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Occurrence Physical and chemical properties Squalane application Preparation Cooling Experiment
Squalane structure
Chemical Name:
ROBANE;Romane;Dermane;COSBIOL;Squalan;SQUALANE;SPINACANE;Vitabiosol;Squalane NF;Squalane>
Molecular Formula:
Formula Weight:
MOL File:

Squalane Properties

Melting point:
−38 °C(lit.)
Boiling point:
176 °C0.05 mm Hg(lit.)
0.81 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.452(lit.)
Flash point:
424 °F
storage temp. 
room temp
chloroform: soluble100mg/mL, clear
Water Solubility 
Not miscible or difficult to mix in water.
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
111-01-3(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Tetracosane, 2,6,10,15,19,23-hexamethyl-(111-01-3)
EPA Substance Registry System
Squalane (111-01-3)
  • Risk and Safety Statements
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  XB6070000
HS Code  29012990

Squalane price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 442784 Squalane analytical standard 1000 mg $21.6 2021-03-22 Buy
Sigma-Aldrich 234311 Squalane 97% 111-01-3 5g $39.4 2020-08-18 Buy
Sigma-Aldrich Y0000185 Squalane European Pharmacopoeia (EP) Reference Standard $190 2021-03-22 Buy
Sigma-Aldrich 1619505 Squalane United States Pharmacopeia (USP) Reference Standard 111-01-3 500mg $399 2021-03-22 Buy
TCI Chemical H0096 Squalane >98.0%(GC) 111-01-3 25mL $17 2021-03-22 Buy

Squalane Chemical Properties,Uses,Production


Squalane is obtained through the hydrogenation of squalene, and can be used as the oily raw materials of balsam, nutritional emulsion and other basic cosmetics. Squalene was obtained from the liver oil of Centrophorus or other deep-sea shark. Initially, it is the byproduct during the Vitamin A production process from shark liver oil. In recent years, it has been found that unsaponifiable oil of olive oil is rich in squalene, which can be used as the raw material of production of squalane (i.e., fully hydrogenated squalene).

Physical and chemical properties

Refined squalane is a colorless, odorless, inert and transparent oily viscous liquid. Slightly soluble in methanol, ethanol, acetone and glacial acetic acid. It is miscible with benzene, chloroform, carbon tetrachloride, petroleum ether, ether, mineral oil and other animal and vegetable oils. The relative density (15 °C/ 4 ℃) 0.812, refractive index (15 ℃) 1.4530, iodine value 0 ~ 5, saponification value 0 ~ 5, acid value 0 ~ 0.2, freezing point -38 ℃, boiling point 350 ℃. It is stable in the air, but can be slowly oxidized upon the action of sunlight. Sebaceous glands can synthesize squalene. Sebum contain squalene at a content of 1% in children and up to 10% in adult; sebum contains a squalane mass fraction of about 2%. Its permeability, lubricity and breathability is better than other fats, matching well with most cosmetic raw materials.

Squalane application

  1. Squalane is widely used as a cosmetic base and finishing cosmetics, precise machinery lubricants, perlite agent of medical ointment and advanced soap.
  2. Squalane is a natural product, being inert and non-toxic. It has good affinity to human skin without irritating the skin and causing allergies. It can accelerate the penetration of other actives into the skin. Squalane is a high-grade cosmetic oily raw materials, such as various types of creams and lotions, eyeliners, eyeshadow and conditioner. Cosmetics is mostly natural product extracted directly from cod liver oil. Synthetic products have stimulating effect on the human body, only used as lubricants and UV agents.
  3. Squalane is the most commonly used standard non-polar fixative with its polarity being set to zero. Such fixed liquid and component molecules is the dispersion force, mainly used for the separation of general hydrocarbons and non-polar compounds.


  1. It can be refined directly from the cod liver oil with refinement the first vacuum decompression obtained crude squalane, and then in the nickel catalyst, high temperature, high pressure hydrogenation, remove the double bond part, and then vacuum distillation available.
  2. Synthesis method. Take isoprene as raw material; first apply chlorination of isoprene, generating methyl heptanone, followed by dehydrogenation to generate linalool; further apply linalool and geranyl acetone, finally generating squalane.
  3. Squalene can be used as raw material with direct hydrogenation to obtain it.
  4. Take olive oil as raw material, extract the squalene, and then perform hydrogenation to obtain it.
  5. Linalool can react with ethyl acetoacetate to generate 3, 7, 11-trimethyl-dodecane-6, 10-dien-1-yn-3-ol; further use cuprous oxide as a catalyst for oxidation and coupling, hydrogenation to obtain the finished product of squalane.

Cooling Experiment

This product at -55 ℃ without losing its liquidity. Test based on the freezing-point determination method. The thermometer used was a low flow point thermometer, glass bath D, and put into dry ice and acetone for cooling.

Chemical Properties

viscous colourless liquid


health foods


Squalane has been used: as solvent in the synthesis of Europium dibenzoylmethide triethylammonium, brightest known triboluminescent (TL) material;as lubricant for fatty acid surfactant films adsorbed on iron oxide surfaces


Lubricant, transformer oil. Ingredient of watch and chronometer oils. Perfume fixative. In pharmacy and cosmetics as skin lubricant, ingredient of suppositories, carrier of lipid-soluble drugs.


squalane is an excellent moisturizer and lubricant, it softens and smoothes the skin while also replenishing skin lipids. Its compatibility with skin lipids can be attributed to the fact that human sebum is made up of 25 percent squalane. Squalane has traditionally been obtained by hydrogenation of shark liver oil or other natural oils. Components found in fish oils may reduce skin irritation and allergic responses. It can also be derived from plant sources or synthetically manufactured.


A saturated hydrocarbon.

Purification Methods

Purify squalane by fractional distillation in vacuo or evaporative distillation. It is soluble in pet ether, *C6H6, Et2O and CHCl3, slightly soluble in alcohols, Me2CO and AcOH but insoluble in H2O. Small quantities can be purified by TLC as for squalene below. It is used as a marker in GLC and HPLC. [Staudinger & Leupold Helv Chim Acta 15 223 1932, Sax & Stross Anal Chem 29 1700 1951, Mandai et al. Tetrahedron Lett 22 763 1981, Beilstein 1 IV 593.]

Squalane Preparation Products And Raw materials

Raw materials

Preparation Products

Squalane Suppliers

Global( 253)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037 CHINA 3000 58
Hebei Yime New Material Technology Co., Ltd.
031188129959 CHINA 98 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 whatapp+8619930503282
86-0311-66562153 CHINA 3124 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22609 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8874 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
Hebei Chisure Biotechnology Co.LTD
13292891350 +86 13292890173 CHINA 1010 58
career henan chemical co
+86-371-86658258 CHINA 29992 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691 CHINA 297 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58

View Lastest Price from Squalane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-12-03 Squalane Cosmetic Grade
US $100.00 / KG 1KG 99 5tons Hebei Chisure Biotechnology Co.LTD
2021-05-14 Squalane oil
US $58.00 / KG 1KG 99% 1000kg Hebei Yime New Material Technology Co., Ltd.
2021-04-01 Squalane
US $0.00 / Kg/Drum 1KG 99.9% 100000kg per month Wuhan Mulei New Material Technology Co. Ltd

Squalane Spectrum

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