- CAS No.
- Chemical Name:
- tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
- Molecular Formula:
- Molecular Weight:
- MDL Number:
- MOL File:
|solubility||H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow|
|color||White to Pale Yellow Waxy|
|EWG's Food Scores||1|
|NCI Drug Dictionary||tocophersolan|
Tocofersolan price More Price(11)
|Manufacturer||Product number||Product description||CAS number||Packaging||Price||Updated||Buy|
|Sigma-Aldrich||57668||D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate||9002-96-4||5g||$85.5||2023-06-20||Buy|
|Sigma-Aldrich||57668||D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate||9002-96-4||25g||$298||2023-06-20||Buy|
|TCI Chemical||T3118||α-Tocopherol Polyethylene Glycol Succinate||9002-96-4||5G||$69||2023-06-20||Buy|
|TCI Chemical||T3118||α-Tocopherol Polyethylene Glycol Succinate||9002-96-4||25G||$235||2023-06-20||Buy|
|Strem Chemicals||08-2180||DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M||9002-96-4||10ml||$23||2021-12-16||Buy|
Tocofersolan Chemical Properties,Uses,Production
Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.
tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e.
Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.
Vitamin E polyethylene glycol succinate is an esterified vitamin E
(tocopherol) derivative primarily used as a solubilizer or emulsifying
agent because of its surfactant properties. Structurally, it is
amphipathic and hydrophilic, unlike the tocopherols, and therefore
it is a water-soluble derivative that can be used in pharmaceutical
formulations such as capsules, tablets, hot-melt extrusion,
microemulsions, topical products, and parenterals. One of
the most important applications is its use as a vehicle for lipid-based
drug delivery formulations. It can also be used as a source of
Vitamin E polyethylene glycol succinate has been characterized with respect to its mechanism of action and studied as a Pglycoprotein inhibitor.
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.
Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.
Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.
Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.
GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Tocofersolan Preparation Products And Raw materials
|Shaanxi LonierHerb Bio Technology Co Ltd||+86-86-+86-86-029-87551862 +firstname.lastname@example.org||China||2434||58|
|Hebei Mojin Biotechnology Co., Ltd||15028179902 +email@example.com||China||10673||58|
|Hebei Crovell Biotech Co Ltdfirstname.lastname@example.org||China||5998||58|
|Shaanxi Haibo Biotechnology Co., Ltdemail@example.com||China||1001||58|
|Capot Chemical Co.,Ltd.||571-85586718 +firstname.lastname@example.org||China||29811||60|
|Henan Tianfu Chemical Co.,Ltd.||+86-0371-55170693 +email@example.com||China||21975||55|
|Nanjing ChemLin Chemical Industry Co., Ltd.||firstname.lastname@example.org||CHINA||3012||60|
|career henan chemical email@example.com||China||29922||58|
|Hebei Guanlang Biotechnology Co., Ltd.||+firstname.lastname@example.org||China||8871||58|
|Shanghai Worldyang Chemical Co.,Ltd.||+email@example.com||China||876||58|
View Lastest Price from Tocofersolan manufacturers
|Image||Update time||Product||Price||Min. Order||Purity||Supply Ability||Manufacturer|
|US $0.00-0.00 / kg||1kg||99%||50tons||Wuhan Han Sheng New Material Technology Co.，Ltd|
|US $0.00 / KG||1KG||99%||50000KG/month||Hebei Mojin Biotechnology Co., Ltd|
|US $0.00 / KG||1KG||99%||500000kg||Hebei Guanlang Biotechnology Co., Ltd.|