1-Methyl-1H-pyrazole-5-carboxylic acid
- CAS No.
- 16034-46-1
- Chemical Name:
- 1-Methyl-1H-pyrazole-5-carboxylic acid
- Synonyms
- SKL263;AKOS B000141;AKOS PAO-0505;CHEMBRDG-BB 4401287;ART-CHEM-BB B000141;TIMTEC-BB SBB000007;1-Methyl-1H-pyrazole-5-ca...;1-Methyl-pyrazole-5-carboxylicacid;2-Methylpyrazole-3-carboxylic acid;1-Methyl-5-pyrazolecarboxylic acid
- CBNumber:
- CB8467029
- Molecular Formula:
- C5H6N2O2
- Molecular Weight:
- 126.11
- MDL Number:
- MFCD00464253
- MOL File:
- 16034-46-1.mol
| Melting point | 220-225 °C |
|---|---|
| Boiling point | 306.9±15.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 3.03±0.25(Predicted) |
| color | White to Almost white |
| λmax | 259nm(MeOH)(lit.) |
| InChIKey | JREJQAWGQCMSIY-UHFFFAOYSA-N |
| CAS DataBase Reference | 16034-46-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29331990 | |||||||||
| NFPA 704 |
|
1-Methyl-1H-pyrazole-5-carboxylic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 722138 | 1-Methyl-1H-pyrazole-5-carboxylic acid 97% | 16034-46-1 | 1g | $197 | 2025-07-31 | Buy |
| TCI Chemical | M2494 | 1-Methylpyrazole-5-carboxylic Acid >97.0%(GC)(T) | 16034-46-1 | 1g | $31 | 2025-07-31 | Buy |
| TCI Chemical | M2494 | 1-Methylpyrazole-5-carboxylic Acid >97.0%(GC)(T) | 16034-46-1 | 5g | $90 | 2025-07-31 | Buy |
| TRC | M320925 | 1-Methyl-1H-pyrazole-5-carboxylic acid | 16034-46-1 | 50mg | $60 | 2021-12-16 | Buy |
| Apolloscientific | OR5218 | 1-Methyl-1H-pyrazole-5-carboxylic acid 97% | 16034-46-1 | 5g | $53 | 2021-12-16 | Buy |
1-Methyl-1H-pyrazole-5-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White to yellow solid
Uses
1-Methyl-5-pyrazolecarboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Definition
ChEBI: 1-methyl-pyrazole-5-carboxylic acid is a member of the class of pyrazoles that is N-methylpyrazole substituted by a carboxy group substituents at position 5. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It is functionally related to a N-methylpyrazole.
Synthesis
930-36-9
124-38-9
16034-46-1
1-Methyl-1H-pyrazole (2.0 g, 24.4 mmol) was dissolved in tetrahydrofuran (THF, 30 mL) at room temperature. The reaction mixture was cooled to -78 °C under nitrogen protection, followed by slow dropwise addition of n-butyllithium (n-BuLi, 10.72 mL, 26.8 mmol). The reaction temperature of -78 °C was maintained and the reaction mixture was stirred for 2 h. Subsequently, it was gradually warmed up to room temperature and stirring was continued for 1 h. The reaction temperature was maintained at -78 °C. Under the condition of maintaining the reaction temperature, dry carbon dioxide gas was passed into the reaction solution for about 5 minutes. The reaction mixture continued to be stirred at room temperature for 1 hour. Subsequently, water (30 mL) was added to the reaction mixture to quench the reaction and dilute the mixture. The reaction mixture was extracted with dichloromethane. After precipitation of a large amount of solid from the acidic aqueous phase, the separation was carried out by filtration. The resulting filter cake was dried to give a final 1.5 g of white solid product 1-methyl-1H-pyrazole-5-carboxylic acid in 48.8% yield.
References
[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 6, p. 650 - 654
[2] Patent: CN105384739, 2016, A. Location in patent: Paragraph 0345; 0346; 0347
[3] Patent: WO2009/71705, 2009, A1. Location in patent: Page/Page column 39
[4] Patent: WO2009/71706, 2009, A1. Location in patent: Page/Page column 48
[5] Patent: US2008/242661, 2008, A1. Location in patent: Page/Page column 25
1-Methyl-1H-pyrazole-5-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from 1-Methyl-1H-pyrazole-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-Methyl-1H-pyrazole-5-carboxylic acid
16034-46-1
|
US $1.00 / kg | 1kg | 98% | 200KG | Career Henan Chemical Co |
-
- 1-Methyl-1H-pyrazole-5-carboxylic acid
16034-46-1
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
