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Abacavir sulfate

Abacavir sulfate
Abacavir sulfate structure
CAS No.
188062-50-2
Chemical Name:
Abacavir sulfate
Synonyms
ZIAGEN;DRG 0257;Hsdb 7154;ABC sulfate;Unii-J220T4J9Q2;1592U89 sulfate;bacavir sulfate;ABACAVIR SULFATE;ABACAVIR SULPHATE;Abacavir Hemisulfate
CBNumber:
CB8425548
Molecular Formula:
C28H38N12O6S
Formula Weight:
670.74
MOL File:
188062-50-2.mol

Abacavir sulfate Properties

Melting point:
222-225°C
storage temp. 
-20°C Freezer
solubility 
H2O: ≥17mg/mL
form 
powder
color 
white to tan
optical activity
[α]/D -30 to -40°, c = 0.5 in methanol
CAS DataBase Reference
188062-50-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H351-H361
Precautionary statements  P280-P281
Hazard Codes  Xn
Risk Statements  63-40
Safety Statements  36/37
WGK Germany  3
HS Code  2933595960

Abacavir sulfate price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1256 Abacavir sulfate 188062-50-2 500mg $81.3 2018-11-20 Buy
Sigma-Aldrich 1000408 Abacavir sulfate United States Pharmacopeia (USP) Reference Standard 188062-50-2 200mg $348 2018-11-13 Buy
Sigma-Aldrich SML0089 Abacavir sulfate ≥98% (HPLC) 188062-50-2 50mg $357 2018-11-13 Buy
Sigma-Aldrich SML0089 Abacavir sulfate ≥98% (HPLC) 188062-50-2 10mg $88.5 2018-11-13 Buy
Sigma-Aldrich Y0001551 Abacavir for system suitability European Pharmacopoeia (EP) Reference Standard 188062-50-2 y0001551 $179 2018-11-23 Buy

Abacavir sulfate Chemical Properties,Uses,Production

Description

Abacavir sulfate was first launched as Ziagen in the US for the treatment of human immunodeficiency virus (HIV) infection, in combination with other antiretroviral drugs. Abacavir is a carbocyclic nucleoside reverse transcriptase inhibitor (nRTI); it is one of the most potent anti-HIV agents to date. The compound can be prepared by an enantioselective synthesis involving palladium-catalyzed coupling of a chloropurine with a carbocyclic allylic diacetate. In vitro, Abacavir is a potent and selective inhibitor of HIV-1 and HIV-2 replication. Resistance to Abacavir develops more slowly than for other anti-HIV agents. Abacavir is highly synergistic with protease inhibitors such as Amprenavir. In clinical trials for HIV infections in adults, it produced durable suppression in viral load. Combinations with different protease inhibitors such as Nelfinavir, Saquinavir or Indinavir markedly reduced plasma viral load to undetectable levels for at least 48 weeks, and significantly raised CD4+ cell counts in adults with HIV infection, especially nRTI-naive patients. Abacavir has a good oral availability and its penetration into CSF is much more significant than for other anti-HIV drugs. The two major metabolites identified in humans were the 5'-carboxylate and the 5'-glucuronide, mainly excreted via the renal route.

Chemical Properties

White Solid

Originator

Glaxo Wellcome (UK)

Uses

A nucleoside reverse transcriptase inhibitor (NRTI)

Uses

antiviral

Uses

anti-AIDS drug

Definition

ChEBI: An azaheterocycle sulfate salt that is the sulfate salt of the HIV-1 reverse transcriptase inhibitor abacavir.

brand name

Ziagen (GlaxoSmithKline).

Abacavir sulfate Preparation Products And Raw materials

Raw materials

Preparation Products


Abacavir sulfate Suppliers

Global( 153)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 308 58
Chongqing Chemdad Co., Ltd +86-13650506873
sales@chemdad.com CHINA 30864 58
Shanghai Bioman Pharma Limited 021-33738120 15000110506
021-23025272 info@bioman.com.cn China 52 62
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Abacavir sulfate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Abacavir sulfate
188062-50-2
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-03-12 Abacavir Sulphate
188062-50-2
US $200.00 / KG 10UG 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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