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L-Hydroxyproline

L-Hydroxyproline
L-Hydroxyproline structure
CAS No.
51-35-4
Chemical Name:
L-Hydroxyproline
Synonyms
5kg;Hyp;HPDR;PHEX;Hypro;HPDR1;L-HYP;OH-pro;L-Hypro;L-Hyp-OH
CBNumber:
CB8357870
Molecular Formula:
C5H9NO3
Formula Weight:
131.13
MOL File:
51-35-4.mol

L-Hydroxyproline Properties

Melting point:
273 °C (dec.)(lit.)
alpha 
-75.5 º (c=5, H2O)
Boiling point:
242.42°C (rough estimate)
Density 
1.3121 (rough estimate)
vapor density 
4.5 (vs air)
refractive index 
-75.5 ° (C=4, H2O)
storage temp. 
Store at RT.
solubility 
H2O: 50 mg/mL
pka
1.82, 9.66(at 25℃)
form 
Crystals or Crystalline Powder
color 
White
PH
5.5-6.5 (50g/l, H2O, 20℃)
Odor
Odorless
optical activity
[α]25/D 75.6°, c = 1 in H2O
Water Solubility 
357.8 g/L (20 º C)
Merck 
14,4840
BRN 
471933
InChIKey
PMMYEEVYMWASQN-DMTCNVIQSA-N
CAS DataBase Reference
51-35-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
L-HYDROXYPROLINE
EWG's Food Scores
1
FDA UNII
RMB44WO89X
NIST Chemistry Reference
Hydroxyproline(51-35-4)
EPA Substance Registry System
trans-4-Hydroxy-L-proline (51-35-4)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  24/25-36/37/39-27-26
WGK Germany  3
RTECS  TW3586500
Hazard Note  Irritant
TSCA  Yes
HazardClass  IRRITANT
HS Code  29339990

L-Hydroxyproline price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H54409 trans-4-Hydroxy-L-proline ≥99% 51-35-4 2.5g $20 2019-12-02 Buy
Sigma-Aldrich 41875 trans-4-Hydroxy-L-proline analytical standard 51-35-4 100mg $52.6 2019-12-02 Buy
TCI Chemical H0296 trans-4-Hydroxy-L-proline >99.0%(HPLC)(T) 51-35-4 5g $23 2020-06-24 Buy
TCI Chemical H0296 trans-4-Hydroxy-L-proline >99.0%(HPLC)(T) 51-35-4 25g $60 2020-06-24 Buy
Alfa Aesar A11851 trans-4-Hydroxy-L-proline, 99+% 51-35-4 25g $67.7 2020-06-24 Buy

L-Hydroxyproline Chemical Properties,Uses,Production

Description

A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.

Chemical Properties

White crystalline powder

Uses

A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Uses

A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins.

Uses

hydroxyproline is a skin-conditioning amino acid. It is a component of collagen.

Production Methods

In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.
Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.

Definition

ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.

Purification Methods

Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]

L-Hydroxyproline Preparation Products And Raw materials

Raw materials

Preparation Products


L-Hydroxyproline Suppliers

Global( 584)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Huaian yishu technology co.,ltd
86-0517-85883738
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0523-86201489 sales@thbiochem.com CHINA 306 60
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+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
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86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2678 55

View Lastest Price from L-Hydroxyproline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-05-13 trans-4-Hydroxy-L-proline
US $10.00 / g 100g 99.5% 200kg Hebei Aicrowe Biotech Co., Ltd
2020-04-23 L-Hydroxyproline
51-35-4
US $0.00 / mg 20mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2018-10-25 High purity trans-4-Hydroxy-L-proline 51-35-4 CAS NO.51-35-4
51-35-4
US $1.00 / G 100G 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd

L-Hydroxyproline Spectrum


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