Anti-BNIP3 antibody, Mouse monoclonal

CAS No.
Chemical Name:
Anti-BNIP3 antibody, Mouse monoclonal
Synonyms
Anti-BNIP3 antibody, Mouse monoclonal
CBNumber:
CB84669076
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

Anti-BNIP3 antibody, Mouse monoclonal Properties

storage temp. -20°C
form buffered aqueous solution

Anti-BNIP3 antibody, Mouse monoclonal price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B7931 Anti-BNIP3 antibody, Mouse monoclonal clone ANa40, purified from hybridoma cell culture 0.2mL $576 2024-03-01 Buy
Product number Packaging Price Buy
B7931 0.2mL $576 Buy

Anti-BNIP3 antibody, Mouse monoclonal Chemical Properties,Uses,Production

Uses

Rabbit monoclonal clone ANa40 anti-BNIP3 is used to tag BNIP3 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of BNIP3 in the regulation of mitochondrial and non-mitochondrial mediated apoptosis.

General Description

Monoclonal Anti-BNIP3 (mouse IgG2b isotype) is derived from the ANa40 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with a recombinant human BNIP3. B-cell lymphoma 2 (BCL2) Interacting Protein 3 (BNIP3) is a pro-apoptotic protein localized in mitochondria and belongs to Bcl-2 family. Its Bcl-2 homology 3 (BH3) domain is less conserved in mammalian cells and yeast.

Biochem/physiol Actions

B-cell lymphoma 2 (BCL2) Interacting Protein 3 (BNIP3) functions without a typical Bcl-2 homology 3 (BH3) domain. It interacts withcell death abnormality gene 9 (CED-9). BNIP3 interaction with B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-XL) regulates apoptosis in mitochondria l and non-mitochondrial sites. Endogenous BNIP3 is loosely associated with mitochondrial membrane in normal tissue but fully integrates into the mitochondrial outer membrane with the N-terminus in the cytoplasm and the C-terminus in the membrane during induction of cell death. This is accompanied by rapid and profound mitochondrial dysfunction characterized by opening of the mitochondrial permeability transition (PT) pore, proton electrochemical gradient (Dym) suppression, and increased reactive oxygen species production.

Anti-BNIP3 antibody, Mouse monoclonal Preparation Products And Raw materials

Raw materials

Preparation Products

Anti-BNIP3 antibody, Mouse monoclonal Suppliers

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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
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Anti-BNIP3 antibody, Mouse monoclonal