ChemicalBook >> CAS DataBase List >>Propylphosphonic anhydride
Propylphosphonic anhydride
- CAS No.
- 68957-94-8
- Chemical Name:
- Propylphosphonic anhydride
- Synonyms
- T3P;1-PROPANEPHOSPHONIC ANHYDRIDE;PPACA;1-PROPANEPHOSPHONIC ACID CYCLIC ANHYDRIDE;PROPANE PHOSPHONIC ACID ANHYDRIDE;1-PROPYLPHOSPHONIC ACID CYCLIC ANHYDRIDE;2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide;PPAA;Propylphosphonic acid anhydride;T3P/Propanephosphonic acid cyclic anhydride
- CBNumber:
- CB8462554
- Molecular Formula:
- C9H21O6P3
- Molecular Weight:
- 318.18
- MDL Number:
- MFCD00006583
- MOL File:
- 68957-94-8.mol
- MSDS File:
- SDS
Last updated:2023-05-15 10:43:35
| Boiling point | 65 °C |
|---|---|
| Density | 1.069 g/mL at 25 °C |
| vapor pressure | 0Pa at 25℃ |
| refractive index |
n |
| Flash point | 25 °F |
| storage temp. | Flammables area |
| solubility | Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents. |
| form | Solution |
| color | Clear yellow to brownish |
| Water Solubility | 9.6g/L at 25℃ |
| Sensitive | Moisture Sensitive |
| BRN | 5079255 |
| Exposure limits |
ACGIH: TWA 20 ppm (Skin) OSHA: TWA 40 ppm(70 mg/m3) NIOSH: IDLH 137 ppm(25 mg/m3); TWA 20 ppm(34 mg/m3) |
| Stability | Moisture Sensitive |
| LogP | 0 at 25℃ |
| CAS DataBase Reference | 68957-94-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | I6EGD8839N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H290-H314-H336 | |||||||||
| Precautionary statements | P210-P233-P234-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | T,C,F | |||||||||
| Risk Statements | 61-20/21-34-67-66-11 | |||||||||
| Safety Statements | 53-26-36/37/39-45-33-16 | |||||||||
| RIDADR | UN 2924 3/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| F | 21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29319019 | |||||||||
| NFPA 704 |
|
Propylphosphonic anhydride Chemical Properties,Uses,Production
Reaction
- TP3 is an exceptional reagent for amide/peptide bond formation. The product is very easy to use and combines excellent reaction selectivity, low epimerization, high yields and high product purities.
- Conversions of acids and amides to nitriles under mild conditions.
- Synthesis of urea and carbamate derivatives.
- Formation of thioacids from N-protected amino acids and peptides.
Chemical Properties
Clear light yellow solution
Uses
Propylphosphonic anhydride may be used in the following studies:
- As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
- Microwave-assissted Fischer indolization of arylhydrazines.
- As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
- One-pot synthesis of coumarins.
- Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
- One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
- Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.
Uses
It is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.
General Description
Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low toxic coupling agent used in peptide synthesis. T3P also acts as a promoter and water scavenger in the Friedl?nder annulation reaction. It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and C-C coupling reactions. T3P delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.
Flammability and Explosibility
Not classified
Propylphosphonic anhydride Preparation Products And Raw materials
68957-94-8(Propylphosphonic anhydride)Related Search:
1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in dichloroMethane
1-Propylphosphonic acid cyclic anhydride, 50 wt.% solution in ethyl acetate
1-Propylphosphonic anhydride solution, 50 wt. % in DMF
1-Propylphosphonic anhydride solution, 50 wt. % in ethyl acetate
2,4,6-tripropyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinane 2,4,6-trioxide
2,4,6-Tripropyl-1,3,5,2,4,6-trioxotriphosphorinane-2,4,6-trioxide (50% solution in Ethyl aceta
1-Propanephosphonic anhydride, in 50% DMF solution≥ 95%
2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution
2,4,6-TRIPROPYL-1,3,5,2,4,6-TRIOXATRIPHOSPHORINE-2,4,6-TRIOXIDE
2,4,6-Tripropyl-1,3,5-trioxa-2,4,6-triphosphacyclohexane 2,4,6-trioxide
2,4,6-Tripropyl-2,4,6-triphospha-1,3,5-trioxacyclohexane 2,4,6-trioxide
1,3,5,2,4,6-trioxatriphosphorinane
1-Propanephosphonic acid cyclic anhydride 50% ethyl acetate
n-Propylphosphonic acid anhydride
Propylphosphonic acid cyclic anhydride
Propylphosphonic Anhydride Solution, 50% in Ethyl Acetate
Propylphosphonic anhydride solution technical, ~50% in DMF
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in dimethylformamide, AcroSeal
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in ethyl acetate, AcroSeal
propyl phoshonic anhydride
t3p (50% solution in etoac)
Propylphosphonic Anhydride Solution, 50wt.% in Ethyl Acetate
1-Propanephosphonic acid cyclic anhydride, 50 wt.% sol. in ethyl acetate 50ML
1-Propanephosphonic Acid Anhydride (Cyclic Trimer)
2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide
1,3,5,2,4,6-trioxatriphosphorinane,2,4,6-tripropyl-,2,4,6-trioxide
propanephosphonicacidanhydride(t3p)
propylphosphonicanhydridesolution
PROPYLPHOSPHONIC ACID ANHYDRIDE CYCLIC TRIMER
PROPYLPHOSPHONIC ANHYDRIDE
TRIS-N-PROPAN-PHOSPHONIC ACID ANHYDRIDE
Propylphosphonic anhydride solution technical,50% ethyl acetate
1-PROPANEPHOSPHONIC ACID ANHYDRIDE CYCLIC TRIMER
1-PROPYLPHOSPHONIC CYCLIC ANHYDRIDE
1-Propanephosphonic acid cyclic anhydride~(rgT3P~2,4,6-Tripropyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane
2,4,6-tripropyl-1,3,5-trioxa-2,4,6-triphosphorinane-2,4,6-trioxide
Propanephosphonic acid cyclic anhydride (T3P)
PROPYLPHOSPHONIC ANHYDRIDE SOLUTION, ~50 % IN DMF
PROPANEPHOSPHONIC ANHYDRIDE 50 % IN ETH&
1-Propanephosphonic acid cyclic anhydride, 50 wt.% sol. in ethyl acetate
1-propanephosphonic anhydride solution
1-PROPYLPHOSPHONIC ACID CYCLIC ANHYDRIDE: 50% SOLUTION IN DMF
TRIS-N-PROPAN-PHOSPHONIC ACID ANHYDRIDE: (50% IN DMF)
Propylphosphonic Acid Anhydride (Cyclic Trimer) (48% in N,N-Dimethylformamide, ca. 1.6mol/L)
Propylphosphonic Acid Anhydride (Cyclic Trimer) (50% in Ethyl Acetate, ca. 1.7mol/L)
tripropyl-1,3,5,2λ,4λ,6λ-trioxatriphosphinane-2,4,6-trione
1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF
2,4,6-tri-n-propyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane
1-Propanephosphonic anhydride solution, 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution
1-Propanephosphonic acid cyclic anhydride, 50 WT.% solution in dimethylformamide
1-PROPANEPHOSPHONIC ACID CYCLIC ANHYDRID E, 50 WT. % SOLUTION IN ETHYL ACETATE
PROPYLPHOSPHONIC ANHYDRIDE SOLUTION, ~50 % IN ETHYL ACET.
1-Propylphosphonicacidcyclicanhydride,50+%soln.inethylacetate
Propylphosphonic anhydride solution (50 wt.% in DMF)
4-[(R)-3-aminopiperidin-1-yl]-2-({6-[(R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl}methyl)benzonitrile, 4-((R)-3-aminopiperidin-1-yl)-2-((6-((R)-3-aminopiperidin-1-yl)-3-methyl-2,4-oxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Propylphosphonic anhydride 50% in EA
Propylphosphonic anhydride 50% in DMF
2,4,6-Tri-n-propyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane (Propylphosphonic acid anhydride 50% solution in N,N-dimethylformamide) T3P
2,4,6-Tripropyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane T3P (Propylphosphonic acid anhydride 50% solution in ethyl acetate)