3-Chloro-2-fluorobenzoic acid
- CAS No.
- 161957-55-7
- Chemical Name:
- 3-Chloro-2-fluorobenzoic acid
- Synonyms
- CAS:161957-55-7;BUTTPARK 14\01-29;RARECHEM AL BO 1303;3-Chloro-2-Fluorobenzoic;2-FLUORO-3-CHLOROBENZOIC ACID;3-CHLORO-2-FLUOROBENZOIC ACID;3-Chloro-2-fluoroboronic acid;3-Chloro-2-fluorobenzoicacid98%;Benzoic acid, 3-chloro-2-fluoro-;3-Chloro-2-fluorobenzoic Acid >
- CBNumber:
- CB8350200
- Molecular Formula:
- C7H4ClFO2
- Molecular Weight:
- 174.56
- MDL Number:
- MFCD00042506
- MOL File:
- 161957-55-7.mol
- MSDS File:
- SDS
| Melting point | 177-180 °C (lit.) |
|---|---|
| Boiling point | 278.9±20.0 °C(Predicted) |
| Density | 1.477±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 2.90±0.10(Predicted) |
| color | White to Light yellow to Light red |
| BRN | 7127637 |
| InChI | InChI=1S/C7H4ClFO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11) |
| InChIKey | FCSSYEWURMTUSM-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC(Cl)=C1F |
| CAS DataBase Reference | 161957-55-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
3-Chloro-2-fluorobenzoic acid price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 536318 | 3-Chloro-2-fluorobenzoic acid 98% | 161957-55-7 | 1g | $36.1 | 2023-06-20 | Buy |
| TCI Chemical | C2117 | 3-Chloro-2-fluorobenzoic Acid >97.0%(GC)(T) | 161957-55-7 | 5g | $21 | 2025-07-31 | Buy |
| TCI Chemical | C2117 | 3-Chloro-2-fluorobenzoic Acid >97.0%(GC)(T) | 161957-55-7 | 25g | $83 | 2025-07-31 | Buy |
| TRC | C585648 | 3-Chloro-2-fluorobenzoic Acid | 161957-55-7 | 100mg | $75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0019745 | 2-FLUORO-3-CHLOROBENZOIC ACID 95.00% | 161957-55-7 | 5G | $791.18 | 2021-12-16 | Buy |
3-Chloro-2-fluorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 881, 1995 DOI: 10.1016/0040-4039(94)02385-O
Synthesis
85070-48-0
161957-55-7
General procedure for the synthesis of 3-chloro-2-fluorobenzoic acid from 3-chloro-2-fluorobenzaldehyde: An acetone (75 mL) solution of 3-chloro-2-fluorobenzaldehyde (3 g, 18.92 mmol) was slowly added to an aqueous (30 mL) solution of sodium chlorite (6.81 g, 75.68 mmol) under cooling conditions in an ice bath. The reaction mixture was stirred at 0°C for 5 minutes. Subsequently, sulfamic acid (5.50 g, 56.76 mmol) was added all at once and stirring was continued for 30 min at the same temperature. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was diluted with water (5 mL) and filtered. The filtrate was extracted with ethyl acetate (3 x 50 mL), the organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3-chloro-2-fluorobenzoic acid as a white solid (3.2 g, 97% yield).LC-MS analysis: 172.9 (M-H).
References
[1] Patent: WO2017/72062, 2017, A1. Location in patent: Page/Page column 166
[2] Patent: WO2008/7149, 2008, A2. Location in patent: Page/Page column 28
3-Chloro-2-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 925 | 55 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
View Lastest Price from 3-Chloro-2-fluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-23 | 3-Chloro-2-fluorobenzoic acid
161957-55-7
|
US $230.00 / KG | 1KG | 99% | 300 Tons/ year | Speranza Chemical Co., Ltd. | |
 |
2025-05-23 | 3-Chloro-2-Fluorobenzoic Acid
161957-55-7
|
US $99.00-45.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-01-03 | 3-Chloro-2-fluorobenzoic acid
161957-55-7
|
US $0.00-0.00 / KG | 1g | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-Chloro-2-fluorobenzoic acid
161957-55-7
- US $230.00 / KG
- 99%
- Speranza Chemical Co., Ltd.
-
- 3-Chloro-2-Fluorobenzoic Acid
161957-55-7
- US $99.00-45.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 3-Chloro-2-fluorobenzoic acid
161957-55-7
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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