PICEATANNOL | 10083-24-6

PICEATANNOL Properties

Melting point	223.0-227.0 °C
Boiling point	108°C/0.04mmHg(lit.)
Density	1.1245 (rough estimate)
refractive index	1.5190 (estimate)
storage temp.	2-8°C
solubility	H₂O: 0.5 mg/mL
form	powder
pka	9.17±0.10(Predicted)
color	light tan to yellow
λmax	323nm(MeOH)(lit.)
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
LogP	2.690 (est)
FDA UNII	6KS3LS0D4F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332
Precautionary statements	P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
Safety Statements	24/25
WGK Germany	3
HS Code	29072990

PICEATANNOL price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P0453	Piceatannol powder	10083-24-6	5mg	$216	2024-03-01	Buy
Sigma-Aldrich	527948	Piceatannol	10083-24-6	1mg	$71.1	2024-03-01	Buy
TCI Chemical	P1928	Piceatannol >98.0%(HPLC)	10083-24-6	100mg	$245	2024-03-01	Buy
TCI Chemical	P1928	Piceatannol >98.0%(HPLC)	10083-24-6	1g	$1457	2024-03-01	Buy
Cayman Chemical	10009366	Piceatannol >98%	10083-24-6	5mg	$48	2024-03-01	Buy

Product number	Packaging	Price	Buy
P0453	5mg	$216	Buy
527948	1mg	$71.1	Buy
P1928	100mg	$245	Buy
P1928	1g	$1457	Buy
10009366	5mg	$48	Buy

PICEATANNOL Chemical Properties,Uses,Production

Description

Piceatannol is a chemical compound with similar structure to resveratrol, being widely existed in vegetables such as grapes, blueberries and passion fruit. It is capable of inhibiting the growth of immature adipocytes, so as to achieve the purpose of weight loss. In addition, it also helps prevent cancer, heart disease and neurological diseases.
In early April 2012, researchers in Purdue University has published a new study in 《Biochemistry》journal, finding that piceatannol can delay the production of new fat cells, and inhibit the growth of immature fat cells into mature cells, which can help control the obesity. The researchers also claim that while this study shows that red wine helps to lose weight, further research is needed to improve the stability and solubility of the white fat to maximize its effect.
Laboratory preparation: 3, 4-dimethoxybenzyl alcohol is used as the starting material; to obtain the target product; the raw material needs to undergo bromination, Arbuzov rearrangement reaction, Wittig-Horner reaction and demethylation reaction.

Application

Antioxidants, having anti-inflammatory, anti-thrombotic, anti-cancer, anti-cancer, anti-hyperlipidemia, anti-bacterial activities.

Description

Piceatannol (10083-24-6) is a naturally occurring analog of resveratrol (Cat.# 10-1057). Inhibits nonreceptor kinases Syk and Lyk (IC50 approximately 10 μM).1 Piceatannol stimulates Sirt1.2

Chemical Properties

yellow to golden or green crystalline powder

Uses

Piceatannol has been used:

to study its effect on Ataxia-Telangiectasia Mutated (ATM) protein kinase
as an inhibitor of ZAP-70 (ζ-chain-associated protein kinase 70)
as an inhibitor of MRP1-mediated 2′,7′-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) transport in intact human erythrocytes and inside-out erythrocyte vesicles (IOVs)

Uses

A human metabolite of Resveratrol (R150000). Piceatannol is strong anti-oxidant.

Definition

ChEBI: A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.

General Description

A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC₅₀ = 3 μM), PKC (IC₅₀ = 8 μM), MLCK (IC₅₀ = 12 μM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca²⁺-dependent protein kinase (CDPK) (IC₅₀ = 19 μM), and p72^syk (IC₅₀ = 10 μM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.

Biological Activity

Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56 lck and syk protein tyrosine kinases and inhibits TNF-induced NF- κ B activation and gene expression. Synthesis results from conversion of resveratrol (5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol ) by cytochrome P450 1B1.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

References

1) Seow et al. (2002), Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro; Eur. J. Pharmacol., 443 189 2) Howitz et al. (2003), Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan; Nature, 425 191

PICEATANNOL synthesis

Synthesis of PICEATANNOL from Resveratrol

PICEATANNOL Preparation Products And Raw materials

Raw materials

Benzene, 4-[(1E)-2-[3,5-bis(phenylmethoxy)phenyl]ethenyl]-1,2-bis(phenylmethoxy)- (E)-3,3',4,5'-TETRAMETHOXYSTILBENE 5-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-phenol Resveratrol 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-phenol

Preparation Products

PICEATANNOL Suppliers

Global( 349)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	+86-029-86333380 18829239519	sales06@tgybio.com	China	961	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7613	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	268	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58

Supplier	Advantage
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	58
Henan Fengda Chemical Co., Ltd	58
BINBO BIOLOGICAL CO.,LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Chengdu GLP biotechnology Co Ltd	58

View Lastest Price from PICEATANNOL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-22	Piceatannol 10083-24-6	US $0.00 / kg	1kg	98%	1000 kg	BINBO BIOLOGICAL CO.,LTD
2024-03-29	PICEATANNOL 10083-24-6	US $6.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2024-03-28	Piceatannol 10083-24-6	US $0.00 / kg	25kg	98%	Inquiry	PNP Biotech Co. Ltd

Piceatannol
10083-24-6
US $0.00 / kg
98%
BINBO BIOLOGICAL CO.,LTD

PICEATANNOL
10083-24-6
US $6.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

Piceatannol
10083-24-6
US $0.00 / kg
98%
PNP Biotech Co. Ltd

PICEATANNOL Spectrum

PICEATANNOL(10083-24-6)¹HNMR

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Resveratrol 3,5-DIHYDROXY-4'-METHOXYSTILBENE 3-O-BETA-D-GLUCOSIDE Resveratrol-13C6 3,5-DIHYDROXY-4'-BROMOSTILBENE Acetyl-trans-resveratrol

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TRANS-3,3',4,5'-TETRAHYDROXYSTILBENE PICEATANNOL PICEATANNOL (3,3',4,5'-TETRAHYDROXY-TRAN (e)-4-[2-(3,5dihydroxyphenyl)ethenyl]1,2-benzenediol 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol trans-Piceatannol (E)-3,3',4,5'-Tetrahydroxystilbene (E)-Piceatannol Astringenin Piceatannol,96% Piceatannol3,4,3',5'-Tetrahydroxy-trans-stilbene Piceatanl 5-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]benzene-1,3-diol 20MG/50MG/100G (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol (E)-3,3',4,5'-Stilbenetetrol 4-[(1E)-2-(3,5-DIHYDROXYPHENYL)ETHENYL]-1,2-BENZENEDIOL 3,3',4,5'-TETRAHYDROXYSTILBENE 3,3',4,5'-TETRAHYDROXY-TRANS-STILBENE 3,4,3',5'-TETRAHYDROXY-TRANS-STILBENE Piceatannol, (E)- Piceatannol - CAS 10083-24-6 - Calbiochem 1,2-Benzenediol,4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]- Piceatannol> Piceatannol ，>98% Resveratrol 3-Hydroxy Impurity Resveratrol Impurity 20 (trans-Piceatannol) NSC-622471 Piceatannol (Astringenin Beryl alcohol Piceatannol (6CI) 10083-24-6 Cell Signaling and Neuroscience BioChemical Lymphocyte Specific Kinase and Spleen Tyrosine Kinase (Lck, Syk) Kinase/Phosphatase Biology Non-Receptor Tyrosine Kinase Inhibitors Cell Biology Aromatics Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals chemical reagent pharmaceutical intermediate Protein Kinase Stilbenes (substituted) Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Inhibitors Syk phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract