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C18 Ceramide-d3 (d18:1/18:0-d3)

CAS No.
2011762-82-4
Chemical Name:
C18 Ceramide-d3 (d18:1/18:0-d3)
Synonyms
C18 Ceramide-d3 (d18:1/18:0-d3);N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-d3]-octadecanamide
CBNumber:
CB84666080
Molecular Formula:
C36H71NO3
Molecular Weight:
565.97
MDL Number:
MFCD33024355
MOL File:
2011762-82-4.mol
Last updated:2023-05-21 10:59:17

C18 Ceramide-d3 (d18:1/18:0-d3) Properties

storage temp. Store at -20°C
solubility Chloroform: Soluble,DMF: Soluble,Ethanol: Warmed
form A solid

C18 Ceramide-d3 (d18:1/18:0-d3) price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24396 C18 Ceramide-d3 (d18:1/18:0-d3) ≥99% deuterated forms (d1-d3); ≤1% d0 2011762-82-4 1mg $426 2024-03-01 Buy
AK Scientific 1487EN 18,18,18-Trideuterio-N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]octadecanamide 2011762-82-4 1mg $826 2021-12-16 Buy
Product number Packaging Price Buy
24396 1mg $426 Buy
1487EN 1mg $826 Buy

C18 Ceramide-d3 (d18:1/18:0-d3) Chemical Properties,Uses,Production

Biological Activity

C18 Ceramide-d3 (d18:1/18:0) is intended for use as an internal standard for the quantification of C18 Ceramide (d18:1/18:0) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.1 Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.2 It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.3 [Matreya, LLC. Catalog No. 2201]

References

1.Mizutani, Y., Kihara, A., and Igarashi, Y.Mammalian Lass6 and its related family members regulate synthesis of specific ceramidesBiochem J.390(Pt. 1)263-271(2005) 2.Koybasi, S., Senkal, C.E., Sundararaj, K., et al.Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomasJ. Biol. Chem.279(43)44311-44319(2004) 3.Bergman, B.C., Brozinick, J.T., Strauss, A., et al.Muscle sphingolipids during rest and exercise: A C18:0 signature for insulin resistance in humansDiabetologia59(3)785-791(2016)

C18 Ceramide-d3 (d18:1/18:0-d3) Preparation Products And Raw materials

Raw materials

Preparation Products

C18 Ceramide-d3 (d18:1/18:0-d3) Suppliers

Global( 6)Suppliers
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Alfa Chemistry
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Yichang Zhongyitai Trading Co., Ltd. 0717-6449896 13886658719 root@zhongyitai.com China 1976 58
Alfa Chemistry 1-516-6625404 support@alfa-chemistry.com United States 9171 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
C18 Ceramide-d3 (d18:1/18:0-d3) N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-d3]-octadecanamide 2011762-82-4