIDE price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 01912 N-Acetyl-D-sphingosine ≥98.0% (TLC) 3102-57-6 50mg $101.6 2024-03-01 Buy
Sigma-Aldrich 01912 N-Acetyl-D-sphingosine ≥98.0% (TLC) 3102-57-6 250mg $342.8 2024-03-01 Buy
Alfa Aesar J60534 N-Acetyl-D-sphingosine, 98% 3102-57-6 5mg $112 2023-06-20 Buy
Alfa Aesar J60534 N-Acetyl-D-sphingosine, 98% 3102-57-6 1mg $20.5 2021-12-16 Buy
Cayman Chemical 62510 C-2 Ceramide ≥98% 3102-57-6 1mg $21 2024-03-01 Buy
Product number Packaging Price Buy
01912 50mg $101.6 Buy
01912 250mg $342.8 Buy
J60534 5mg $112 Buy
J60534 1mg $20.5 Buy
62510 1mg $21 Buy

C2 CERAMIDE Chemical Properties,Uses,Production

Description

C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.

Chemical Properties

White Crystalline Solid

Uses

A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2

Uses

Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases

Definition

ChEBI: N-acetylsphingosine is a N-acylsphingosine that has an acetamido group at position 2.

Biological Activity

A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro .

Biochem/physiol Actions

Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.

storage

Desiccate at -20°C

References

1) Minano et al. (2008), C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3; J. Neurosci. Res., 86 1734 2) Prinetti et al. (1997), Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells; FEBS Lett., 414 475 3) Zhang et al. (1997), Kinase suppressor of Ras is ceramide-activated protein kinase; Cell, 89 63 4) Matsuzaka et al. (2016) Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation] 5) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]

C2 CERAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

C2 CERAMIDE Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9589 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Shanghai Hengmao New Materials Technology CO., LIMITED
+86-0086-1773693-3208 +8617736933208 1137059254@qq.com China 9287 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 50001 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Shanghai Renshi Pharmatech Co., LTD 021-26018649 17721318029 info@renshipharma.com China 107 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006608290; 18621169109 market03@meryer.com China 40241 62

C2 CERAMIDE Spectrum

N-ACETYL-D-ERYTHRO-SPHINGOSINE N-ACETYLSPHINGOSINE, D-ERYTHRO C14 SPHINGOID BASE C2:0 CERAMIDE C2-D-ERYTHRO-CERAMIDE C2 CERAMIDE C2 CERAMIDE OF D-ERYTHRO-C14-SPHINGOSINE CERAMIDE C2 D-ERYTHRO-SPHINGOSINE, N-ACETYL- ACETYL CERAMIDE N-ETHANOYL-D-ERYTHRO-SPHINGOSINE SYNTHE TICAL 99+% N-Ethanoyl-D-erythro-sphingosine, synthetical (D-erythro-N-Acetylsphingosine) D-erythro-Sphingoshine, N-Acetyl- N-Ethanoyl-D-sphingosine TOC Ceramide Acetyl ceramide, C2 ceramide N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxyMethyl)-3-heptadecen-1-yl]acetaMide (2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol C2 Ceramide (d18:1/2:0) Acetamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]- D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem N-Acetylsphigosine N-ACETYLSPHINGOSINE N-ACETYL-D-SPHINGOSINE N-ETHANOYL-D-ERYTHRO-SPHINGOSINE C2 Ceramide,C-2 Ceramide 3102-57-6 3102-57-5 7344-2-7 3101-57-6 BioChemical Anti-Proliferative Agents Antitumor Agents Cancer Research Mixed Fatty Acids Activators Fatty Acid Derivatives & Lipids Glycerols Inhibitors Protein Kinase Inhibitors and Activators Lipid signaling