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L-Hydroxyproline

L-Hydroxyproline Structure
L-Hydroxyproline structure
CAS No.
51-35-4
Chemical Name:
L-Hydroxyproline
Synonyms
TRANS-4-HYDROXY-L-PROLINE;HYDROXYPROLINE;(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;Hyp;4-Hydroxyproline;4-HYDROXY-L-PROLINE;H-HYP-OH;4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;HYDROXY-L-PROLINE;4R-4-hydroxyproline
CBNumber:
CB8357870
Molecular Formula:
C5H9NO3
Molecular Weight:
131.13
MDL Number:
MFCD00064320
MOL File:
51-35-4.mol
MSDS File:
SDS
Last updated:2025-11-11 10:47:11
Product description Number Pack Size Price
Hydroxyproline Pharmaceutical Secondary Standard; Certified Reference Material PHR1939 500MG $176.7
trans-4-Hydroxy-L-proline ≥99% H54409 2.5g $40.4
trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 56250 5 g $55.1
trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 56250 25 g $108
trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 56250 100 g $169
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L-Hydroxyproline Properties

Melting point 273 °C (dec.)(lit.)
alpha -75.5 º (c=5, H2O)
Boiling point 242.42°C (rough estimate)
Density 1.3121 (rough estimate)
bulk density 610kg/m3
vapor density 4.5 (vs air)
refractive index -75.5 ° (C=4, H2O)
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL
form Crystals or Crystalline Powder
pka 1.82, 9.66(at 25℃)
color White
Odor Odorless
PH 5.5-6.5 (50g/l, H2O, 20℃)
optical activity [α]25/D 75.6°, c = 1 in H2O
Water Solubility 357.8 g/L (20 º C)
Merck 14,4840
BRN 471933
InChIKey PMMYEEVYMWASQN-DMTCNVIQSA-N
LogP -0.350 (est)
CAS DataBase Reference 51-35-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) L-HYDROXYPROLINE
EWG's Food Scores 1
FDA UNII RMB44WO89X
NIST Chemistry Reference Hydroxyproline(51-35-4)
EPA Substance Registry System trans-4-Hydroxy-L-proline (51-35-4)
UNSPSC Code 85151701
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  24/25-36/37/39-27-26
WGK Germany  3
RTECS  TW3586500
TSCA  Yes
HazardClass  IRRITANT
HS Code  29339990
NFPA 704
1
0 0

L-Hydroxyproline price More Price(89)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1939 Hydroxyproline Pharmaceutical Secondary Standard; Certified Reference Material 51-35-4 500MG $176.7 2025-07-31 Buy
Sigma-Aldrich H54409 trans-4-Hydroxy-L-proline ≥99% 51-35-4 2.5g $40.4 2025-07-31 Buy
Sigma-Aldrich 56250 trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 51-35-4 5 g $55.1 2025-07-31 Buy
Sigma-Aldrich 56250 trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 51-35-4 25 g $108 2025-07-31 Buy
Sigma-Aldrich 56250 trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 51-35-4 100 g $169 2025-07-31 Buy
Product number Packaging Price Buy
PHR1939 500MG $176.7 Buy
H54409 2.5g $40.4 Buy
56250 5 g $55.1 Buy
56250 25 g $108 Buy
56250 100 g $169 Buy

L-Hydroxyproline Chemical Properties,Uses,Production

Description

A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.

Chemical Properties

White crystalline powder

Uses

A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Uses

hydroxyproline is a skin-conditioning amino acid. It is a component of collagen.

Uses

A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins.

Production Methods

In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.
Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.

Definition

ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

reaction suitability

reaction type: solution phase peptide synthesis

Biochem/physiol Actions

Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.

Purification Methods

Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]

L-Hydroxyproline synthesis

147-85-3
51-35-4
Synthesis of L-Hydroxyproline from L-Proline

L-Hydroxyproline Preparation Products And Raw materials

Raw materials

Soy bean Isoflavone Isoflavone 10-40% Α-protein Bone glue Casein Gelatin

Preparation Products

N-Boc-cis-4-Hydroxy-L-proline methyl ester (R)-(-)-3-Pyrrolidinol hydrochloride (2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride N-Boc-4-oxo-L-Proline methyl ester
Fmoc-L-hydroxyproline 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester, (2S,4S)- 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- BETONICINE
TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER 1-BENZYLPYRROLE 1-PHENYLPYRROLE

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L-Hydroxyproline Suppliers

Global( 1096)Suppliers
Supplier Tel Email Country ProdList Advantage
BTC pharm India
+918790379245 banny.janga@btcpharm.com India 1262 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8770 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3587 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5250 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Hebei Saisier Technology Co., LTD 		+86-18400010335 +86-18034520335 admin@hbsaisier.cn China 1015 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Hebei Longbang Technology Co., LTD 		+86-18633929156 admin@hblongbang.com China 972 58
Shandong Deshang Chemical Co., Ltd. 		+86-0531-8875-2665 +8613153039501 info@deshangchem.com China 661 58
Supplier Advantage
BTC pharm India
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Hebei Saisier Technology Co., LTD 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Hebei Longbang Technology Co., LTD 		58
Shandong Deshang Chemical Co., Ltd. 		58

Related articles

View Lastest Price from L-Hydroxyproline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Hydroxyproline pictures 2025-11-17 L-Hydroxyproline
51-35-4
 0.99 RongNa Biotechnology Co.,Ltd
L-Hydroxyproline pictures 2025-11-17 L-Hydroxyproline
51-35-4
 US $0.00 / Kg/Drum 1KG 98.5%-101.0%; AJI92 10 TONS WUHAN FORTUNA CHEMICAL CO., LTD
L-Hydroxyproline pictures 2025-11-14 L-Hydroxyproline
51-35-4
 US $10.00 / KG 1KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
  • L-Hydroxyproline pictures
  • L-Hydroxyproline
    51-35-4
  • US $0.00 / Kg/Drum
  • 98.5%-101.0%; AJI92
  • WUHAN FORTUNA CHEMICAL CO., LTD

L-Hydroxyproline Spectrum

L-Hydroxyproline(51-35-4)MSL-Hydroxyproline(51-35-4)1HNMRL-Hydroxyproline(51-35-4)13CNMRL-Hydroxyproline(51-35-4)IR1L-Hydroxyproline(51-35-4)IR2L-Hydroxyproline(51-35-4)Raman

51-35-4(L-Hydroxyproline)Related Search:

trans,trans-2,4-Undecadienal trans-4-Hydroxy-D-proline D-Proline trans-4-Hydroxy-L-proline methyl ester hydrochloride CHLOROPHOSPHONAZO III
L-Proline N-Acetyl-L-Hydroxyproline L-PROLINE-(4-3H(N)) L-(+)-Prolinol L-Leucine
Methyl L-leucinate hydrochloride cis-4-Hydroxy-L-proline Boc-Hyp-OH cis-4-Hydroxy-D-proline BETONICINE
(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER BOC-HYP(BZL)-OH Fmoc-Hyp(tBu)-OH

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(S)-(-)-TRANS-4-HYDROXYPROLINE FOR SYNTH trans-4-Hydroxy-L-proline, 99+% 10GR trans-4-Hydroxy-L-proline, 99+% 25GR trans-4-Hydroxy-L-proline Microbial, cell culture tested 4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID 4-HYDROXY-L-PROLINE TRANS ISOMER (S)-(-)-TRANS-4-HYDROXYPROLINE RARECHEM EM WB 0135 TRANS-L-HYDROXYPROLINE TRANS-L-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 4-L-Hydroxyproline delta-Hydroxyproline L-Proline, 4-hydroxy-, trans- L-Proline,4-hydroxy-,trans Ls-Hydroxyproline Proline, 4-hydroxy- Proline, 4-hydroxy-, L- trans-Hydroxyproline (-)-(2S,4R)-4-Hydroxyproline L-Hypro (4R)-4-Hydroxy-L-proline (4R)-4β-Hydroxy-L-proline 2-Hydroxy-L-proline 2-Hydroxyproline L-Hydroxyproline 〔trans-4-Hydroxy-L-proline〕 L-Hydroxyproline 〔trans-4-Hydroxy-L-proline〕, Animal-Free trans-L-4-Hydroxyproline≥ 99% (Titration) trans-L-4-HydroxyprolineNon-animal Japanese origin99.0-101.0% (Assay, dry basis) trans-4-Hydroxy-L-proline,99%e.e. TRANS-4-HYDROXY-L-PROLINE BIOXTRA, > (S)-(-)-trans-4-Hydroxyproline for synthesis [2S,4S]-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID (2S,4R)-(-)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID (2S,4R)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID H-HYP-OH (TRANS) H-L-HYDROXYPROLINE H-L-HYP-OH H-TRANS-HYP-OH HYDROXY-L-PROLINE, TRANS-4- HYDROXYPROLINE, L- L-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID L-4-TRANS-HYDROXYPROLINE L-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID L-4-HYDROXY-2-PYRROLIDINE-CARBOXYLIC ACID TRANS-ISOMER L4-4-HYDROXY-2-PYRROLIDINE-CARBOXYLIC ACID TRANS ISOMER L-TRANS-4-HYDROXYPROLINE L-HYDROXYPROLINE (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acidHyp 4-hydroxy-L-proline (trans) TRANS-4-HYDROXY-L-PROLINE, 99+% L-HydroxyprolineForBiochemistry L-Hydroxyproline99+% L-HYDROXYPROLINE ( AKA ) TRANS 4 HYDROXY L PROLINE TRANS 4 HYDROXY L PROLINE (HYPRO) TRANS-L-HYDROXYPROLINE, (2S,4R)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID L-HYDROXY PROLINE/TRANS-L-4-HYDROXYPROLINE L-HYDROXYPROLINE51-35-4 HYDROXY-L-PROLINE, trans-4-(RG)