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Bleomycin sulfate

Bleomycin sulfate
Bleomycin sulfate structure
CAS No.
9041-93-4
Chemical Name:
Bleomycin sulfate
Synonyms
BLEO;BLEXANE;BLENOXANE;Blenmycins;NSC-125066;Blocamicina;Blenoxane, Bleo;BleoMycin Sufate;BLEMOYCIN SULFATE;BleoMycin coMplex
CBNumber:
CB8412175
Molecular Formula:
C110H168N34O46S7
Formula Weight:
2927.17
MOL File:
9041-93-4.mol

Bleomycin sulfate Properties

Melting point:
200-204°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: 20 mg/mL
form 
powder
color 
white
Water Solubility 
Soluble in water or DMSO
Merck 
14,1318
CAS DataBase Reference
9041-93-4(CAS DataBase Reference)
FDA UNII
7DP3NTV15T
NCI Dictionary of Cancer Terms
bleomycin sulfate
NCI Drug Dictionary
bleomycin sulfate
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H340-H351-H361
Precautionary statements  P202-P405-P501a-P201-P280-P308+P313-P281
Hazard Codes  T,Xi
Risk Statements  46-40-36/37/38-63
Safety Statements  53-36/37-45-36-26
WGK Germany  3
RTECS  EC5991990
10
HS Code  2941906000

Bleomycin sulfate price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B1141000 Bleomycin sulfate European Pharmacopoeia (EP) Reference Standard 9041-93-4 $190 2021-03-22 Buy
Sigma-Aldrich 1076308 Bleomycin sulfate 9041-93-4 15mg $733 2021-03-22 Buy
Sigma-Aldrich B5507 Bleomycin sulfate from Streptomyces verticillus crystalline, 1.5-2.0?U/mg 9041-93-4 15 units $744 2021-03-22 Buy
Sigma-Aldrich B8416 Bleomycin sulfate from Streptomyces verticillus 1.5-2.0?units/mg solid, BioReagent, suitable for cell culture 9041-93-4 15 units $921 2021-03-22 Buy
Sigma-Aldrich B2434 Bleomycin sulfate from Streptomyces verticillus BioXtra, crystalline 9041-93-4 20mg $975 2021-03-22 Buy

Bleomycin sulfate Chemical Properties,Uses,Production

Chemical Properties

White Powder

Uses

A group of related glycopeptide antibiotics. Bleomycin A2 is the main component of the bleomycin employed clinically. Antineoplastic

Uses

Bleomycin is a complex of 11 glycopeptide antitumour antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight . Bleomycins have found clinical application in the treatment of a range of tumours. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

Uses

Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

brand name

Blenoxane (Bristol-Myers Squibb).

General Description

Bleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.

Clinical Use

Bleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.

Side effects

It is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.

Veterinary Drugs and Treatments

Bleomycin has occasionally been used as adjunctive treatment of lymphomas, squamous cell carcinomas, teratomas, and nonfunctional thyroid tumors in both dogs and cats. Recent work has demonstrated that bleomycin may be promising for intralesional treatment for a variety of localized tumors with or without concomitant electropermeabilization.

Bleomycin sulfate Preparation Products And Raw materials

Raw materials

Preparation Products


Bleomycin sulfate Suppliers

Global( 303)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Fluoropharm Co., Ltd.
+8613336034509
+86 0571-85586753 sales@fluoropharm.com China 982 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26751 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58

View Lastest Price from Bleomycin sulfate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Bleomycin sulfate
9041-93-4
US $75.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-07-13 Bleomycin sulfate
9041-93-4
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 Bleomycin sulfate
9041-93-4
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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