ChemicalBook >> CAS DataBase List >>KN-62
KN-62
- CAS No.
- 127191-97-3
- Chemical Name:
- KN-62
- Synonyms
- KN-2;N 62;KN-62;CS-756;KN-62 97%;KN-62,97%;KN 62;KN-2;KN-62, 99+%;KN 62; KN62;KN-62, >=98%
- CBNumber:
- CB8443368
- Molecular Formula:
- C38H35N5O6S2
- Molecular Weight:
- 721.84
- MDL Number:
- MFCD00083180
- MOL File:
- 127191-97-3.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 92-94°C |
|---|---|
| Boiling point | 964.7±75.0 °C(Predicted) |
| Density | 1.388 |
| storage temp. | -20°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL |
| form | solid |
| pka | 4.07±0.13(Predicted) |
| color | white |
| CAS DataBase Reference | 127191-97-3(CAS DataBase Reference) |
| FDA UNII | 63HM46XPOW |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 29339980 |
KN-62 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I2142 | KN-62 ≥95%, powder | 127191-97-3 | .5mg | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | 422706 | KN-62 | 127191-97-3 | 1mg | $181 | 2023-01-07 | Buy |
| Alfa Aesar | J62444 | KN-62 | 127191-97-3 | 1mg | $103.65 | 2024-03-01 | Buy |
| Alfa Aesar | J62444 | KN-62 | 127191-97-3 | 10mg | $604.65 | 2024-03-01 | Buy |
| Cayman Chemical | 13318 | KN-62 ≥98% | 127191-97-3 | 1mg | $49 | 2024-03-01 | Buy |
KN-62 Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,
Uses
A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II
Uses
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Definition
ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.
General Description
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
Biological Activity
Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.
storage
-20°C (desiccate)
KN-62 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 176)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
127191-97-3(KN-62)Related Search:
N-Aminoethylpiperazine
1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE
1-(3-PHENYLPROPYL)PIPERAZINE
5-Isoquinolinesulfonic acid
1-Acetylpiperazine
4-Methyl-1-piperazineethanamine
1-Piperazineethanamine,N,4-dimethyl-(9CI)
1-(4-phenylpiperazin-1-yl)propan-2-amine
1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE
1-ETHYL-4-PHENYLPIPERAZINE
1of4
1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR
KN-62 97%
KN-62, 99+%
4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid
1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester,
5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
(s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
(1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL)4-PHENYLPIPERAZINE) KN 62
(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine
4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester
5-Isoquinolinesulfonic acid 4-[(S)-2-[[(isoquinolin-5-yl)sulfonyl]methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
KN-62,97%
4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-
3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacid ester KN-62
(S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate
(S)-4-(2-(N-Methylisoquinoline-5-sulfonaMido)-3-oxo-3-(4-phenylp
KN-62, >=98%
(S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonat
KN-62;KN 62; KN62
(S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl is
KN-62
4-[(2S)-2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]-3-OXO-3-(4-PHENYL-1-PIPERAZINYL)PROPYL] PHENYL ISOQUINOLINESULFONIC ACID ESTER
1-[N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL]-4-PHENYLPIPERAZINE
5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)MethylaMino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester, (S)-
(S)-5-ISOQUINOLINESULFONIC ACID 4-(2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]- 3-OXO-3-[4-PHENYL-1-PIPERAZINYL]PROPYL)PHENYL ESTER
CS-756
KN-62 - CAS 127191-97-3 - Calbiochem
KN 62;KN-2
KN-2
(S)-4-(2-(N-methylisoquinoline-5-suNLFonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-suNLFonate
N 62
KN 62; KN62
KN-62 USP/EP/BP
[4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate
noncompetitive antagonism,KN-62,KN 62,inhibit,P2XRs,Calmodulin-dependent protein kinases,HEK293 cells,P2X Receptor,Calmodulin-dependent kinases,CaMK,Inhibitor,autophosphorylation,KN62
127191-97-3
C38H35O6S2
C38H35N5O6S2
Cell Biology
Cell Signaling and Neuroscience
Calcium/Calmodulin-Dependent Protein Kinase (CaMK)
BioChemical
Kinase/Phosphatase Biology
Serine/Threonine Kinase Inhibitors
Inhibitor
Protein Kinase
Protein Kinase Inhibitors and Activators