(S)-(+)-Ketoprofen
- CAS No.
- 22161-81-5
- Chemical Name:
- (S)-(+)-Ketoprofen
- Synonyms
- Dexketoprofen;(S)-KETOPROFEN;(2S)-2-(3-Benzoylphenyl)propanoic acid;Keral;Dexktoprofen;Dexketoprofe;exketoprofen;(+)-Ketoprofen;Dexketoprofen API;(S)-(+)-KETOPROFEN
- CBNumber:
- CB8356545
- Molecular Formula:
- C16H14O3
- Molecular Weight:
- 254.28
- MDL Number:
- MFCD00673316
- MOL File:
- 22161-81-5.mol
- MSDS File:
- SDS
| Melting point | 75-78 °C(lit.) |
|---|---|
| Boiling point | 431.3±28.0 °C(Predicted) |
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | insoluble in H2O; ≥10.6 mg/mL in DMSO; ≥20.55 mg/mL in EtOH |
| form | White solid. |
| pka | 4.23±0.10(Predicted) |
| optical activity | [α]22/D +49°, c = 1 in methanol |
| CAS DataBase Reference | 22161-81-5(CAS DataBase Reference) |
| FDA UNII | 6KD9E78X68 |
| ATC code | M01AE17,M02AA27 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335-H400 | |||||||||
| Precautionary statements | P273-P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-36/37/38-50/53-25 | |||||||||
| Safety Statements | 26-60-61-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CY1572790 | |||||||||
| NFPA 704 |
|
(S)-(+)-Ketoprofen price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 471909 | (S)-(+)-Ketoprofen AldrichCPR | 22161-81-5 | 1g | $136 | 2024-03-01 | Buy |
| Cayman Chemical | 16407 | (S)-Ketoprofen ≥98% | 22161-81-5 | 1g | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 16407 | (S)-Ketoprofen ≥98% | 22161-81-5 | 5g | $305 | 2024-03-01 | Buy |
| Cayman Chemical | 16407 | (S)-Ketoprofen ≥98% | 22161-81-5 | 100mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16407 | (S)-Ketoprofen ≥98% | 22161-81-5 | 500mg | $63 | 2024-03-01 | Buy |
(S)-(+)-Ketoprofen Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Anti-inflammatory; analgesic
Uses
COX inhibitor
Definition
ChEBI: A monocarboxylic acid that is (S)-hydratropic acid substituted at position 3 on the phenyl ring by a benzoyl group. A cyclooxygenase inhibitor, it is used to relieve short-term pain, such as muscular pain, dental pain and dysmenorrhoea.
Biological Activity
(s)-ketoprofen, a dual cox1/2 inhibitor, can be used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains. ketoprofen is photolabile and undergoes degradation when irradiated by sunlight to induce various skin diseases [1].
in vitro
the combination of uvb irradiation with ketoprofen dose-dependently induced the cytotoxicity and suppressed dna synthesis in hacat cells. uvb-irradiated kp inhibited the cell growth and induced g2/m cell cycle arrest by regulating the levels of cdc2, cyclin b1, chk1, tyr15-phosphorylated cdc2 and p21. the dapi staining results has revealed that kp accentuated the apoptotic response to uvb radiation in hacat cells [1].
in vivo
in a placebo-controlled, double-blind study in the rhesus monkeys macaca mulatta with periodontal disease, administeration of kp at 1% level in suitable topical vehicles to the gingiva once daily at a standard dose of 1.8 ml per monkey for 6 months effectively inhibited gcf-ltb4 and gcf-pge2 and positively altered alveolar bone activity [2]. ketoprofen at a dose of 3.63 mg/kg bwt (phenylbutazone equimolar dose) showed significant analgesic effects and reduced hoof pain and lameness to a greater extent [3]. treatment with ketoprofen (40 and 80 mg/kg diet) greatly reduced the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice [4].
Drug interactions
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists:
antagonism of hypotensive effect; increased risk of
nephrotoxicity and hyperkalaemia
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possibly increased risk of convulsions
with quinolones
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparins, dabigatran and edoxaban -
avoid long term use with edoxaban
Antidepressants: increased risk of bleeding with
SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin
concentration.
Antivirals: increased risk of haematological toxicity
with zidovudine; concentration possibly increased by
ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate;
increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity;
antagonism of diuretic effect, hyperkalaemia with
potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding
Probenecid: excretion reduced by probenecid.
Tacrolimus: increased risk of nephrotoxicity
Metabolism
Dexketoprofen is the S-enantiomer of ketoprofen.The main elimination route for dexketoprofen is glucuronide conjugation in the liver followed by renal excretion.
References
[1]. liu s, mizu h, yamauchi h. molecular response to phototoxic stress of uvb-irradiated ketoprofen through arresting cell cycle in g2/m phase and inducing apoptosis[j]. biochemical and biophysical research communications, 2007, 364(3): 650-655.
[2]. li k l, vogel r, jeffcoat m k, et al. the effect of ketoprofen creams on periodontal disease in rhesus monkeys[j]. journal of periodontal research, 1996, 31(8): 525-532.
[3]. owens j g, kamerling s g, stanton s r, et al. effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse[j]. equine veterinary journal, 1995, 27(4): 296-300.
[4]. hawk e t, kelloff g j, mccormick d l. differential activity of aspirin, ketoprofen and sulindac as cancer chemopreventive agents in the mouse urinary bladder[j]. carcinogenesis, 1996, 17(5): 1435-1438.
(S)-(+)-Ketoprofen Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2504 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12377 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from (S)-(+)-Ketoprofen manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | (S)-(+)-Ketoprofen
22161-81-5
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2023-08-21 | (S)-(+)-Ketoprofen
22161-81-5
|
US $100.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD | |
 |
2021-09-29 | (S)-(+)-Ketoprofen
22161-81-5
|
US $0.00 / Kg/Drum | 1KG | 98.5%-101% | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- (S)-(+)-Ketoprofen
22161-81-5
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- (S)-(+)-Ketoprofen
22161-81-5
- US $100.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD
-
- (S)-(+)-Ketoprofen
22161-81-5
- US $0.00 / Kg/Drum
- 98.5%-101%
- WUHAN FORTUNA CHEMICAL CO., LTD
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