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Benzhydrol

Benzhydrol
Benzhydrol structure
CAS No.
91-01-0
Chemical Name:
Benzhydrol
Synonyms
NSC 32150;benzydrol;BENZHYDROL;BNEZHYDROL;BENZOHYDROL;Benzhydrol >4-Methyl-αBENZHYDROL 99%;BENZHYDROL 99+%;DIPHENYLMETHANOL
CBNumber:
CB8417044
Molecular Formula:
C13H12O
Formula Weight:
184.24
MOL File:
91-01-0.mol

Benzhydrol Properties

Melting point:
65-67 °C (lit.)
Boiling point:
297-298 °C (lit.)
Density 
1.0120 (rough estimate)
vapor pressure 
0.000076 hPa (20 °C)
refractive index 
1.5727 (estimate)
Flash point:
160 °C
storage temp. 
Store below +30°C.
solubility 
0.52g/l insoluble
form 
Crystalline Solid
pka
13.55±0.20(Predicted)
color 
White to beige
Water Solubility 
Slightly soluble in water.
Merck 
14,1090
BRN 
1424379
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids.
CAS DataBase Reference
91-01-0(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
S4HQ1H8OWD
NIST Chemistry Reference
Benzenemethanol, «alpha»-phenyl-(91-01-0)
EPA Substance Registry System
Benzenemethanol, .alpha.-phenyl- (91-01-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H303-H315-H319-H335-H320
Precautionary statements  P264-P305+P351+P338+P337+P313-P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  2
RTECS  DC7452000
Hazard Note  Irritant
TSCA  Yes
HS Code  29062900
Toxicity LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg

Benzhydrol price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B4856 Diphenylmethanol 99% 91-01-0 5g $14.9 2021-03-22 Buy
Sigma-Aldrich BP1119 Diphenylmethanol British Pharmacopoeia (BP) Reference Standard 91-01-0 $196 2021-03-22 Buy
Sigma-Aldrich 1051602 Cyclizine impurity B United States Pharmacopeia (USP) Reference Standard 91-01-0 50mg $366 2021-03-22 Buy
TCI Chemical D0898 Benzhydrol >99.0%(GC) 91-01-0 25g $15 2021-03-22 Buy
TCI Chemical D0898 Benzhydrol >99.0%(GC) 91-01-0 500g $72 2021-03-22 Buy

Benzhydrol Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

  1. Benzhydrols are industrially important compounds. On oxidation Benzhydrols yields Benzophenone, which are useful synthones for fullerenes, bioactive oxygen heterocycles, dyes and medicines. Various Cr (VI) and other oxidizing agents are used for oxidizing benzhydrol.
  2. Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.
  3. Intermediate in the preparation of Modafinil (M482500).

Reactions

Benzhydrol is oxidized to benzophenone, by sodium hypochlorite (commonly known as bleach) in the presence of a phase-transfer catalyst.
Synthesis: In a 20-mL green capped vial, place 1.5 mL of ethyl acetate, 100 mg (0.54 mmol) of benzhydrol and a few drops of methyltricaprylammonium chloride solution (Stark's catalyst or tricaprylmethylammonium chloride). Add a half-inch magnetic stirring bar, and stir until all reagents are dissolved. Cool the solution in an ice bath and add 2 mL of 5% NaOCl (aq) (bleach) dropwise using a 2.5- mL syringe. After the addition of the hypochlorite is complete, allow the reaction to stir for five minutes in the ice-water bath and then stir for a period of one hour at room temperature.
Reduction of benzophenone to benzhydrol
Reduction of benzophenone to benzhydrol.
4MPDC (4-Methyl pyridinium di chromate) is used as oxidizing agent to oxidize benzhydrol. PDC is a mild and selective oxidizing agent and is soluble in water and many organic solvents. Therefore, advantage over inorganic dichromate.

Synthesis Reference(s)

Canadian Journal of Chemistry, 50, p. 3058, 1972 DOI: 10.1139/v72-485
Journal of the American Chemical Society, 55, p. 391, 1933 DOI: 10.1021/ja01328a057
Tetrahedron Letters, 29, p. 139, 1988 DOI: 10.1016/S0040-4039(00)80036-2

Purification Methods

Crystallise benzhydrol from hot H2O or pet ether (b 60-70o), pet ether containing a little *benzene, from CCl4, or EtOH (1mL/g). An additional purification step includes passage of a *benzene solution through an activated alumina column. It sublimes in a vacuum. Also recrystallise it three times from MeOH/H2O [Naguib J Am Chem Soc 108 128 1986]. [Beilstein 6 IV 4648.]

Benzhydrol Preparation Products And Raw materials

Raw materials

Preparation Products


Benzhydrol Suppliers

Global( 408)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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View Lastest Price from Benzhydrol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Benzhydrol
91-01-0
US $0.00 / Kg/Bag 1KG 99% 2000mt/year Jinan Finer Chemical Co., Ltd
2021-10-21 Benzhydrol
91-01-0
US $1.00-500.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-09-19 Benzhydrol
91-01-0
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.

Benzhydrol Spectrum


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