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4-Hydroxy-D-(-)-2-phenylglycine

4-Hydroxy-D-(-)-2-phenylglycine structure

CAS No.: 22818-40-2

Chemical Name:: 4-Hydroxy-D-(-)-2-phenylglycine

Synonyms: (R)-2-AMino-2-(4-hydroxyphenyl)acetic acid;D-4-HYDROXYPHENYLGLYCINE;(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid;H-D-PHG(4-OH)-OH;AMoxicillin EP IMpurity I;AMoxicillin Related CoMpound I;Cefadroxil impurity A;4-HYDROXY-D-PHENYLGLYCINE;D-α-(4-hydroxyphenyl)glycine;(R)-(-)-2-Phenylglycine amide

CBNumber:: CB8372699

Molecular Formula:: C8H9NO3

Molecular Weight:: 167.16

MDL Number:: MFCD00004262

MOL File:: 22818-40-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-19 07:28:27

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4-Hydroxy-D-(-)-2-phenylglycine Properties

Melting point	240 °C (dec.)(lit.)
alpha	-156 º (c=1, 1 N HCl)
Boiling point	295.73°C (rough estimate)
Density	1.396
vapor pressure	0Pa at 25℃
refractive index	-158 ° (C=1, 1mol/L HCl)
storage temp.	2-8°C
solubility	5g/l
pka	2.15±0.10(Predicted)
form	Liquid
color	Clear colorless to yellow
optical activity	[α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility	5 g/L (20 ºC)
BRN	2210998
Major Application	peptide synthesis
InChI	1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m1/s1
InChIKey	LJCWONGJFPCTTL-SSDOTTSWSA-N
SMILES	N[C@@H](C(O)=O)c1ccc(O)cc1
LogP	-2.25
CAS DataBase Reference	22818-40-2(CAS DataBase Reference)
FDA UNII	PCM9OIX717
EPA Substance Registry System	Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

TSCA

TSCA listed

HS Code

29225000

Storage Class

13 - Non Combustible Solids

REACH Registrations

Active

NFPA 704

	0
2		0

4-Hydroxy-D-(-)-2-phenylglycine price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001372	Cefprozil impurity A European Pharmacopoeia (EP) Reference Standard	22818-40-2	25 mg	$127	2026-04-30	Buy
Sigma-Aldrich	PHR2196	Amoxicillin Related Compound I	22818-40-2	50MG	$539	2026-04-30	Buy
Sigma-Aldrich	H1430000	D-α-(4-Hydroxy-phenyl)glycine European Pharmacopoeia (EP) Reference Standard	22818-40-2	25 mg	$164	2026-04-30	Buy
Sigma-Aldrich	1031591	Amoxicillin Related Compound I United States Pharmacopeia (USP) Reference Standard	22818-40-2	25mg	$1390	2026-04-30	Buy
Sigma-Aldrich	215333	4-Hydroxy-D-phenylglycine ≥98%	22818-40-2	25g	$50.1	2023-06-20	Buy

Product number	Packaging	Price	Buy
Y0001372	25 mg	$127	Buy
PHR2196	50MG	$539	Buy
H1430000	25 mg	$164	Buy
1031591	25mg	$1390	Buy
215333	25g	$50.1	Buy

4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties, Uses, Production

Description

d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.

Chemical Properties

off-white powder

Uses

4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Uses

4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Definition

ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.

Flammability and Explosibility

Non flammable

reaction suitability

reaction type: solution phase peptide synthesis

Purification Methods

Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

4-Hydroxy-D-(-)-2-phenylglycine Preparation Products And Raw materials

Raw materials

DL-P-Hydroxyphenylglycine Glyoxal Phenol DL-Tartaric acid D(-)-Tartaric acid

p-Anisaldehyde Glyoxylic acid

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Preparation Products

D-(-)-A-4-Hydroxyphenylglycine dane salt methyl potassium (2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid (R)-3-Bromo-4-hydroxyphenylglycine Fmoc-D-4-Hydroxyphenylglycine (R)-Amino-4-hydroxy-cyclohexaneacetic acid

4-Hydroxy-D-(-)-2-phenylglycine Suppliers

Global Suppliers ( 568)

Supplier	Tel	Email	Country	ProdList	Advantage
Chemtour Biotech Co., Ltd		market@chemtour.com	China	1517	58
Shanghai Chang-Gen Chemical Technology Co., Ltd.	021-69106814 13917161715	3007500651@qq.com	China	80	60
Shandong Kanghong New Material Technology Co., Ltd	17686625089; 17686625089	shandongkanghong@qq.com	China	102	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Chemtour Biotech Co., Ltd	58
Shanghai Chang-Gen Chemical Technology Co., Ltd.	60
Shandong Kanghong New Material Technology Co., Ltd	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from 4-Hydroxy-D-(-)-2-phenylglycine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	D(-)-4-Hydroxyphenylglycine 22818-40-2		1kg	99		Hangzhou Lucky Biology Co., Ltd
2026-08-21	4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2	$60.00-72.00	10kilograms	99%	100tons	Hebei Dangtong Import and export Co LTD
2026-06-30	4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

D(-)-4-Hydroxyphenylglycine
22818-40-2
$0.00
99
Hangzhou Lucky Biology Co., Ltd

4-Hydroxy-D-(-)-2-phenylglycine
22818-40-2
$60.00-72.00
99%
Hebei Dangtong Import and export Co LTD

4-Hydroxy-D-(-)-2-phenylglycine
22818-40-2
98%
Shaanxi Dideu New Materials Co. Ltd

4-Hydroxy-D-(-)-2-phenylglycine Spectrum

4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)MS 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)¹HNMR 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)IR1 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)IR2 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)Raman

22818-40-2 (4-Hydroxy-D-(-)-2-phenylglycine) Related Search:

D-2-Phenylglycine Methylparaben Betaine 4-Hydroxyphenylacetic acid 4-Hydroxybenzoic acid

4-Aminophenylacetic acid Anilinoacetic acid 4-Hydroxybenzaldehyde L-Phenylglycine 6-Aminocaproic acid

D-4-Hydroxyphenylglycine methyl ester D(+)-Trehalose dihydrate D(+)-Malic acid Glycine α-Lipoic Acid

Chlorophosphonazo III D-(-)-A-4-Hydroxyphenylglycine dane salt methyl potassium (S)-Amlodipine

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(R)-4-HYDROXYPHENYLGLYCINE (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE D-(-)-2-(4-HYDROXYPHENYL)GLYCINE D(-)-2-(P-HYDROXYPHENYL)GLYCINE D-(-)-A-4-HYDROXYPHENYLGLYCINE D-4-HYDROXYPHENYLGLICYNE D-(-)-4-HYDROXYPHENYLGLYCINE D-ALPHA-PARA-HYDROXYPHENYLGLYCINE (D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE D-(-)-P-HYDROXYPHENYLGLYCINE D-P-HYDROXYPHENYLGLYCINE D(-)PARA-HYDROXY-PHENYLGLYCINE HYDROXY PHENYL GLYCINE H-D-HPG-OH H-D-PHG(4-HYDROXY)-OH (theta)-benzeneaceticaci .alpha.-amino-4-hydroxy-,(R)-Benzeneaceticacid a-Amino-p-hydroxyphenylaceticacid Benzeneaceticacid,alpha.-amino-4-hydroxy-,(R)- Benzeneaceticacid,-amino-4-hydroxy-,(R)- L-(-)-4-Hydroxy-α-aminophenylacetic acid D(-)-P-Hydroxyphenylglycine, 98+% (2R)-2-(4-Hydroxyphenyl)glycine (R)-2-(p-Hydroxyphenyl)glycine p-Hydroxy-D-phenylglycine α-(4-Hydroxyphenyl)-D-glycine (2R)-2-Amino-2-(4-hydroxyphenyl)ethanoic acid, (R)-Amino(4-hydroxyphenyl)acetic acid Amoxicillin Related Compound I (15 mg) ((R)-2-Amino-2-(4-hydroxyphenyl)acetic acid) D(-)-4-Hydroxyphenylglycine, 98+% 100GR D(-)-4-Hydroxyphenylglycine, 98+% 25GR D(-)-4-Hydroxyphenylglycine ,99% D(-)-alpha-para-Hydroxyphenylglycine base (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic Acid 4-Hydroxy-D-phenylglycine Benzeneacetic acid, a-aMino-4-hydroxy-, (aR)- 4-Hydroxy-D-(-)-2-phenylglycine (-)-4-Hydroxy-D-phenylglycine, 98+% D-(-)p-hydroxyphenylgcine Dane salt 4-Hydroxy-D-(-)-2-phenylglycine, 99.0%(LC&T D(-)-4-Hydroxyphenylglycine 4-Hydroxy-D-phenylglycine Cefprozil impurity A Cefadroxyl impurity A D-N-(4-hydroxyphenyl)glycine Parahydroxy phenylglycine base D-a-(-)-parahydroxyphenylgycine (2R)-2-amino-(4-Hydroxyphenyl)acetic acid D-4-HYDROXYPHENYLGLYCINE, 98+% d-p-hydroxyglycine (2R)-amino(4-hydroxyphenyl)acetic acid 2-(4-Hydroxy-phenyl)glycin D-Form D-(-)-p-Hydroxy Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (r)-(-)-à-amino-(4-hydroxyphenyl)acetic acid D(-)-P-HYDROXYPHENYLGLYCINE BASE (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE 99+% (R)-(4-HYDROXYPHENYL)GLYCINE (4-HYDROXY-D-PHENYLGLYCINE) D-(-)-4-HYDROXYPHENYLGLYCINE, NA OR K SALT PARA-HYDROXYPHENYLGLYCINE D-4-OH-Phg-OH