NEORUSCOGENIN
- CAS No.
- 17676-33-4
- Chemical Name:
- NEORUSCOGENIN
- Synonyms
- NEORUSCOGENIN;Einecs 241-660-1;spirost-5,25(27)-dien-1β,3β-diol;spirost-5,25(27)-dien-1β,3β-diol;SPIROSTA-5,25(27)-DIENE-1B,3B-DIOL;Spirosta-5,25(27)-diene-1β,3β-diol;spirosta-5,25(27)-diene-1beta,3beta-diol;Spirosta-5,25(27)-diene-1,3-diol,(1b,3b)-;Spirosta-5,25(27)-diene-1,3-diol, (1β,3β)-;Spirosta-5,25(27)-diene-1,3-diol, (1.beta.,3.beta.)-
- CBNumber:
- CB8440721
- Molecular Formula:
- C27H40O4
- Molecular Weight:
- 428.61
- MDL Number:
- MFCD00210534
- MOL File:
- 17676-33-4.mol
- MSDS File:
- SDS
| Melting point | 196～198℃ |
|---|---|
| Density | 1.19±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 4°C, protect from light |
| solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| form | crystalline solid |
| Boiling point | 566.6±50.0 °C(Predicted) |
| pka | 14.55±0.70(Predicted) |
| LogP | 4.210 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | D4E4KC2TUK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
NEORUSCOGENIN price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15567 | Neoruscogenin ≥95% | 17676-33-4 | 1mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 15567 | Neoruscogenin ≥95% | 17676-33-4 | 5mg | $477 | 2024-03-01 | Buy |
| Cayman Chemical | 15567 | Neoruscogenin ≥95% | 17676-33-4 | 10mg | $834 | 2024-03-01 | Buy |
| Usbiological | 285002 | Neoruscogenin | 17676-33-4 | 5mg | $333 | 2021-12-16 | Buy |
| TRC | N390150 | Neoruscogenin | 17676-33-4 | 5mg | $360 | 2021-12-16 | Buy |
NEORUSCOGENIN Chemical Properties,Uses,Production
Uses
Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.
Biological Activity
neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα [1]. neoruscogenin is a natural sapogenin extracted from butcher’s broom (rusci rhizoma, ruscus aculeatus, ruscaceae) [2].rar-related orphan receptor alpha (rorα) is a nuclear receptor that participates in the transcriptional regulation of some genes involved incircadian rhythm. genetic studies have revealed that rorα plays an important role in the development of the central nervous system and has been associated with genetic lesions in mice [3].
in vitro
in confluent human microvascular endothelial cells (hmec-1), pre-treatment with neoruscogenin slightly decreased the permeability at concentrations up to 100 μm (71.8%). the ec50 of neoruscogenin against the nuclear receptor rorα was 110 nm [1].
in vivo
in mice, oral administration of neoruscogenin (3 mg/kg/d) for seven days up-regulated the expression of several rorα-inducible genes in the liver [1].
References
[1] helleboid s, haug c, lamottke k, et al. the identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα (nr1f1)[j]. journal of biomolecular screening, 2013: 1087057113497095.
[2] barbi m, willer e a, rothenhfer m, et al. spirostanol saponins and esculin from rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells[j]. phytochemistry, 2013, 90: 106-113.
[3] giguère v. orphan nuclear receptors: from gene to function 1[j]. endocrine reviews, 1999, 20(5): 689-725.
NEORUSCOGENIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | chem1022@hengdian-group.com | China | 1469 | 58 |
View Lastest Price from NEORUSCOGENIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Neoruscogenin
17676-33-4
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-14 | NEORUSCOGENIN
17676-33-4
|
US $1.00 / KG | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- Neoruscogenin
17676-33-4
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- NEORUSCOGENIN
17676-33-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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