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6-Nitroindazole

6-Nitroindazole Structure
6-Nitroindazole structure
CAS No.
7597-18-4
Chemical Name:
6-Nitroindazole
Synonyms
6-NITRO-1H-INDAZOLE;6-Nitrobrazol;6-NITROINDAZOLE;6-Nitroindazoles;6-Nitroisoindazole;6-nitro-1h-indazol;6-Nitroindazole>6-Nitroindazole 97%;6-Nitroindazole,98%;6-Nitroindazole ,97%
CBNumber:
CB8358413
Molecular Formula:
C7H5N3O2
Molecular Weight:
163.13
MDL Number:
MFCD00005695
MOL File:
7597-18-4.mol
MSDS File:
SDS
Last updated:2023-12-27 16:49:21
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6-Nitroindazole Properties

Melting point 180-182 °C (lit.)
Boiling point 290.19°C (rough estimate)
Density 1.4141 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility very faint turbidity in hot Methanol
form Powder
pka 11.08±0.40(Predicted)
color Light Yellow
BRN 7812
CAS DataBase Reference 7597-18-4(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference 6-Nitroindazole(7597-18-4)
EPA Substance Registry System 1H-Indazole, 6-nitro- (7597-18-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H351
Precautionary statements  P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-40-68-36
Safety Statements  26-27-36/37/39
WGK Germany  3
RTECS  NK7962100
TSCA  Yes
HS Code  29339900
NFPA 704
0
1 0

6-Nitroindazole price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N17513 6-Nitroindazole 97% 7597-18-4 100g $254 2023-06-20 Buy
TCI Chemical N0399 6-Nitroindazole >98.0%(GC) 7597-18-4 25g $34 2024-03-01 Buy
TCI Chemical N0399 6-Nitroindazole >98.0%(GC) 7597-18-4 250g $167 2024-03-01 Buy
Alfa Aesar A16213 6-Nitro-1H-indazole, 97% 7597-18-4 100g $88 2021-12-16 Buy
Alfa Aesar A16213 6-Nitro-1H-indazole, 97% 7597-18-4 25g $35.8 2021-12-16 Buy
Product number Packaging Price Buy
N17513 100g $254 Buy
N0399 25g $34 Buy
N0399 250g $167 Buy
A16213 100g $88 Buy
A16213 25g $35.8 Buy

6-Nitroindazole Chemical Properties,Uses,Production

Description

6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].

Chemical Properties

yellow powder

Uses

Anticonvulsant.

Synthesis

6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated  acetonitrile.6-Nitroindazole

References

[1] HERRAIZTOMAS  GuillénHugo  AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170.

6-Nitroindazole synthesis

99-55-8
7597-18-4
Synthesis of 6-Nitroindazole from 2-Methyl-5-nitroaniline

6-Nitroindazole Preparation Products And Raw materials

Raw materials

Sodium nitrite 2-Methyl-5-nitroaniline Acetic acid

Preparation Products

6-Iodo-1H-indazole 6-AMINO-2-METHYL-2H-INDAZOLE (E)-6-Nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine 1-METHYL-1H-INDAZOL-6-YLAMINE
2-Methyl-5-nitrophenol 3-Iodo-6-nitroindazole 6-Hydroxyindazole 5,6-dinitro-1H-indazole tert-butyl 6-nitro-1H-indazole-1-carboxylate
6-Nitro-1H-indazol-7-aMine 6-Aminoindazole

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6-Nitroindazole Suppliers

Global( 314)Suppliers
Supplier Tel Email Country ProdList Advantage
Zison Pharmaceutical (Shandong) Co., Ltd.
+86-0086-531-88259693 +86-18660188356 maguanglei@zisonpharm.com China 53 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +86-15064153060 alice@jndxj.com China 309 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Supplier Advantage
Zison Pharmaceutical (Shandong) Co., Ltd.
58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58
career henan chemical co 		58
Anhui Dexinjia Biopharm Co., Ltd 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Accela ChemBio Inc. 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from 6-Nitroindazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Nitroindazole pictures 2024-04-26 6-Nitroindazole
7597-18-4
 US $100.00-2000.00 / kg 0.10000000149011612kg 98% 2MT per month Anhui Dexinjia Biopharm Co., Ltd
6-Nitroindazole pictures 2023-12-27 6-Nitroindazole
7597-18-4
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
6-Nitro-1H-indazole pictures 2023-12-01 6-Nitro-1H-indazole
7597-18-4
 US $0.00-0.00 / kg 1kg ≥98% by HPLC 100kg/month Zison Pharmaceutical (Shandong) Co., Ltd.
  • 6-Nitroindazole pictures
  • 6-Nitroindazole
    7597-18-4
  • US $100.00-2000.00 / kg
  • 98%
  • Anhui Dexinjia Biopharm Co., Ltd
  • 6-Nitroindazole pictures
  • 6-Nitroindazole
    7597-18-4
  • US $0.00-0.00 / kg
  • 98%
  • Nanjing Fred Technology Co., Ltd
  • 6-Nitro-1H-indazole pictures
  • 6-Nitro-1H-indazole
    7597-18-4
  • US $0.00-0.00 / kg
  • ≥98% by HPLC
  • Zison Pharmaceutical (Shandong) Co., Ltd.

6-Nitroindazole Spectrum

6-Nitroindazole(7597-18-4)1HNMR6-Nitroindazole(7597-18-4)13CNMR6-Nitroindazole(7597-18-4)IR16-Nitroindazole(7597-18-4)Raman

7597-18-4(6-Nitroindazole)Related Search:

3-Methyl-6-nitroindazole 3-Nitroacetophenone Sodium 3-nitrobenzenesulphonate 2-Ethyl-5-nitrobenzenamine ,98% 5-Amino-2-methylbenzenesulfonamide
N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine Pazopanib Impurity 48 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32
2,4-Dichloropyrimidine Benzenamine, 2-ethyl-4-nitro- 3-AMINO-4-METHYLBENZENESULFONAMIDE 2-amino-5-methylbenzenesulfonamide Pazopanib-d6
2H-Indazol-4-amine, 2,3-dimethyl- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- Pazopanib Impurity 47

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1H-Indazole, 6-nitro- 6-nitro-1h-indazol 6-Nitroisoindazole 6-NITROINDAZOLE 6-Nitro-1(2)H-indazole 6-Nitroindazole ,97% 6-Nitroindazole,98% 6-Nitroindazoles 6-Nitro-1H-indazole,97% 6-Nitroindazole 97% 6-Nitroindazole> 6-Nitrobrazol Pazopanib Impurity 59 6-NITRO-1H-INDAZOLE 7597-18-4 9597-18-4 Building Blocks Heterocyclic Building Blocks Indazoles Inhibitors Nitric Oxide Reagents Building Blocks Heterocyclic Building Blocks Heterocyclic Compounds All Inhibitors Indazoles Intermediate