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L-(+)-Ergothioneine

L-(+)-Ergothioneine Structure
L-(+)-Ergothioneine structure
CAS No.
497-30-3
Chemical Name:
L-(+)-Ergothioneine
Synonyms
ERGOTHIONEINE;L-ERGOTHIONEINE;Ergothionine;Erythrothioneine;L-Ergothioneine(EGT);ERGOLD;THIONEINE;2-MERCAPTOHISTIDINE BETAINE;L-Ergothioneine, 2-thio-imidazole;(S)-[1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethylammonium hydroxide
CBNumber:
CB8460398
Molecular Formula:
C9H15N3O2S
Molecular Weight:
229.3
MDL Number:
MFCD00167474
MOL File:
497-30-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-04 11:17:55
Product description Number Pack Size Price
L-(+)-Ergothioneine E7521 5mg $299
L-(+)-Ergothioneine E7521 25mg $1280
L-(+)-Ergothioneine ≥98% 14905 5mg $69
L-(+)-Ergothioneine ≥98% 14905 10mg $127
L-(+)-Ergothioneine ≥98% 14905 25mg $280
More product size
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L-(+)-Ergothioneine Properties

Melting point 275-277°C (dec.)
Density 1.2541 (rough estimate)
refractive index 1.6740 (estimate)
storage temp. -20°C
solubility Soluble in Water (up to 10 mg/ml)
form White solid.
pka 1.706±0.32(predicted)
color White or off-white
PH +47^o (c=1 in water)
biological source fungus (Actinomycetales)
fungus (Ascomycota)
fungus (Basidiomycota)
Water Solubility water: 50mg/mL, clear, colorless
Stability Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for no more then 1 day.
Cosmetics Ingredients Functions SKIN CONDITIONING - MISCELLANEOUS
ANTIOXIDANT
InChI InChI=1/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/s3
InChIKey SSISHJJTAXXQAX-KPOCXSGKNA-N
SMILES [N+](C)(C)(C)[C@@H](CC1=CNC(S)=N1)C([O-])=O |&1:4,r|
FDA UNII BDZ3DQM98W
EPA Substance Registry System 1H-Imidazole-4-ethanaminium, .alpha.-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (.alpha.S)- (497-30-3)
UNSPSC Code 12352209
NACRES NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352-P304+P340
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
HS Code  2933299090
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

L-(+)-Ergothioneine price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E7521 L-(+)-Ergothioneine 497-30-3 5mg $299 2026-04-30 Buy
Sigma-Aldrich E7521 L-(+)-Ergothioneine 497-30-3 25mg $1280 2026-04-30 Buy
Cayman Chemical 14905 L-(+)-Ergothioneine ≥98% 497-30-3 5mg $69 2026-04-30 Buy
Cayman Chemical 14905 L-(+)-Ergothioneine ≥98% 497-30-3 10mg $127 2026-04-30 Buy
Cayman Chemical 14905 L-(+)-Ergothioneine ≥98% 497-30-3 25mg $280 2026-04-30 Buy
Product number Packaging Price Buy
E7521 5mg $299 Buy
E7521 25mg $1280 Buy
14905 5mg $69 Buy
14905 10mg $127 Buy
14905 25mg $280 Buy

L-(+)-Ergothioneine Chemical Properties,Uses,Production

Description

L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine via hercynine. Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression. In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine. Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.

Chemical Properties

White Solid

Uses

L-(+)-Ergothioneine is a natural molecule isolated from the rye ergot fungus and later identified in rat erythrocytes and liver and in numerous other animal tissues. Its antioxidizing properties may afford the compound therapeutic potential or it may be used as a food additive or in cosmetics.

Definition

ChEBI: Ergothioneine is a L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine synthesized by bacteria and fungi with antioxidant properties. It is found ubiquitously in plants and animals and is present in many human foodstuffs. It has a role as an antioxidant, a fungal metabolite, a plant metabolite, a xenobiotic metabolite and a chelator. It is an amino-acid betaine, a L-histidine derivative and a sulfur-containing amino acid. It is a conjugate base of an ergothioneine(1+). It is a tautomer of an ergothioneine thione form.

Origin

Ergothioneine was discovered in 1909 by Charles Tanret, a French pharmacist and chemist. Tanret was examining the ergot fungus, which had recently been responsible for destroying crops, and he discovered the compound by using a purification process. The amino acid name ergothioneine originates from this fungus. Though this discovery is relatively recent, scientists speculate that ergothioneine may have originated from ancient earth. Due to its anaerobic nature (it does not require oxygen to function), it may have manifested in the earth's oxygen-free atmosphere more than three billion years ago While ergothioneine is not classified as one of the nine essential amino acids.

benefits

L-(+)-Ergothioneine is a natural antioxidant, which has various physiological functions such as scavenging free radicals, detoxification, maintaining DNA biosynthesis, normal cell growth and cellular immunity.

General Description

L-(+)-Ergothioneine (ERG)  is a substance that cannot be synthesized by humans and must be obtained from food. It has cytoprotective and antioxidant properties.

Source

L-(+)-Ergothioneine (ET) is a sulfur-containing amino acid, which is only produced by Actinomycetales bacteria and non-yeast like fungi belonging to the division Basidiomycota and Ascomycota. It was originally isolated from Claviceps purpurea or rye ergot. It is obtained from L-histidine, which is converted into betaine form called hercynine. It is found in both animals and plants, and mammals usually obtain it from their diet, e.g. through mushrooms or oats. It is tautomeric in nature, and in neutral aqueous solution exists in thione form.
L-( )-Ergothioneine

Biochem/physiol Actions

L-(+)-Ergothioneine (ET) has the maximum concentrations in tissues subjected to oxidative stress, with the highest being in blood, eye lens, bone marrow, semen and liver. It acts as an anti-oxidant and prevents apoptosis, by scavenging reactive oxygen and nitrogen species. The anti-oxidant activity is attributable to sulfhydryl groups. It acts as a substrate for SLC22A4 (solute carrier family 22, member 4) transporter. In alveolar macrophages, it prevents the release of interleukin-8 (IL-8) by tumor necrosis factor (TNF)α. IL-8 is an inflammatory cytokine. It also regulates the oxidative damage in liver and kidneys, and has a protective action against lipid peroxidation. It is also responsible for the conservation of endogenous glutathione and α-tocopherol. ET being an antioxidant, protects against γ and UV radiation. In UV-irradiated human dermal fibroblasts, it scavenges reactive oxygen species (ROS), and suppresses matrix metalloproteinases 1 (MMP1) expression. It might also have anti-ageing effects on skin caused by UV-radiation.

Side effects

L-(+)-Ergothioneine is likely safe when used in amounts found in foods. There isn't enough reliable information to know if ergothioneine is safe when used in larger amounts as medicine, or what the side effects might be.

Synthesis

L-(+)-Ergothioneine is prepared by the reaction of hercynine. The steps are as follows:
15g of compound was added to 150ml of water, and 15.6g of concentrated hydrochloric acid was added, add 10.9g dibromohydantoin, stir for 20min, add D-cysteine, Continue to stir for 1 hour, add sodium thiosulfate, raise the temperature to 90-100°C, and continue the reaction for 15 hours. After the reaction, cool down and filter, adjust the pH to neutral, desalt, concentrate, crystallize with 5ml of water and 75ml of isopropanol, and dissolve the solid Filter and dry at 70-80°C to obtain 88% ergothioneine product with a yield of 81%.
L-(+)-Ergothioneine synthesis

Production Methods

The synthesis of L-(+)-Ergothioneine can be performed in water and includes the following steps. First, l-hercynine is reacted with bromine and then with cysteine. The intermediate obtained is transformed into ET by heating in the presence of mercaptopropionic acid. Finally, the raw product is purified by crystallisation.

References

[1] Williamson R, et al. L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model. Hypertension , 2022; 75. DOI:10.1161/HYPERTENSIONAHA.119.13929
[2] Hoek S, et al. Engineering the Yeast Saccharomyces cerevisiae for the Production of L-(+)-Ergothioneine. Frontiers in Bioengineering and Biotechnology, 2019. DOI:10.3389/fbioe.2019.00262

L-(+)-Ergothioneine Preparation Products And Raw materials

Raw materials

Preparation Products

L-(+)-Ergothioneine Suppliers

Global( 556)Suppliers
Supplier Tel Email Country ProdList Advantage
Maintain Biotech Co., Ltd. 		+86-75589664337 +86-15112661142 cami@maintain-bio.com China 97 58
Huzhou Haipu Chemical Co.,Ltd 		+86-0572 2526078; +86-13757061525 xatyang@acetylacetone.net China 26 58
Sinoway Industrial co., ltd. 		+86-0592-5800732 +86-13806035118 xie@china-sinoway.com China 1366 58
Chemsigma International Co., Ltd.
+86-2558742998 +86-19951791336 info@chemsigma.com China 1823 58
GIHI CHEMICALS CO.,LIMITED
+86-571-86217390; +8618058761490 info@gihichemicals.com China 49859 58
Shangdong Yuanlitai Nutratech Co.,ltd
18782242822 tatiana@yltnutra.com China 8 58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)
+86-57182358004 +86-13588810720 sales1@weitai-pharmaceutical.com France 71 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd.
+86-13119157289; +86-13119157289 13119157289@163.com China 999 58
Hangzhou Lucky Biology Co., Ltd
+8618105713381 lucky@lkbiology.com China 174 58
Improve Medical Technology(Nanxiong) Co.,Ltd
+86-13711621707 Jimin211@foxmail.com China 21 58
Supplier Advantage
Maintain Biotech Co., Ltd. 		58
Huzhou Haipu Chemical Co.,Ltd 		58
Sinoway Industrial co., ltd. 		58
Chemsigma International Co., Ltd.
58
GIHI CHEMICALS CO.,LIMITED
58
Shangdong Yuanlitai Nutratech Co.,ltd
58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)
58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd.
58
Hangzhou Lucky Biology Co., Ltd
58
Improve Medical Technology(Nanxiong) Co.,Ltd
58

Related articles

Related Qustion

Ask a question
Q:What is the optimal dose of L-(+)-Ergothioneine?Walter - Dec 22，2025
A:The most commonly used L-Ergothioneine dose in supplements ranges between 5 and 10 mg per day, with some products offering up to 20–30 mg. Human studies so far have used doses between 5 and 25 mg daily without reporting adverse effects. While these amounts seem sufficient to support antioxidant activity and cellular protection, there is currently no established daily requirement, and the optimal dose likely depends on individual factors such as age, diet, and health status.
Q:Which foods contain higher levels of L-(+)-ergothioneine?Anonymous - Aug 29，2025
A:L-(+)-Ergothioneine is an amino acid derivative possessing potent antioxidant activity, obtainable from natural food sources. Mushrooms exhibit the highest L-(+)-Ergothioneine content, ranging approximately from 2.4 to 4.9 milligrams, primarily found in King oyster, maitake, oyster, and shiitake varieties. Additionally, it is present in certain soy products and grains, such as black beans, red beans, and oat bran. The antioxidant properties of L-(+)-Ergothioneine enable it to mitigate oxidative stress damage to sperm and ova, thereby enhancing fertility. Subsequent in vivo and in vitro experiments have corroborated this finding.

View Lastest Price from L-(+)-Ergothioneine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-(+)-ergothioneine pictures 2026-08-15 L-(+)-ergothioneine
497-30-3
 1kg 0.99 20tons HANGZHOU INVERTIN BIOPHARMA CO., LTD.
L-Ergothioneine pictures 2026-08-15 L-Ergothioneine
497-30-3
 $10.00 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
L-Ergothioneine pictures 2026-08-14 L-Ergothioneine
497-30-3
 $79.00-949.00 1g 0.99 25kg Shanghai UCHEM Inc.

L-(+)-Ergothioneine Spectrum

L-(+)-Ergothioneine(497-30-3)1HNMR

497-30-3(L-(+)-Ergothioneine)Related Search:

Hydroxytyrosol Acetate Apigenin Delphinidin chloride Luteolin Angoroside C
Nordihydroguaiaretic acid Quercetin dihydrate U-83836E L-(+)-ERGOTHIONEINE ERGOTHIONEINE
L-(+)-Ergothioneine Betaine 2-MERCAPTO-L-HISTIDINE N,N-DIMETHYL-HIS-OH Ergothioneine hydrochloride
ERGOTHIONEINE, [3H]- D-Ergothioneine dihydrate N,N-dimethylhistamine

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L-(+)-ERGOTHIONEINE INNER SALT 1H-Imidazole-4-ethanaminium, .alpha.-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (.alpha.S)- 3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-trimethylammonio-propanoate (S)-alpha-Carboxy-2,3-dihydro-N,N,N-tri 2-Mercaptohistidine trimethylbetaine 2-Mercapto-N,N-dimethylhistidine methyl ester betaine Thiolhistidine betaine (αS)-α-Carboxy-2,3-dihydro-N,N,N-triMethyl-2-thioxo-1H-iMidazole-4-ethanaMiniuM Inner Salt NSC 7175 SyMpectothion Thiasine Thiotane Phytothioneine thiotaine L-(+)-ERGOTHIONEINE 1H-Imidazole-4-ethanaminium, α-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (αS)- Liposomal Ergothioneine Armillaria Matsutake Extract ergothioneine，EGT top quality Ergothioneine L-(+)-ERGOTHIONEINE USP/EP/BP (S)-3-(2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)propanoate Ergothiaine 1H-Imidazole-4-ethanaminium,a-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-,inner salt, (aS)- ERGOLD 2-MERCAPTOHISTIDINE BETAINE (S)-ALPHA-CARBOXY-2,3-DIHYDRO-N,N,N-TRIMETHYL-2-THIOXO-1H-IMIDAZOLE-4-ETHANAMINIUM INNER SALT THIONEINE (S)-[1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethylammonium hydroxide Ergothioneine 99% (S)-[1-carboxy-2-(2-mercaptoimidazol-4-yl)etChemicalbookhyl]trimethylammoniumhydroxide Ergotin Pleurotus citrinopileatus extract ergotin ERGOTHIONEINE INNER SALT Ergothione Pleurotus citrinopileatus extract Ergothioneine High quality Ergothioneine 99% powder Natural Ergothioneine / EGT Ergothioneine（Food grade） Golden Oyster Mushroom Extract L-Ergothioneine Cosmetic Grade Raw Powder Adenosine Impurity 16（2’-Deoxyguanosine Monomer） Cosmetic/Food Grade L-(+)-Ergothioneine 2-thio-imidazole AntiOxd-Ex Ergothioneinum Oil-Soluble ERGOTHIONEINE (S)-3-(2-thio-2,3-dihydro-1H-imidazole-4-yl)-2-(trimethyl)propanoic acidester Golden Oyster Mushroom Extract Powder L-Ergothioneine/Ergothioneine Ergothioneine (Standard) Ergothionine ERGOTHIONEINE Erythrothioneine L-Ergothioneine, 2-thio-imidazole L-Ergothioneine(EGT) L-ERGOTHIONEINE Liposomal L-Ergothioneine