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TYRPHOSTIN AG 879

CAS No.
148741-30-4
Chemical Name:
TYRPHOSTIN AG 879
Synonyms
AG 879;CS-2772;AG-879 100MG;AG 879;AG-879;TYRPHOSTIN 879;TYRPHOSTIN AG 879;Tyrphostin AG 879 (AG 879);TYRPHOSTIN AG 879 USP/EP/BP;AG 879 - CAS 148741-30-4 - Calbiochem;α-cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
CBNumber:
CB8383710
Molecular Formula:
C18H24N2OS
Molecular Weight:
316.46
MDL Number:
MFCD00236450
MOL File:
148741-30-4.mol
MSDS File:
SDS
Last updated:2023-07-12 17:23:30

TYRPHOSTIN AG 879 Properties

Boiling point 432.7±55.0 °C(Predicted)
Density 1.127±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO: at 26 mg/mlsoluble
pka 9.63±0.70(Predicted)
form Orange-yellow solid
color Yellow
Stability Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

TYRPHOSTIN AG 879 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T2067 Tyrphostin AG 879 99% (HPLC) 148741-30-4 5mg $160 2024-03-01 Buy
Cayman Chemical 10793 AG 879 ≥95% 148741-30-4 5mg $68 2024-03-01 Buy
Cayman Chemical 10793 AG 879 ≥95% 148741-30-4 10mg $109 2024-03-01 Buy
Cayman Chemical 10793 AG 879 ≥95% 148741-30-4 25mg $255 2024-03-01 Buy
Cayman Chemical 10793 AG 879 ≥95% 148741-30-4 50mg $476 2024-03-01 Buy
Product number Packaging Price Buy
T2067 5mg $160 Buy
10793 5mg $68 Buy
10793 10mg $109 Buy
10793 25mg $255 Buy
10793 50mg $476 Buy

TYRPHOSTIN AG 879 Chemical Properties,Uses,Production

Description

AG-879 (148741-30-4) inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC50 = 10 μM). No inhibition of EGF, or PDGF receptor phosphorylation is observed at typical working concentrations.

Uses

Tyrphostin AG 879 is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy and was shown to sensitize prostate cancer cells to apoptosis.

Definition

ChEBI: 3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a monoterpenoid.

in vitro

ag 879 has been widely used as a tyr kinase inhibitor specific for erbb2 and flk-1, a vegf receptor. the ic50 value for erbb2 and flk-1 was approximately 1 μm. ag 879 at 10 nm blocked the specific interaction between the tyr-kinase etk and pak1 (a cdc42/rac-dependent ser/thr kinase) in cell culture. ag 879 (10 nm) showed no inhibitory effects on the purified etk and pak1 directly in vitro, suggesting that this drug blocked the etk-pak1 pathway by targeting the highly sensitive kinase upstream of etk. src was insensitive to ag 879. fak was inhibited by 100 nm ag 879, but not by 10 nm ag879 [2]. ag 879 inhibited proliferation of human breast cancer cells through an effect involving inhibition of map kinase activation. ag 879 markedly inhibited the expression of the raf-1 gene, which encoded an upstream mapkkk. additionally, ag 879 inhibited the expression of her-2[3]. treatment with ag879 (20 μm) dramatically decreased proliferation with a variable increase in apoptosis in cell lines from human leiomyosarcoma (htb-114, htb-115, htb-88), rhabdomyosarcoma (htb-82, te-671), prostatic adenocarcinoma (pc-3), acute promyelocytic leukemia (hl-60) and histiocytic lymphoma (u-937) [4].

in vivo

in athymic nod/scid mice grafted with htb-114 or hl-60, administration of ag879 at 2 mg induced a decrease in cancer growth [4]. ag 879 administration (20 mg/kg) kept 50% of mice absolutely free of ras-induced sarcomas. in the nude mice carrying v-ha-ras transformed nih 3t3 cells, ag 879 dramatically reduced the size of the growing sarcomas [5].

References

1) Ohmichi et al. (1993), The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor; Biochemistry, 32 4650

TYRPHOSTIN AG 879 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 113)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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Amadis Chemical Company Limited
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Angel Pharmatech, Ltd. 17317130613 3358272972@qq.com China 3235 58

TYRPHOSTIN AG 879 Spectrum

2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (E)- AG-879 100MG TYRPHOSTIN 879 TYRPHOSTIN AG 879 (3,5-DI-T-BUTYL-4-HYDROXYBENZYLIDENE)THIOCYANOACETAMIDE AG 879 ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE ALPHA-CYANO-(3,5-DI-TERT-BUTYL-4-HYDROXY)THIOCINNAMAMIDE α-cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide (E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide 2-Propenethioamide,3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- (E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide 2-CYANO-3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)PROP-2-ENETHIOAMIDE (E)-3-AMINO-2-[(3,5-DITERT-BUTYL-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)METHYL]-3-SULFANYLPROP-2-ENENITRILE CS-2772 AG 879;AG-879 AG 879 - CAS 148741-30-4 - Calbiochem Tyrphostin AG 879 (AG 879) (2E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide TYRPHOSTIN AG 879 USP/EP/BP 148741-30-4 C18H24N2OS Cell Signaling and Neuroscience Cell Biology BioChemical Receptor Tyrosine Kinase Inhibitors Kinase/Phosphatase Biology Neurotrophin Inhibitors