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METHYL 6-AMINO-5-BROMOPICOLINATE

METHYL 6-AMINO-5-BROMOPICOLINATE structure

CAS No.: 178876-82-9

Chemical Name:: METHYL 6-AMINO-5-BROMOPICOLINATE

Synonyms: methyl 6-amino-5-bromopicolinate;METHYL 6-AMINO-5-BROMOPYRIDINE-2-CARBOXYLATE;METHYL 6-AMINO-5-BROMOPICOLINATE ISO 9001：2015 REACH;6-AMino-5-broMopyridine-2-carboxylic Acid Methyl Ester;2-Pyridinecarboxylic acid, 6-amino-5-bromo-, methyl ester

CBNumber:: CB8348980

Molecular Formula:: C7H7BrN2O2

Molecular Weight:: 231.05

MDL Number:: MFCD08062950

MOL File:: 178876-82-9.mol

MSDS File:: SDS

Last updated:2025-10-14 17:29:05

Product description	Number	Pack Size	Price
6-Amino-5-bromopyridine-2-carboxylicAcidMethylEster	A601910	250mg	$155
6-Amino-5-bromopyridine-2-carboxylicAcidMethylEster	A601910	2.5g	$1230
Methyl 6-amino-5-bromopicolinate 95%	153558	5g	$1480
METHYL-6-AMINO-5-BROMO PICOLINATE 95.00%	HCH0029340	2.5G	$1947
METHYL-6-AMINO-5-BROMO PICOLINATE 95.00%	HCH0029340	80G	$26720
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METHYL 6-AMINO-5-BROMOPICOLINATE Properties

Melting point	143-145 °C
Boiling point	359.2±37.0 °C(Predicted)
Density	1.662
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	-0.23±0.10(Predicted)
Appearance	Light yellow to yellow Solid
InChI	InChI=1S/C7H7BrN2O2/c1-12-7(11)5-3-2-4(8)6(9)10-5/h2-3H,1H3,(H2,9,10)
InChIKey	OQUCMNQHZFOMPC-UHFFFAOYSA-N
SMILES	C1(C(OC)=O)=NC(N)=C(Br)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
HS Code	2933399990

METHYL 6-AMINO-5-BROMOPICOLINATE price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A601910	6-Amino-5-bromopyridine-2-carboxylicAcidMethylEster	178876-82-9	250mg	$155	2021-12-16	Buy
TRC	A601910	6-Amino-5-bromopyridine-2-carboxylicAcidMethylEster	178876-82-9	2.5g	$1230	2021-12-16	Buy
Matrix Scientific	153558	Methyl 6-amino-5-bromopicolinate 95%	178876-82-9	5g	$1480	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0029340	METHYL-6-AMINO-5-BROMO PICOLINATE 95.00%	178876-82-9	2.5G	$1947	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0029340	METHYL-6-AMINO-5-BROMO PICOLINATE 95.00%	178876-82-9	80G	$26720	2021-12-16	Buy

Product number	Packaging	Price	Buy
A601910	250mg	$155	Buy
A601910	2.5g	$1230	Buy
153558	5g	$1480	Buy
HCH0029340	2.5G	$1947	Buy
HCH0029340	80G	$26720	Buy

METHYL 6-AMINO-5-BROMOPICOLINATE Chemical Properties,Uses,Production

Uses

Methyl 6-amino-5-bromopicolinate is used in the preparation of aminopyridinamides as sodium channel modulators.

Synthesis

36052-26-3

178876-83-0

178876-82-9

d) Synthesis of methyl 6-amino-5-bromopyridine-2-carboxylate: Methyl 6-aminopyridine-2-carboxylate (10 g, 66.0 mmol) was dissolved in chloroform (450 mL) at room temperature, and a chloroform (100 mL) solution of bromine (3.4 mL, 66.0 mmol) was slowly added. The reaction mixture was stirred for 40 hours, then diluted with chloroform and washed sequentially with saturated sodium thiosulfate solution and water. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography using ethyl acetate/hexane as eluent to afford methyl 5-bromo-6-aminopyridine-2-carboxylate as a yellow solid (3.3 g, 22% yield).MS ESI (m/e): 231.0 [(M + H)+].1H NMR (CDCl3, 400 MHz): δ ( ppm) = 7.76 (d, J = 7.88 Hz, 1H), 7.34 (d, J = 7.92 Hz, 1H), 5.23 (s, 2H), 3.94 (s, 3H). (d) Isolation of methyl 6-amino-3-bromopyridine-2-carboxylate: In step d), the isomer methyl 6-amino-3-bromopyridine-2-carboxylate was isolated as a by-product to give methyl 6-amino-3-bromopyridine-2-carboxylate (3.0 g, 19% yield).MS ESI (m/e): 231.2 [(M + H)+].1H NMR (CDCl3, 400 MHz): δ (ppm) = 7.60 (d , J = 8.72 Hz, 1H), 6.47 (d, J = 7.88 Hz, 1H), 4.71 (s, 2H), 3.94 (s, 3H).

References

[1] Journal of Organic Chemistry, 1996, vol. 61, # 14, p. 4623 - 4633
[2] Organic Process Research and Development, 2010, vol. 14, # 1, p. 263 - 271
[3] Tetrahedron Letters, 2010, vol. 51, # 38, p. 5035 - 5037
[4] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2011/92272, 2011, A1. Location in patent: Page/Page column 129; 130

METHYL 6-AMINO-5-BROMOPICOLINATE Preparation Products And Raw materials

Raw materials

6-AMINOPICOLINIC ACID METHYL ESTER Methanol N-(3-bromo-6-methylpyridin-2-yl)acetamide Chloroform

Preparation Products

Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

METHYL 6-AMINO-5-BROMOPICOLINATE Suppliers

Global( 104)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Suzhou Victorypharm Co.,Ltd.	+86-13916956214	sales@victory-pharm.com	China	1299	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Labnetwork lnc.	58
Suzhou Victorypharm Co.,Ltd.	58

View Lastest Price from METHYL 6-AMINO-5-BROMOPICOLINATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	methyl 6-amino-5-bromo-pyridine-2-carboxylate 178876-82-9	US $1.10-9.90 / KG	1KG	99% min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-06-25	METHYL 6-AMINO-5-BROMOPICOLINATE 178876-82-9	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2020-01-03	METHYL 6-AMINO-5-BROMOPICOLINATE 178876-82-9	US $1.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

methyl 6-amino-5-bromo-pyridine-2-carboxylate
178876-82-9
US $1.10-9.90 / KG
99% min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

METHYL 6-AMINO-5-BROMOPICOLINATE
178876-82-9
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

METHYL 6-AMINO-5-BROMOPICOLINATE
178876-82-9
US $1.00 / KG
99%
Career Henan Chemical Co

METHYL 6-AMINO-5-BROMOPICOLINATE Spectrum

METHYL 6-AMINO-5-BROMOPICOLINATE(178876-82-9)¹HNMR METHYL 6-AMINO-5-BROMOPICOLINATE(178876-82-9)FT-IR

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methyl 6-amino-5-bromopicolinate 6-AMino-5-broMopyridine-2-carboxylic Acid Methyl Ester METHYL 6-AMINO-5-BROMOPYRIDINE-2-CARBOXYLATE 2-Pyridinecarboxylic acid, 6-amino-5-bromo-, methyl ester METHYL 6-AMINO-5-BROMOPICOLINATE ISO 9001：2015 REACH 178876-82-9 C7H7N2O2Br Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals