5-(N,N-HEXAMETHYLENE)-AMILORIDE
- CAS No.
- 1428-95-1
- Chemical Name:
- 5-(N,N-HEXAMETHYLENE)-AMILORIDE
- Synonyms
- hma;Amilo;5-HMA;HMA-5;amipromizide;Hexamethyleneamiloride;5-(N,N-HEXAMETHYLENE)-AMILORIDE;AMILORIDE,5-(N,N-HEXAMETHYLENE)-;HMA (5-(N,N-Hexamethylene)amiloride);5-(N,N-HEXAMETHYLENE)-AMILORIDE USP/EP/BP
- CBNumber:
- CB8418632
- Molecular Formula:
- C12H18ClN7O
- Molecular Weight:
- 311.77
- MDL Number:
- MFCD00069211
- MOL File:
- 1428-95-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
5-(N,N-HEXAMETHYLENE)-AMILORIDE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9561 | 5-(N,N-Hexamethylene)amiloride | 1428-95-1 | 25mg | $113 | 2024-03-01 | Buy |
| Sigma-Aldrich | A9561 | 5-(N,N-Hexamethylene)amiloride | 1428-95-1 | 100mg | $151.2 | 2024-03-01 | Buy |
| Cayman Chemical | 29788 | 5-(N,N-hexamethylene)-Amiloride | 1428-95-1 | 10mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 29788 | 5-(N,N-hexamethylene)-Amiloride | 1428-95-1 | 25mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 29788 | 5-(N,N-hexamethylene)-Amiloride ≥98% | 1428-95-1 | 100mg | $290 | 2021-12-16 | Buy |
5-(N,N-HEXAMETHYLENE)-AMILORIDE Chemical Properties,Uses,Production
Description
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride with diverse biological activities. It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 μM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 μM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 μM. It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7. HMA (40 μM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells. HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.
Definition
ChEBI: A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.
Biochem/physiol Actions
Inhibitor of Na+/H+ antiport.
5-(N,N-HEXAMETHYLENE)-AMILORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
View Lastest Price from 5-(N,N-HEXAMETHYLENE)-AMILORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-09 | 5-(N,N-HEXAMETHYLENE)-AMILORIDE USP/EP/BP
1428-95-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- 5-(N,N-HEXAMETHYLENE)-AMILORIDE USP/EP/BP
1428-95-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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