DFMO
- CAS No.
- 70052-12-9
- Chemical Name:
- DFMO
- Synonyms
- DIFLUOROMETHYLORNITHINE;DFMO;RFI 71782;Ccris 3295;Brn 2250529;EFLORNITINE;DL-EFLORNITHINE;H-DL-(F2ME)ORN-OH;α-Difluoromethylornitine;α-difluoromethylornithine
- CBNumber:
- CB8373227
- Molecular Formula:
- C6H12F2N2O2
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00221766
- MOL File:
- 70052-12-9.mol
- MSDS File:
- SDS
| Melting point | 138 °C |
|---|---|
| Boiling point | 347.0±42.0 °C(Predicted) |
| Density | 1.1800 (estimate) |
| storage temp. | Store at 0°C |
| solubility | H2O: >10 mg/mL, soluble |
| pka | 1.22±0.44(Predicted) |
| form | solid |
| color | white |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | DFMO |
| FDA UNII | ZQN1G5V6SR |
DFMO price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D193 | DL-α-Difluoromethylornithine hydrochloride hydrate solid, ≥97% (NMR) | 70052-12-9 | 25mg | $241 | 2024-03-01 | Buy |
| Sigma-Aldrich | D193 | DL-α-Difluoromethylornithine hydrochloride hydrate solid, ≥97% (NMR) | 70052-12-9 | 100mg | $724 | 2024-03-01 | Buy |
| Tocris | 2761 | DFMO | 70052-12-9 | 50 | $324 | 2021-12-16 | Buy |
| Tocris | 2761 | DFMO | 70052-12-9 | 10 | $75 | 2021-12-16 | Buy |
| Usbiological | 255132 | DFMO | 70052-12-9 | 10mg | $310 | 2021-12-16 | Buy |
DFMO Chemical Properties,Uses,Production
Chemical Properties
Off-white powder
Uses
DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.
Definition
ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine.
General Description
Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.
Biological Activity
Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.
Biochem/physiol Actions
Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.
DFMO Preparation Products And Raw materials
Raw materials
Preparation Products
DFMO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9571 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |