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N-TERT-BUTYL-ALPHA-PHENYLNITRONE

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Structure
N-TERT-BUTYL-ALPHA-PHENYLNITRONE structure
CAS No.
3376-24-7
Chemical Name:
N-TERT-BUTYL-ALPHA-PHENYLNITRONE
Synonyms
PBN;N-tert-Butyl-α-phenylnitrone;N-tert-Butyl-α-phenylnitrone;2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide;Butylphenylnitrone;Phenyl N-t-butylnitrone;PHENYL-TERT-BUTYLNITRONE;N-T-BUTYL-A-PHENYLNITRONE;PHENYL N-TERT-BUTYLNITRONE;c-phenyl-n-tert-butylnitrone
CBNumber:
CB8469861
Molecular Formula:
C11H15NO
Molecular Weight:
177.24
MDL Number:
MFCD00008799
MOL File:
3376-24-7.mol
Last updated:2023-12-27 17:40:21
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Properties

Melting point 73-74 °C(lit.)
Boiling point 283℃
Density 0.990
refractive index 1.5480 (estimate)
Flash point 119℃
storage temp. Store at <= 20°C.
solubility DMSO: soluble
form powder
pka 1.50±0.53(Predicted)
color white
Water Solubility Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
Merck 14,7056
BRN 2044028
CAS DataBase Reference 3376-24-7(CAS DataBase Reference)
FDA UNII 3I91332OPG
EPA Substance Registry System 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3
RTECS  TX1760000
F  10
TSCA  Yes
HS Code  2929 90 00
NFPA 704
0
1 0

N-TERT-BUTYL-ALPHA-PHENYLNITRONE price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 80126 N-tert-Butyl-α-phenylnitrone for ESR-spectroscopy 3376-24-7 1g $281 2024-03-01 Buy
Sigma-Aldrich 8.41179 N-tert-Butyl-α-phenylnitrone for synthesis 3376-24-7 1g $132 2024-03-01 Buy
Sigma-Aldrich 203995 N-tert-Butyl-α-phenylnitrone Most commonly-used free radical trap. 3376-24-7 500mg $111 2024-03-01 Buy
TCI Chemical B1701 N-tert-Butyl-alpha-phenylnitrone >98.0%(HPLC)(T) 3376-24-7 1g $68 2024-03-01 Buy
TCI Chemical B1701 N-tert-Butyl-alpha-phenylnitrone >98.0%(HPLC)(T) 3376-24-7 5g $218 2024-03-01 Buy
Product number Packaging Price Buy
80126 1g $281 Buy
8.41179 1g $132 Buy
203995 500mg $111 Buy
B1701 1g $68 Buy
B1701 5g $218 Buy

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Chemical Properties,Uses,Production

Chemical Properties

white to light beige fine crystalline powder

Uses

N-tert-Butyl-α-phenylnitrone has been used:

  • as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
  • as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
  • to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)

Uses

Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.

Uses

N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Synthesis Reference(s)

Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6

General Description

Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Biochem/physiol Actions

Product does not compete with ATP.

Purification Methods

Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.]

N-TERT-BUTYL-ALPHA-PHENYLNITRONE synthesis

3378-72-1
3376-24-7
Synthesis of N-TERT-BUTYL-ALPHA-PHENYLNITRONE from N-(tert-Butyl)benzylamine

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Preparation Products And Raw materials

Raw materials

ZINC Acetonitrile Ethanol Sodium sulfate Toluene
3-Chloroperoxybenzoic acid Benzaldehyde Diethyl ether Benzene Ethyl acetate
Hydrochloric acid Sodium bicarbonate Potassium permanganate Acetic acid tert-Butylamine
PETROLEUM ETHER

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Preparation Products

2-METHYL-N-(PHENYLMETHYLENE)-2-PROPYLAMINE N-tert-butylhydroxylamine

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Suppliers

Global( 153)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 6710 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Supplier Advantage
Shanghai UCHEM Inc. 		58
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58

View Lastest Price from N-TERT-BUTYL-ALPHA-PHENYLNITRONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-tert-Butyl-α-phenylnitrone pictures 2024-02-23 N-tert-Butyl-α-phenylnitrone
3376-24-7
 US $79.00-519.00 / g 5g 0.97 25kg Shanghai UCHEM Inc.
3376-24-7 pictures 2019-07-06 3376-24-7
3376-24-7
 US $1.00 / KG 1KG 98% 1kg,5kg,100kg Career Henan Chemical Co
  • 3376-24-7 pictures
  • 3376-24-7
    3376-24-7
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Spectrum

N-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)MSN-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)1HNMRN-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)13CNMRN-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)IR1N-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)IR2N-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)RamanN-TERT-BUTYL-ALPHA-PHENYLNITRONE(3376-24-7)ESR

3376-24-7(N-TERT-BUTYL-ALPHA-PHENYLNITRONE)Related Search:

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine N-TERT-BUTYL-ALPHA-PHENYLNITRONE tert-Butylamine NITRON
PTIO CARBOXY-PTIO 2-(4-NITROPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL N-TERT-BUTYL-D9-PHENYL-D5-NITRONE N-TERT-BUTYL-ALPHA-(2-SULFOPHENYL)NITRO&
BENZYLIDENE(2-HYDROXYIMINO-1,1-DIMETHYLETHYL)AMMONIUMOLATE N-(1-CYANO-1-METHYLETHYL)-A-PHENYLNITRONE 5-AMINO-4,4-DIMETHYL-2-PHENYL-4H-IMIDAZOLE-3-OXIDE 2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, NA N-TERT-BUTYL-ALPHA-(2,4,6-TRIMETHOXY-PHENYL)NITRONE, 99
1H-IMIDAZOL-1-YLOXY, 2-(1,3-BENZODIOXOL-5-YL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-, 3-OXIDE 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 3,3,4,4-TETRAMETHYL-2-TRIMETHYLAMMONIOPHENYL-2-IMIDAZOLINE-3-OXIDE-1-YLOXY CHLORIDE

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c-phenyl-n-tert-butylnitrone n-benzylidene-tert-butylamineoxide n-tert-butyl-2-phenylnitrone n-tert-butyl-alpha-phenyl-nitron n-tert-butyl-c-phenylnitrone (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide PHENYL N-TERT-BUTYLNITRONE N-BENZYLIDENE-TERT-BUTYLAMINE N-OXIDE N-T-BUTYL-ALPHA-PHENYLNITRONE N-TERT-BUTYL-ALPHA-PHENYLNITRONE N-TERT-BUTYL-A-PHENYLNITRONE BENZYLIDENE(TERT-BUTYL)AMMONIUMOLATE Phenyl N-t-butylnitrone Butylphenylnitrone N-benzyliden-tert-butylamine N-ether N-T-BUTYL-A-PHENYLNITRONE N-TERT-BUTYL-ALPHA-PHENYLNITRONE (PNB) à-phenyl-n-tert-butylnitrone n-tert-butyl-à-phenylnitrone PHENYL-TERT-BUTYLNITRONE N-tert-Butyl-ɑ-phenylnitrone, 98% N-tert-B-butyl-alpha-phenylnitrone,98% 2-Methyl-N-(phenylmethylene)-2-propanamine N-oxide 2-Methyl-N-(phenylmethylene)-2-propanamine oxide N-tert-Butyl-alpha-phenylnitrone,98% N-tert-Butyl-α-phenylnitrone ,98% N-tert-Butyl-α-phenylnitrone,N-Benzylidene-tert-butylamine N-oxide, PBN, Phenyl N-t-butylnitrone 2-methyl-n-(phenylmethylene)-2-propanaminn-oxide 2-methyl-n-(phenylmethylene)-s-propanaminen-oxide 2-methyl-n-(phenylmethylene)-s-propanaminn-oxide 2-phenyl-n-tert-butylnitrone alpha-phenyl-n-tert-butylnitrone Benzylidene(tert-butyl)azane oxide benzylidene-tert-butylaminen-oxide N-tert-Butyl-alpha-phenylnitrone, 98% 5GR Benzylidene-tert-butylamine oxide tert-Butyl(benzylidene)amine N-oxide N-tert-Butyl-α-phenylnitrone(PBN) N-tert-Butyl-α-phenylnitrone - CAS 3376-24-7 - Calbiochem N-Benzylidene-2-methylpropan-2-amine oxide N-tert-Butyl-alpha-phenylnitrone> N-TERT-BUTYL-A-PHENYLNITRONE FOR SYNTHES (E)-tert-butyl(oxido)(phenylmethylidene)azanium N-benzylidene-t-butylamine N-oxide N-tert-Butyl-α-phenylnitrone, 95%+ PBN N-tert-Butyl-α-phenylnitrone 2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide N-tert-Butyl-α-phenylnitrone N-benzylidene-2-methylpropane-2-amine oxide N-tert-Butyl-α-phenylnitrone(PBN) 3376-24-7 C6H5CHNOCCH33 Biochemicals and Reagents BioChemical Cell Signaling Enzymes Application Index Stable Radicals