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Geldanamycin

Geldanamycin
Geldanamycin structure
CAS No.
30562-34-6
Chemical Name:
Geldanamycin
Synonyms
GA;CS-503;CP-122634;nsc122750;NSC 212518;GeldanamyCln;GELDANAMYCIN;Geldanamycin>GELDANAMYCIN (GDM);GELDANAMYCIN, 99+%
CBNumber:
CB8462842
Molecular Formula:
C29H40N2O9
Formula Weight:
560.64
MOL File:
30562-34-6.mol

Geldanamycin Properties

Melting point:
255 °C
Boiling point:
627.87°C (rough estimate)
Density 
1.2443 (rough estimate)
refractive index 
1.5800 (estimate)
Flash point:
87℃
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
powder
pka
8.42±0.70(Predicted)
color 
yellow to orange
λmax
305nm(MeOH)(lit.)
CAS DataBase Reference
30562-34-6(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
Z3K3VJ16KU
SAFETY
  • Risk and Safety Statements
Hazard statements  H303-H227
Precautionary statements  P210e-P280a-P370+P378a-P403+P235-P501a
Hazard Codes  T,Xi
Risk Statements  36/37/38
Safety Statements  26-27-36/37/39-24/25
WGK Germany  2
RTECS  LX8920000
HS Code  29419090

Geldanamycin price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 345805 Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. 30562-34-6 100 μg $259.92 2021-12-16 Buy
Sigma-Aldrich 345805 Geldanamycin, A benzoquinoid antibiotic that inhibits p60 30562-34-6 100ug $271 2021-12-16 Buy
Sigma-Aldrich G3381 Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder 30562-34-6 1mg $593 2021-12-16 Buy
TCI Chemical G0334 Geldanamycin >98.0%(HPLC) 30562-34-6 10mg $287 2021-12-16 Buy
Alfa Aesar J67124 Geldanamycin, 1 mg/ml in DMSO, sterile-filtered 30562-34-6 1ml $280 2021-12-16 Buy

Geldanamycin Chemical Properties,Uses,Production

Description

Geldanamycin from Streptomyces hygroscopicus.
Geldanamycin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (Heat Shock Protein 90) and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the Hsp90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stress response.
Geldanamycin was found to be a potent antibiotic active at nanomolar concentrations against 60 cell lines as well as in mouse tumor models.
It is an inhibitor of proto-oncogenic protein kinases, such as erbB22, EFG receptor tyrosine kinases, and non-receptor tyrosine kinases, such as v-src and Raf-1. In addition, it is a potent inhibitor of the nuclear hormone receptor family including the estrogen and androgen hormone receptors.

Description

Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding. It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function. Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.

Chemical Properties

Yellow to Orange Powder

Uses

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Uses

Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. It is a potent antitumour metabolite that acts by binding to the 90-kDa heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase hTERT.

Uses

Geldanamycin?binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Definition

ChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.

General Description

Chemical structure: benzenoid

Biological Activity

Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.

Biochem/physiol Actions

Primary Targetpc60c-svc tyrosine kinase

Geldanamycin Preparation Products And Raw materials

Raw materials

Preparation Products


Geldanamycin Suppliers

Global( 254)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 376 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
whatsapp:+8613081092107 julia@hbshuoxi.com CHINA 973 58
Shaanxi Dideu Medichem Co. Ltd
15336106720
029-88380327 1017@dideu.com CHINA 3979 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Fuxin Pharmaceutical
021-50872116
contact@fuxinpharm.com CHINA 10305 58

View Lastest Price from Geldanamycin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-22 Geldanamycin
30562-34-6
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-17 geldanamycin 30562-34-6
30562-34-6
US $15.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-07-13 Geldanamycin
30562-34-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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