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Squalane

Occurrence Physical and chemical properties Squalane application Preparation Cooling Experiment
Squalane
Squalane structure
CAS No.
111-01-3
Chemical Name:
Squalane
Synonyms
Romane;ROBANE;Squalan;COSBIOL;Dermane;SQUALANE;SPINACANE;Vitabiosol;Squalane NF;Squalane,99%
CBNumber:
CB8469063
Molecular Formula:
C30H62
Formula Weight:
422.81
MOL File:
111-01-3.mol

Squalane Properties

Melting point:
−38 °C(lit.)
Boiling point:
176 °C0.05 mm Hg(lit.)
Density 
0.81 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.452(lit.)
Flash point:
424 °F
storage temp. 
room temp
solubility 
chloroform: soluble100mg/mL, clear
form 
neat
Water Solubility 
Not miscible or difficult to mix in water.
Merck 
14,8767
BRN 
776019
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
PRAKJMSDJKAYCZ-UHFFFAOYSA-N
CAS DataBase Reference
111-01-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
GW89575KF9
NIST Chemistry Reference
Tetracosane, 2,6,10,15,19,23-hexamethyl-(111-01-3)
EPA Substance Registry System
Squalane (111-01-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  XB6070000
TSCA  Yes
HS Code  29012990

Squalane price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 234311 Squalane 97% 111-01-3 5g $38.4 2019-12-02 Buy
Sigma-Aldrich 1619505 Squalane United States Pharmacopeia (USP) Reference Standard 111-01-3 500mg $384.65 2019-12-02 Buy
TCI Chemical H0096 Squalane >98.0%(GC) 111-01-3 25mL $16 2019-12-02 Buy
TCI Chemical H0096 Squalane >98.0%(GC) 111-01-3 100mL $39 2019-12-02 Buy
Alfa Aesar A17931 Squalane, 98% 111-01-3 100g $41 2019-12-02 Buy

Squalane Chemical Properties,Uses,Production

Occurrence

Squalane is obtained through the hydrogenation of squalene, and can be used as the oily raw materials of balsam, nutritional emulsion and other basic cosmetics. Squalene was obtained from the liver oil of Centrophorus or other deep-sea shark. Initially, it is the byproduct during the Vitamin A production process from shark liver oil. In recent years, it has been found that unsaponifiable oil of olive oil is rich in squalene, which can be used as the raw material of production of squalane (i.e., fully hydrogenated squalene).

Physical and chemical properties

Refined squalane is a colorless, odorless, inert and transparent oily viscous liquid. Slightly soluble in methanol, ethanol, acetone and glacial acetic acid. It is miscible with benzene, chloroform, carbon tetrachloride, petroleum ether, ether, mineral oil and other animal and vegetable oils. The relative density (15 °C/ 4 ℃) 0.812, refractive index (15 ℃) 1.4530, iodine value 0 ~ 5, saponification value 0 ~ 5, acid value 0 ~ 0.2, freezing point -38 ℃, boiling point 350 ℃. It is stable in the air, but can be slowly oxidized upon the action of sunlight. Sebaceous glands can synthesize squalene. Sebum contain squalene at a content of 1% in children and up to 10% in adult; sebum contains a squalane mass fraction of about 2%. Its permeability, lubricity and breathability is better than other fats, matching well with most cosmetic raw materials.

Squalane application

  1. Squalane is widely used as a cosmetic base and finishing cosmetics, precise machinery lubricants, perlite agent of medical ointment and advanced soap.
  2. Squalane is a natural product, being inert and non-toxic. It has good affinity to human skin without irritating the skin and causing allergies. It can accelerate the penetration of other actives into the skin. Squalane is a high-grade cosmetic oily raw materials, such as various types of creams and lotions, eyeliners, eyeshadow and conditioner. Cosmetics is mostly natural product extracted directly from cod liver oil. Synthetic products have stimulating effect on the human body, only used as lubricants and UV agents.
  3. Squalane is the most commonly used standard non-polar fixative with its polarity being set to zero. Such fixed liquid and component molecules is the dispersion force, mainly used for the separation of general hydrocarbons and non-polar compounds.

Preparation

  1. It can be refined directly from the cod liver oil with refinement the first vacuum decompression obtained crude squalane, and then in the nickel catalyst, high temperature, high pressure hydrogenation, remove the double bond part, and then vacuum distillation available.
  2. Synthesis method. Take isoprene as raw material; first apply chlorination of isoprene, generating methyl heptanone, followed by dehydrogenation to generate linalool; further apply linalool and geranyl acetone, finally generating squalane.
  3. Squalene can be used as raw material with direct hydrogenation to obtain it.
  4. Take olive oil as raw material, extract the squalene, and then perform hydrogenation to obtain it.
  5. Linalool can react with ethyl acetoacetate to generate 3, 7, 11-trimethyl-dodecane-6, 10-dien-1-yn-3-ol; further use cuprous oxide as a catalyst for oxidation and coupling, hydrogenation to obtain the finished product of squalane.

Cooling Experiment

This product at -55 ℃ without losing its liquidity. Test based on the freezing-point determination method. The thermometer used was a low flow point thermometer, glass bath D, and put into dry ice and acetone for cooling.

Chemical Properties

viscous colourless liquid

Uses

health foods

Uses

Squalane has been used: as solvent in the synthesis of Europium dibenzoylmethide triethylammonium, brightest known triboluminescent (TL) material;as lubricant for fatty acid surfactant films adsorbed on iron oxide surfaces

Uses

Lubricant, transformer oil. Ingredient of watch and chronometer oils. Perfume fixative. In pharmacy and cosmetics as skin lubricant, ingredient of suppositories, carrier of lipid-soluble drugs.

Uses

squalane is an excellent moisturizer and lubricant, it softens and smoothes the skin while also replenishing skin lipids. Its compatibility with skin lipids can be attributed to the fact that human sebum is made up of 25 percent squalane. Squalane has traditionally been obtained by hydrogenation of shark liver oil or other natural oils. Components found in fish oils may reduce skin irritation and allergic responses. It can also be derived from plant sources or synthetically manufactured.

Definition

A saturated hydrocarbon.

Purification Methods

Purify squalane by fractional distillation in vacuo or evaporative distillation. It is soluble in pet ether, *C6H6, Et2O and CHCl3, slightly soluble in alcohols, Me2CO and AcOH but insoluble in H2O. Small quantities can be purified by TLC as for squalene below. It is used as a marker in GLC and HPLC. [Staudinger & Leupold Helv Chim Acta 15 223 1932, Sax & Stross Anal Chem 29 1700 1951, Mandai et al. Tetrahedron Lett 22 763 1981, Beilstein 1 IV 593.]

Squalane Preparation Products And Raw materials

Raw materials

Preparation Products


Squalane Suppliers

Global( 191)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2995 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 4895 58
Haihang Industry Co.,Ltd
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+86 531 8582 1093 export@haihangchem.com CHINA 10229 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
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86-21-51086038
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Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28235 58

View Lastest Price from Squalane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-10 Squalane
111-01-3
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2019-08-30 Squalane
111-01-3
US $1.00 / KG 1KG ≥98% 200kg career henan chemical co

Squalane Spectrum


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