ChemicalBook
Chinese Japanese Germany Korea

Prostaglandin E2

Prostaglandin E2
Prostaglandin E2 structure
CAS No.
363-24-6
Chemical Name:
Prostaglandin E2
Synonyms
PGE2;l-pge2;prostin;Propess;U 12062;Cervidil;Prepidil;prostine2;Prostenon;Cerviprost
CBNumber:
CB8461799
Molecular Formula:
C20H32O5
Formula Weight:
352.47
MOL File:
363-24-6.mol

Prostaglandin E2 Properties

Melting point:
66-68 °C
alpha 
-85.5 º (c=1, C2H5OH)
Boiling point:
406.07°C (rough estimate)
Density 
1.0601 (rough estimate)
refractive index 
1.6120 (estimate)
storage temp. 
-20°C
solubility 
ethanol: 1 mg/mL
pka
pKa 4.77± 0.09(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain)
form 
powder
color 
Clear yellow to amber
Water Solubility 
insoluble
Merck 
14,7877
BRN 
4709356
InChIKey
XEYBRNLFEZDVAW-ARSRFYASSA-N
CAS DataBase Reference
363-24-6(CAS DataBase Reference)
FDA UNII
K7Q1JQR04M
NCI Dictionary of Cancer Terms
prostaglandin
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H360
Precautionary statements  P201-P308+P313-P280-P301+P312+P330
Hazard Codes  T
Risk Statements  60-22-61
Safety Statements  53-22-26-36/37/39-45
WGK Germany  3
RTECS  UK8000000
8-10
HS Code  29375000

Prostaglandin E2 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 538904 Prostaglandin E? 363-24-6 1mg $97.12 2021-03-22 Buy
Sigma-Aldrich D2250000 Dinoprostone European Pharmacopoeia (EP) Reference Standard 363-24-6 $190 2021-03-22 Buy
Sigma-Aldrich BP902 Dinoprostone British Pharmacopoeia (BP) Reference Standard 363-24-6 $220 2021-03-22 Buy
Sigma-Aldrich 1213103 Dinoprostone United States Pharmacopeia (USP) Reference Standard 363-24-6 125mg $3550 2021-03-22 Buy
TCI Chemical P1884 Prostaglandin E2 >98.0%(HPLC) 363-24-6 1mg $63 2021-03-22 Buy

Prostaglandin E2 Chemical Properties,Uses,Production

Chemical Properties

White to pale yellowish-cream powder

Originator

Prostin E2,Upjohn,UK,1972

Uses

The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient.

Definition

ChEBI: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostagland ns.

Manufacturing Process

Hexamethyldisilazane (1 ml) and trimethylchlorosilane (0.2 ml) are added with stirring to a solution of PGA2 (250 mg) in 4 ml of tetrahydrofuran at 0°C under nitrogen. This mixture is maintained at 5°C for 15 hours. The mixture is then evaporated under reduced pressure. Toluene is added and evaporated twice. Then the residue is dissolved in 6 ml of methanol, and the solution is cooled to -20°C. Hydrogen peroxide (0.45 ml; 30% aqueous) is added. Then, 1N sodium hydroxide solution (0.9 ml) is added dropwise with stirring at - 20°C. After 2 hours at -20°C, an additional 0.3 ml of the sodium hydroxide solution is added with stirring at -20°C. After another hour in the range -10°C to -20°C, an additional 0.1 ml of the sodium hydroxide solution is added. Then, 1.5 ml of 1 N hydrochloric acid is added, and the mixture is evaporated under reduced pressure. The residue is extracted with ethyl acetate, and the extract is washed successively with 1 N hydrochloric acid and
ine, dried with anhydrous sodium sulfate and evaporated. The residue is dissolved in 5 ml of diethyl ether. To this solution is added 0.5 ml of methanol and 0.1 ml of water. Amalgamated aluminum made from 0.5 g of aluminum metal is then added in small portions during 3 hours at 25°C. Then, ethyl acetate and 3 N hydrochloric acid are added, and the ethyl acetate layer is separated and washed successively with 1 N hydrochloric acid and
ine, dried with anhydrous sodium sulfate, and evaporated. The residue is chromatographed on 50 g of acid-washed silica gel, eluting first with 400 ml of a gradient of 50- 100% ethyl acetate in Skellysolve B, and then with 100 ml of 5% methanol in ethyl acetate, collecting 25 ml fractions. Fractions 9 and 10 are combined and evaporated to give 18 mg of 11β-PGE2. Fractions 17-25 are combined and evaporated to give 39 mg of PGE2.

brand name

Cervidil (Controlled Therapeutics); Prepidil (Pharmacia & Upjohn); Prostin E2 (Pharmacia & Upjohn);Minprostin;Prostaglandin;Prostarmon e;Prostin vr pediatric.

Therapeutic Function

Oxytocic, Abortifacient

World Health Organization (WHO)

Dinoprostone, prostaglandin E2, was introduced into medicine in 1971 and is primarily used for cervical ripening during the induction of labour. It is available in various formulations for oral, parenteral and vaginal administration. Tablets, ampoules and vaginal dosage forms (tablets, pessaries, gel) remain registered in many countries.

General Description

PGE2 Dinoprostone (Prostin E2;Cervidil) is a naturally occurring prostaglandin that is administeredin a single dose of 10 mg by controlled-release(0.3 mg/hr) vaginal insert to induce cervical ripening. Use ofthis agent will potentiate the effects of oxytocin.

Biological Activity

Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP 1 , EP 2 , EP 3 and EP 4 receptors (K d values range between ~ 1-10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.

Safety Profile

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by intravenous, intraplacental, and intravaginal routes: changes in the uterus, cervix and vagina; termination of pregnancy; and changes in ferthty. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Prostaglandin E2 Preparation Products And Raw materials

Raw materials

Preparation Products


Prostaglandin E2 Suppliers

Global( 231)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai finete Pharmaceutical Co., Ltd.
+86-18221039705
- sales@finetechpharm.com CHINA 139 55
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58

View Lastest Price from Prostaglandin E2 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-14 Prostaglandin E2
363-24-6
US $317.00 / g 1g 99% 1KG Baoji Guokang Healthchem co.,ltd
2021-07-13 Prostaglandin E2
363-24-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Prostaglandin E2
363-24-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

363-24-6(Prostaglandin E2 )Related Search:


Copyright 2017 © ChemicalBook. All rights reserved