APOMORPHINE HYDROCHLORIDE
- CAS No.
- 314-19-2
- Chemical Name:
- APOMORPHINE HYDROCHLORIDE
- Synonyms
- (r)-id;UPRIMA;TAK251);KW-6500;R(–)-APO;NSC 11442;APL130277;(theta)-id;APL 130277;APL-130277
- CBNumber:
- CB8357092
- Molecular Formula:
- C17H18ClNO2
- Molecular Weight:
- 303.78
- MDL Number:
- MFCD00069236
- MOL File:
- 314-19-2.mol
- MSDS File:
- SDS
| Melting point | >250℃ |
|---|---|
| storage temp. | Store at RT |
| solubility | ≥1.08 mg/mL in EtOH with ultrasonic; ≥12.9 mg/mL in DMSO; ≥5.12 mg/mL in H2O |
| form | solid |
| FDA UNII | 9K13MD7A0D |
| EPA Substance Registry System | Apomorphine hydrochloride (314-19-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H334-H312-H332-H317 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501 | |||||||||
| RIDADR | 3249 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | mmo-sat 20 mg/plate MUREAV 137,17,84 | |||||||||
| NFPA 704 |
|
APOMORPHINE HYDROCHLORIDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16094 | (-)-Apomorphine (hydrochloride) ≥95% | 314-19-2 | 10mg | $25 | 2021-12-16 | Buy |
| Cayman Chemical | 16094 | (-)-Apomorphine (hydrochloride) ≥95% | 314-19-2 | 50mg | $56 | 2021-12-16 | Buy |
| Cayman Chemical | 16094 | (-)-Apomorphine (hydrochloride) ≥95% | 314-19-2 | 100mg | $100 | 2021-12-16 | Buy |
| Tocris | 2073 | (R)-(-)-Apomorphinehydrochloride ≥99%(HPLC) | 314-19-2 | 50 | $107 | 2021-12-16 | Buy |
| TRC | A727548 | (R)-(-)-ApomorphineHydrochloride | 314-19-2 | 1mg | $45 | 2021-12-16 | Buy |
APOMORPHINE HYDROCHLORIDE Chemical Properties,Uses,Production
Originator
Apomorphine hydrochloride,Nastech Pharmaceuticals Company, Inc.
Uses
Emetic.
Uses
(R)-(-)-Apomorphine Hydrochloride is a prototypical dopamine agonist. Potential treatment for Parkinson’s disease.
Manufacturing Process
2 Methods of producing of apomorphine
1. The apomorphine was obtained by dehydratation of morphine at heating to
120°C in the presence phosphoric acid and rendering of HCl gas over reaction
mixture.
2. The morphine was converted to β-chloromorphine and then to
dichlorodihydrodesoxymorphine at heating to 140°-150°C in the presence
hydrochloric acid. Then apomorphine is obtained by dehydratation of
dichlorodihydrodesoxymorphine.
brand name
Apokyn (Vernalis).
Therapeutic Function
Emetic, Expectorant, Hypnotic, Antiparkinsonian, Dopamine agonist
General Description
Apomorphine hydrochloride,(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolone-10,11-diol hydrochloride (Apokyn), is awhite or off-white powder or crystal soluble in hot water(pKa＝8.92). Apormorphine is an aporphine alkaloid of thebenzoquinoline class. Oral apomorphine is poorly absorbedand has a bioavailability of less than 4%. Upon subcutaneousadministration, apomorphine is completely absorbed. Within10 to 20 minutes, the maximum concentration of the drug isdistributed from the blood plasma to the CSF. Other potentialroutes of administration include continuous subcutaneous infusion,intravenous infusion, intranasal spray application,sublingual, and rectal administration.23 The agent is highlylipophilic in nature, allowing for rapid diffusion across theBBB after injection. Apomorphine has a short plasma halflife;however, clinical effects may last from 60 to 90 minutes.Apomorphine displays a significant degree of interpatientvariability in its pharmacokinetic profile. Studies of bothintravenous and subcutaneous injection routes found this variation was not attributable to body weight, age, gender,and duration of PD or L-DOPA dose/duration alone.Apomorphine is extensively metabolized. Hypothesizedroutes include sulfation, N-demethylation, glucuronidation,and oxidation. Subcutaneous injections of apomorphine arerenally and hepatically cleared, with the majority appearingto be renally cleared. Dosage adjustments are needed in bothliver and renal impairment. The activity of apomorphine isbelieved to be caused by stimulation of postsynaptic D1- andD2-type receptors within the caudate/putamen in the brain.Apomorphine is indicated for the acute, intermittent treatmentof hypomobility, “off” episodes (“end-of-dose wearingoff” and unpredictable on/off episodes) associated with advancedPD.
Biological Activity
Prototypical dopamine agonist (pK i values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D 1 , D 2L , D 3 , D 4 and D 5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo .
Clinical Use
Treatment of refractory motor fluctuations in Parkinson’s disease
Safety Profile
Poison by intravenous andintraperitoneal routes. Mutation data reported. When heated to decomposition itemits very toxic fumes of NOx and HCl.
Veterinary Drugs and Treatments
Apomorphine is used primarily as an emetic in dogs, and is considered the emetic of choice for dogs by many clinicians. It is sometimes used in cats, but its use in this species is somewhat controversial.
Drug interactions
Potentially hazardous interactions with other drugs
Antihypertensives: enhanced hypotensive effect.
Domperidone: possible increased risk of ventricular
arrhythmias.
5HT3
-receptor antagonists: possibly increased
hypotensive effects with ondansetron.
Nitrates: enhanced hypotensive effect.
Metabolism
After subcutaneous injection its fate can be described by a two-compartment model, with a distribution half-life of 5 (±1.1) minutes and an elimination half-life of 33 (±3.9) minutes. Clinical response correlates well with levels of apomorphine in the cerebrospinal fluid. Apomorphine is extensively metabolised in the liver, mainly by conjugation with glucuronic acid or sulfate; the major metabolite is apomorphine sulfate. It is also demethylated to produce norapomorphine. Most of a dose is excreted in urine, mainly as metabolites.
storage
Store at RT
APOMORPHINE HYDROCHLORIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3842 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9604 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29525 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973186 4009686088 | 3193328036@qq.com | China | 18352 | 68 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55591 | 58 |
| Shenzhen Botel Biotechnology Co. Ltd. | 0755-22202135 13316968096 | 1979313431@qq.com | China | 7516 | 58 |
View Lastest Price from APOMORPHINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-05-12 | APOMORPHINE HYDROCHLORIDE
314-19-2
|
US $1.10 / g | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2021-08-05 | Apomorphine hydrochloride USP/EP/BP | US $1.10 / g | 1g | 0.999 | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-20 | Apomorphine Hydrochloride
314-19-2
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- APOMORPHINE HYDROCHLORIDE
314-19-2
- US $1.10 / g
- 99.0% Min
- Dideu Industries Group Limited
-
- Apomorphine hydrochloride USP/EP/BP
- US $1.10 / g
- 0.999
- Dideu Industries Group Limited
-
- Apomorphine Hydrochloride
314-19-2
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
314-19-2(APOMORPHINE HYDROCHLORIDE)Related Search:
1of4