ROQUEFORTINE C
- CAS No.
- 58735-64-1
- Chemical Name:
- ROQUEFORTINE C
- Synonyms
- Nsc292134;Aids031208;ROQUEFORTIN;Aids-031208;RORIFONE95%;ROQUEFORTINE;ROQUEFORTINE C;ISOROQUEFORTINE C;PYRAZINO1215PYRROLO23BINDOLE143H5AH;roquefortine from penicillium*roqueforti
- CBNumber:
- CB8422875
- Molecular Formula:
- C22H23N5O2
- Molecular Weight:
- 389.45
- MDL Number:
- MFCD00133802
- MOL File:
- 58735-64-1.mol
| Melting point | 202-205℃ |
|---|---|
| Boiling point | 768.3±60.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | chloroform: soluble1mg/mL |
| form | White to off-white solid. |
| pka | 11.10±0.40(Predicted) |
| Stability | Hygroscopic |
| FDA UNII | 4VW6U94XFK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P280 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UQ4730500 |
| HS Code | 2941900000 |
ROQUEFORTINE C price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0406 | Roquefortine C ≥98% (HPLC), from Penicillium roqueforti | 58735-64-1 | 500μg | $555 | 2024-03-01 | Buy |
| Cayman Chemical | 15376 | Roquefortine C ≥98% | 58735-64-1 | 500μg | $171 | 2024-03-01 | Buy |
| Cayman Chemical | 15376 | Roquefortine C ≥98% | 58735-64-1 | 1mg | $305 | 2024-03-01 | Buy |
| Usbiological | 207386 | Roquefortine C | 58735-64-1 | 500ug | $316 | 2021-12-16 | Buy |
| Usbiological | R2999-45 | Roquefortine C | 58735-64-1 | 500ug | $523 | 2021-12-16 | Buy |
ROQUEFORTINE C Chemical Properties,Uses,Production
Description
Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-
Description
The third alkaloid isolated from a surface culture of Penicillium roqueforti, roquefortine C is present in only small quantities and the amount obtained is insufficient for the full structure to be established.
Uses
Roquefortine C is a potent tremorgenic mycotoxin originally isolated from Penicillium roqueforti in 1975 in Japan. Parallel research by Scott and colleagues lead to the structure elucidation of roquefortine C as an unusual diketopiperazine formed by coupling a prenylated tryptophan and histidine. Roquefortine C was subsequently found to be produced by a diverse range of fungi, most notably Penicillium species. Roquefortine is an important mycotoxin as low levels can be found in foodstuffs.
Uses
Roquefortine C has been used as a standard for the quantification of roquefortine C by high-performance liquid chromatography (HPLC). It has also been used as a standard for the quantification of roquefortine C by liquid chromatography-mass spectrometry (LC?MS/MS).
Definition
ChEBI: Roquefortine C is a pyrroloindole.
Biochem/physiol Actions
Roquefortine C is a paralytic neurotoxin of a dioxopiperazine structure produced by a diverse range of fungi, most notably Penicillium species. It has been found in blue cheese and in many other food products due to natural occurrence and contamination. Roquefortine C was found to be active on a wide range of organisms. It inhibits the growth of Gram-positive bacteria, and cockerels treated with roquefortine lost their righting reflex and died within 8-12 hours. Mice injected with roquefortine C experienced neurotoxic properties. Roquefortine C was also reported to inhibit cytochrome P450 as well as tubulin polymerization.
References
Ohmono et al., Agr. Bioi. Chem., 39, 1333 (1975)
ROQUEFORTINE C Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
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