Methenolone acetate
- CAS No.
- 434-05-9
- Chemical Name:
- Methenolone acetate
- Synonyms
- nibal;sh567;sh567a;sq16496;PriMo A;pirmo a;NSC 74226;primonabol;17-Acetate;premobolan
- CBNumber:
- CB8446910
- Molecular Formula:
- C22H32O3
- Molecular Weight:
- 344.49
- MDL Number:
- MFCD00864181
- MOL File:
- 434-05-9.mol
| Melting point | 138-139° |
|---|---|
| Boiling point | 419.57°C (rough estimate) |
| Density | 1.0906 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 3.6 mg/mL (10.45 mM) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1/C22H32O3/c1-13-11-16(24)12-15-5-6-17-18-7-8-20(25-14(2)23)21(18,3)10-9-19(17)22(13,15)4/h11,15,17-20H,5-10,12H2,1-4H3/t15-,17-,18-,19-,20-,21-,22-/s3 |
| InChIKey | PGAUJQOPTMSERF-MQEWATRANA-N |
| SMILES | [C@]12([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC[C@@]1([H])CC(=O)C=C(C)[C@]21C)OC(=O)C |&1:0,4,6,10,12,16,24,r| |
| CAS DataBase Reference | 434-05-9(CAS DataBase Reference) |
| FDA UNII | W75590VPKQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H360-H351-H362 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313 |
Methenolone acetate price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 099254 | Methenolone acetate 95+% | 434-05-9 | 1g | $525 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0006383 | METHENOLONE ACETATE 95.00% | 434-05-9 | 10MG | $739.2 | 2021-12-16 | Buy |
| Matrix Scientific | 099254 | Methenolone acetate 95+% | 434-05-9 | 5g | $855 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0006383 | METHENOLONE ACETATE 95.00% | 434-05-9 | 100MG | $1871.1 | 2021-12-16 | Buy |
| Crysdot | CD33000297 | Methenoloneacetate 98+% | 434-05-9 | 10g | $750 | 2021-12-16 | Buy |
Methenolone acetate Chemical Properties,Uses,Production
Description
Methenolone acetate (Brand name: Primobolan) is a synthetic, orally active anabolic-androgenic steroid and dihydrotestosterone (DHT) derivative. It can be used for the treatment of bone marrow disease and anemia. Methenolone acetate is known for its higher therapeutic efficiency and lower hepatic toxicity compared with its 17 alpha- alkylated analogs. However, it is frequently abused in human sports because of its capability of increasing muscle strength as well as promoting performance and aggressiveness. It is capable of enhancing performance in racehorses.
Chemical Properties
White Solid
Originator
Primobolan ,Schering ,W. Germany,1961
Uses
Methenolone acetate is an anabolic steroid. This is a controlled substance.
Definition
ChEBI: Methenolone acetate is a steroid ester.
Manufacturing Process
8.42 ml of methyl iodide are slowly added dropwise at room temperature with
stirring in a nitrogen atmosphere to 3.067 g of magnesium turnings and 107
ml of absolute ether. After about 30 minutes, 185 ml of absolute
tetrahydrofuran are slowly introduced and then liquid is distilled off until a
boiling point of 62°C is reached. After cooling to room temperature, 613 mg
of cuprous chloride are added and then 10 g of ?1,4,6-androstatrien-17β-ol-3-
one-17-acetate in 110 ml of tetrahydrofuran slowly introduced. After 30
minutes reaction time, the whole is cooled to 0C, the excess of Grignard
reagent decomposed with saturated ammonium chloride solution, the product
diluted with ether and the aqueous phase separated. The ethereal phase is
washed consecutively with aqueous sodium thiosulfate solution, saturated
ammonium chloride solution and water. It is dried over sodium sulfate and
evaporated to dryness under vacuum. The residue is dissolved in 40 ml of
pyridine and 20 ml of acetic anhydride and the solution kept for 16 hours at
room temperature. It is then stirred into ice water and the precipitate filtered
with suction, dried and recrystallized from isopropyl ether. 1α-Methyl-?4,6-
androstadien-17β-ol-3-one-17-acetate is obtained. MP 156°C to 157°C; [α]D25
= -33.8° (in CHCl3; c = 0.9). Yield 65-70% of the theoretical.
4.67 g of 1α-methyl-?4,6-androstadien-17β-ol-3-one-17-acetate are dissolved
in 273 ml of methanol and, after the addition of 350 mg of 10% palladium on
calcium carbonate catalyst, hydrogenated until 1 mol equivalent of hydrogen
has been taken up. After filtering off the catalyst, the solution is treated with
150 ml of 2N-hydrochloric acid and evaporated under vacuum to about 1/3 of
the volume. The whole is then diluted with water and extracted with ether.
The ethereal solution is washed with water until neutral, dried over sodium
sulfate and evaporated. The crude product is heated on a steam bath for 90
minutes in 10 ml of pyridine and 10 ml of acetic anhydride. Extraction with
ether is then carried out and the ethereal phase washed until neutral with
water. The crude crystalline 1α-methyl-?4-androsten-17β-ol-3-one-17-
acetateobtained after drying and evaporation of the solution, melts at 122°C
to 129°C. Yield 98% of the theoretical.
1α-Methyl-?4-androsten-17β-ol-3-one-17-acetate when purified by
recrystallization from isopropyl ether melts at 138°C to 139°C.
Therapeutic Function
17β-Hydroxy-1β-methyl-5α-androst-l-ene-3-one acetate
References
Ho, Emmie N. M., et al. "Metabolic studies of methenolone acetate in horses." Analytica Chimica Acta 540.1(2005): 111-119.
https://en.wikipedia.org/wiki/Metenolone_acetate
Methenolone acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | ada@sh-teruiop.com | China | 893 | 58 |
| Wuhan Golt Biotech Co., Ltd. | +8615389281203 | maria@goltbiotech.com | China | 980 | 58 |
| Wuhan Demeikai Biotechnology Co., Ltd | +8618942921723 | info@dmksw.xin | China | 723 | 58 |
| Hubei Lange Biotechnology Co., Ltd. | +8617762501948 | sales2@langebiotech.com | China | 154 | 58 |
| Hebei Gongyuan New Material Technology Co., Ltd. | +8617331136198 | Grace@hebeisyjl.com | China | 497 | 58 |
| Hebei Yinsheng Technology Co., Ltd. | +86-17331136691 | lemon@hbyinsheng.com | China | 622 | 58 |
| Hebei Shengyuan Jinlong Import and Export Co. LTD | +8617367750398 | info@hebeisyjl.com | China | 1867 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 204 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
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View Lastest Price from Methenolone acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | Methenolone Acetate
434-05-9
|
US $1.00 / g | 1g | 99% | 20tons | Shanghai Longyu Biotechnology Co., Ltd. | |
 |
2024-04-25 | Methenolone Acetate
434-05-9
|
US $11.00-90.00 / kg | 0.10000000149011612kg | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-25 | Metenolone Acetate
434-05-9
|
US $200.00-100.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD |
-
- Methenolone Acetate
434-05-9
- US $1.00 / g
- 99%
- Shanghai Longyu Biotechnology Co., Ltd.
-
- Methenolone Acetate
434-05-9
- US $11.00-90.00 / kg
- 99%
- Hebei Kangcang new material Technology Co., LTD
-
- Metenolone Acetate
434-05-9
- US $200.00-100.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD