Celiprolol
- CAS No.
- 56980-93-9
- Chemical Name:
- Celiprolol
- Synonyms
- Edsivo;Selectol;-diethyl-;celiptolol;CELIPROLOL;dl-Celiprolol;Celiprolol Base;(R,S)-Celiprolol;Racemic Celiprolol;Celiprolol USP/EP/BP
- CBNumber:
- CB8411567
- Molecular Formula:
- C20H33N3O4
- Molecular Weight:
- 379.49
- MDL Number:
- MFCD00864577
- MOL File:
- 56980-93-9.mol
- MSDS File:
- SDS
| Melting point | 110-112° |
|---|---|
| Boiling point | 586.5±50.0 °C(Predicted) |
| Density | 1.114±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform (slightly), Methanol (Slightly) |
| pka | pKa ～9.7 (Uncertain) |
| form | Solid |
| color | Yellow |
| Water Solubility | 22.9mg/L(22.5 ºC) |
| CAS DataBase Reference | 56980-93-9(CAS DataBase Reference) |
| FDA UNII | DRB57K47QC |
| ATC code | C07AB08 |
Celiprolol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C254503 | Celiprolol | 56980-93-9 | 5mg | $125 | 2021-12-16 | Buy |
| Usbiological | 237337 | Diethyl | 56980-93-9 | 1ml | $192 | 2021-12-16 | Buy |
| Usbiological | 446762 | Diethyl | 56980-93-9 | 100mg | $305 | 2021-12-16 | Buy |
| Usbiological | 446765 | Diethyl [ | 56980-93-9 | 100mg | $319 | 2021-12-16 | Buy |
| Usbiological | 009452 | Diethyl- | 56980-93-9 | 1mg | $403 | 2021-12-16 | Buy |
Celiprolol Chemical Properties,Uses,Production
Originator
Selectol,Chemie Linz,Austria,1983
Uses
Celiprolol is an intermediate in the synthesis of Celiprolol Hydrochloride (C254500). Celiprolol is a cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.
Definition
ChEBI: 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea is an aromatic ketone.
Manufacturing Process
3-Acetyl-4-hydroxyaniline, in solution in pyridine, is reacted with dimethylcarbamoyl chloride at room temperature to give N-(3-acetyl-4- hydroxy)phenyl-N'-dimethylurea, which after evaporating the pyridine, taking up the residue in chloroform and evaporating the latter, is obtained in a crystalline form. Melting point: 160°-162°C. After reaction of the product in alkaline aqueous solution, with epichlorohydrin, N-[3-acetyl-4-(2',3'-epoxy)- propoxy]-phenyl-N'-dimethylurea (melting point: 98°-102°C) is obtained, and this, in turn, is reacted with excess tert-butylamine in aqueous solution at room temperature to give N-[3-acetyl-4-(3'-tert-butylamino-2'-hydroxy)- propoxy)-phenyl-N'-dimethylurea of melting point: 120°-122°C.
Therapeutic Function
Beta-adrenergic blocker
Celiprolol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| Guangzhou PI PI Biotech Inc | +86-020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3635 | 55 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd. | 027-51831887 15337167856 | hubeixinyuanshun@163.com | China | 10305 | 58 |
| Supplier | Advantage |
|---|---|
| Baoji Guokang Healthchem co.,ltd | 58 |
| Mainchem Co., Ltd. | 55 |
| Guangzhou PI PI Biotech Inc | 55 |
| LGM Pharma | 70 |
| Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd. | 58 |
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