Vagistat
- CAS No.
- 65899-73-2
- Chemical Name:
- Vagistat
- Synonyms
- Trosyl;Trosyd;Zoniden;vagistat;UK-20349;Fungibacid;Vagistat 1;ioconazole;Gyno-Trosyd;TIOCONAZOLE
- CBNumber:
- CB8416704
- Molecular Formula:
- C16H13Cl3N2OS
- Molecular Weight:
- 387.71
- MDL Number:
- MFCD00057276
- MOL File:
- 65899-73-2.mol
- MSDS File:
- SDS
| Melting point | 79-81oC |
|---|---|
| Boiling point | 534.5±50.0 °C(Predicted) |
| Density | 1.3115 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| RTECS | NI4480000 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol. |
| pka | 6.66±0.12(Predicted) |
| form | powder |
| color | white to off-white |
| CAS DataBase Reference | 65899-73-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | S57Y5X1117 |
| ATC code | D01AC07,G01AF08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H361d-H410 | |||||||||
| Precautionary statements | P202-P273-P280-P301+P312-P302+P352-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934990002 | |||||||||
| NFPA 704 |
|
Vagistat price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2808 | Tioconazole | 65899-73-2 | 400MG | $170 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP687 | Tioconazole impurity standard British Pharmacopoeia (BP) Reference Standard | 65899-73-2 | 100MG | $229 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP645 | Tioconazole British Pharmacopoeia (BP) Reference Standard | 65899-73-2 | 100MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1667439 | Tioconazole United States Pharmacopeia (USP) Reference Standard | 65899-73-2 | 200mg | $157.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 03907 | Tioconazole 97% | 65899-73-2 | 10g | $183 | 2024-03-01 | Buy |
Vagistat Chemical Properties,Uses,Production
Description
Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species.
Chemical Properties
White powder EINECS: 265-973-8
Originator
Pfizer (United Kiugdom)
Uses
Potent inhibitor of cytochrome-P450
Uses
antithrombotic
Uses
Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, tioconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.
Definition
ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.
Manufacturing Process
A solution of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (1.5 g, 5.8 mmol) dissolved in dry tetrahydrofuran (10 ml) was added to a stirred suspension of sodium hydride (0.39 g, as 80% dispersion in oil, 16 mmol) in dry tetrahydrofuran (10 ml) and warmed to 70°C for 90 minutes. The mixture was cooled in ice and a solution of 2-chloro-3- chloromethylthiophene (8.8 mmol) in dry tetrahydrofuran was added. The mixture was heated at 70°C for 3 hours and allowed to stir at room temperature overnight. The solvent was removed under vacuum and the residue stirred with dry ether (200 ml). The ether solution was filtered through Celite and saturated with hydrogen chloride gas to precipitate an oil which was solidified by trituration with ether and ethyl acetate. The solid product was collected and recrystallized from a mixture of acetone and diisopropyl ether to give the product, melting point 168°C to 170°C.
brand name
TROSYL
Therapeutic Function
Antifungal
Antimicrobial activity
Tioconazole is a broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.
Pharmacokinetics
Tioconazole is normally not absorbed after topical application to the skin [173]. On vaginal application of an ovulum containing 300 mg tioconazole, a serum concentration of 21 μg/mL was observed after 8 h.
Clinical Use
1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles.
Side effects
Local irritations such as itching, burning sensations, erythema, and dermatitis, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
Vagistat Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3657 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Related articles
- Pharmacodynamics and Toxicity of Tioconazole
- tioconazole inhibits sterol biosynthesis by the inhibition of cytochrome P450-dependent C-14a-demethylation of lanosterol, pre....
- Mar 30，2022
View Lastest Price from Vagistat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-14 | Vagistat
65899-73-2
|
US $0.00-0.00 / kg | 100kg | 99% | 20 tons | Wuhan Han Sheng New Material Technology Co.，Ltd | |
 |
2023-08-29 | Vagistat
65899-73-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2021-11-27 | Vagistat
65899-73-2
|
US $10.00 / g | 1g | 99.99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD |
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