ChemicalBook >> CAS DataBase List >>4-Hydroxy-D-(-)-2-phenylglycine


Chemical Name:
(R)-2-AMino-2-(4-hydroxyphenyl)acetic acid;H-D-PHG(4-OH)-OH;D-4-HYDROXYPHENYLGLYCINE;4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-2-Phenylglycine amide;AMoxicillin Related CoMpound I;(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid;B8372699;H-D-HPG-OH;D-4-OH-Phg-OH
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2024-05-01 11:53:09

4-Hydroxy-D-(-)-2-phenylglycine Properties

Melting point 240 °C (dec.)(lit.)
Boiling point 295.73°C (rough estimate)
alpha -156 º (c=1, 1 N HCl)
Density 1.396
vapor pressure 0Pa at 25℃
refractive index -158 ° (C=1, 1mol/L HCl)
storage temp. 2-8°C
solubility 5g/l
form Liquid
pka 2.15±0.10(Predicted)
color Clear colorless to yellow
optical activity [α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility 5 g/L (20 ºC)
BRN 2210998
LogP -2.25
CAS DataBase Reference 22818-40-2(CAS DataBase Reference)
EPA Substance Registry System Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
HS Code  29225000
NFPA 704
2 0

4-Hydroxy-D-(-)-2-phenylglycine price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2196 Amoxicillin Related Compound I 22818-40-2 50MG $485 2024-03-01 Buy
Sigma-Aldrich 215333 4-Hydroxy-D-phenylglycine ≥98% 22818-40-2 25g $50.1 2023-06-20 Buy
Sigma-Aldrich 1031591 Amoxicillin Related Compound I United States Pharmacopeia (USP) Reference Standard 22818-40-2 25mg $1310 2022-05-15 Buy
TCI Chemical H0758 4-Hydroxy-D-(-)-2-phenylglycine >99.0%(HPLC)(T) 22818-40-2 25g $40 2024-03-01 Buy
TCI Chemical H0758 4-Hydroxy-D-(-)-2-phenylglycine >99.0%(HPLC)(T) 22818-40-2 100g $77 2024-03-01 Buy
Product number Packaging Price Buy
PHR2196 50MG $485 Buy
215333 25g $50.1 Buy
1031591 25mg $1310 Buy
H0758 25g $40 Buy
H0758 100g $77 Buy

4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties,Uses,Production


d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.

Chemical Properties

off-white powder


4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.


4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.


ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

Global( 522)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 China 12470 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 China 2503 58
Apeloa production Co.,Limited
+86-19131931000 +86-19131931000 China 246 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106 China 885 50
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 China 15956 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21689 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 China 2989 55
career henan chemical co
+86-0371-86658258 China 29914 58
Accela ChemBio Inc.
(+1)-858-699-3322 United States 19965 58

View Lastest Price from 4-Hydroxy-D-(-)-2-phenylglycine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D(-)-4-Hydroxyphenylglycine pictures 2024-05-24 D(-)-4-Hydroxyphenylglycine
US $1.00 / g 1g 98% 1000 Apeloa production Co.,Limited
4-Hydroxy-D-(-)-2-phenylglycine pictures 2024-05-24 4-Hydroxy-D-(-)-2-phenylglycine
US $72.00-60.00 / kilograms 10kilograms 99% 100tons Hebei Dangtong Import and export Co LTD
4-Hydroxy-D-(-)-2-phenylglycine pictures 2024-04-24 4-Hydroxy-D-(-)-2-phenylglycine
US $10.00 / kg 1kg 99.8% 10000ton Ouhuang Engineering Materials (Hubei) Co., Ltd
(R)-4-HYDROXYPHENYLGLYCINE (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE D-(-)-2-(4-HYDROXYPHENYL)GLYCINE D(-)-2-(P-HYDROXYPHENYL)GLYCINE D-(-)-A-4-HYDROXYPHENYLGLYCINE D-4-HYDROXYPHENYLGLICYNE D-(-)-4-HYDROXYPHENYLGLYCINE D-ALPHA-PARA-HYDROXYPHENYLGLYCINE (D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE D-(-)-P-HYDROXYPHENYLGLYCINE D-P-HYDROXYPHENYLGLYCINE D(-)PARA-HYDROXY-PHENYLGLYCINE HYDROXY PHENYL GLYCINE H-D-HPG-OH H-D-PHG(4-HYDROXY)-OH (theta)-benzeneaceticaci .alpha.-amino-4-hydroxy-,(R)-Benzeneaceticacid a-Amino-p-hydroxyphenylaceticacid Benzeneaceticacid,alpha.-amino-4-hydroxy-,(R)- Benzeneaceticacid,-amino-4-hydroxy-,(R)- L-(-)-4-Hydroxy-α-aminophenylacetic acid D(-)-P-Hydroxyphenylglycine, 98+% (2R)-2-(4-Hydroxyphenyl)glycine (R)-2-(p-Hydroxyphenyl)glycine p-Hydroxy-D-phenylglycine α-(4-Hydroxyphenyl)-D-glycine (2R)-2-Amino-2-(4-hydroxyphenyl)ethanoic acid, (R)-Amino(4-hydroxyphenyl)acetic acid Amoxicillin Related Compound I (15 mg) ((R)-2-Amino-2-(4-hydroxyphenyl)acetic acid) D(-)-4-Hydroxyphenylglycine, 98+% 100GR D(-)-4-Hydroxyphenylglycine, 98+% 25GR D(-)-4-Hydroxyphenylglycine ,99% D(-)-alpha-para-Hydroxyphenylglycine base (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic Acid 4-Hydroxy-D-phenylglycine Benzeneacetic acid, a-aMino-4-hydroxy-, (aR)- 4-Hydroxy-D-(-)-2-phenylglycine AMoxicillin EP IMpurity I (-)-4-Hydroxy-D-phenylglycine, 98+% D-(-)p-hydroxyphenylgcine Dane salt 4-Hydroxy-D-(-)-2-phenylglycine, 99.0%(LC&T D(-)-4-Hydroxyphenylglycine 4-Hydroxy-D-phenylglycine Cefprozil impurity A Cefadroxyl impurity A D-N-(4-hydroxyphenyl)glycine Parahydroxy phenylglycine base D-a-(-)-parahydroxyphenylgycine (2R)-2-amino-(4-Hydroxyphenyl)acetic acid D-4-HYDROXYPHENYLGLYCINE, 98+% d-p-hydroxyglycine (2R)-amino(4-hydroxyphenyl)acetic acid 2-(4-Hydroxy-phenyl)glycin D-Form D-(-)-p-Hydroxy Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (r)-(-)-à-amino-(4-hydroxyphenyl)acetic acid D(-)-P-HYDROXYPHENYLGLYCINE BASE (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE 99+% (R)-(4-HYDROXYPHENYL)GLYCINE (4-HYDROXY-D-PHENYLGLYCINE) D-(-)-4-HYDROXYPHENYLGLYCINE, NA OR K SALT PARA-HYDROXYPHENYLGLYCINE