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(+)-N-METHYLEPHEDRINE

CAS No.
42151-56-4
Chemical Name:
(+)-N-METHYLEPHEDRINE
Synonyms
d-Methylephedrine;d-N-Methylephedrine;(+)-N-METHYLEPHEDRINE;(+)-N-METHYLEPHEDRINE;(+)-N-METHYLEPHEDRINE 98%;(1S,2R)-(+)-N-METHYLEPHEDRINE;L-(+)-erythro-N-Methylephedrine;(IS,2R)-d-N-Methylephedrine Base;(+)-(1S,2R)-2-DIMETHYLAMINO-1-PHENYLPROPANOL;(1S,2R)-1-Phenyl-2-(dimethylamino)-1-propanol
CBNumber:
CB8474995
Molecular Formula:
C11H17NO
Molecular Weight:
179.26
MDL Number:
MFCD00064259
MOL File:
42151-56-4.mol
Last updated:2023-05-04 15:16:24

(+)-N-METHYLEPHEDRINE Properties

Melting point 87-90 °C(lit.)
Boiling point 311.8°C (rough estimate)
Density 1.0020 (rough estimate)
refractive index 1.5320 (estimate)
storage temp. 2-8°C
pka 13.88±0.20(Predicted)
optical activity [α]20/D +29°, c = 5 in methanol
BRN 3198945
FDA UNII VP306Z33KI

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
3
NFPA 704
0
2 1

(+)-N-METHYLEPHEDRINE Chemical Properties,Uses,Production

Chemical Properties

WHITE CRYSTALLINE POWDER

Purification Methods

N-Methylephedrine has been recrystallised from Et2O, pet ether, of aqueous EtOH or aqueous MeOH and has been distilled under reduced pressure. [Smith J Chem Soc 2056 1927, Tanaka & Sugawa Yakugaku Zasshi (J Pharm Soc Japan) 72 1548 1952 (Chem Abstr 47 8682 1953), Takamatsu Yakugaku Zasshi (J Pharm Soc Japan) 76 1227 1956, Chem Abstr 51 4304 1957.] The hydrochloride has m 192-193o and [] D (c 5,H2O)[Prelog & Hüfliger Helv Chim Acta 33 2021 1950].20+30o [Beilstein 13 IV 1884.]

(+)-N-METHYLEPHEDRINE Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-N-METHYLEPHEDRINE (+)-(1S,2R)-2-DIMETHYLAMINO-1-PHENYLPROPANOL (1S,2R)-(+)-N-METHYLEPHEDRINE Benzenemethanol, α-[(1R)-1-(dimethylamino)ethyl]-, (αS)- Benzenemethanol, α-[1-(dimethylamino)ethyl]-, [S-(R*,S*)]- d-N-Methylephedrine L-(+)-erythro-N-Methylephedrine (+)-N-METHYLEPHEDRINE 98% (+)-(1S,2R)-2-Dimethylamino-1-phenylpropanol, (+)-N-Methylephedrine (1S,2R)-1-Phenyl-2-(dimethylamino)-1-propanol (S)-α-[(R)-1-(Dimethylamino)ethyl]benzenemethanol [1S,2R,(+)]-2-(Dimethylamino)-1-phenyl-1-propanol d-Methylephedrine (1R,2S)-2-(DiMethylaMino)-1-phenylpropan-1-ol (IS,2R)-d-N-Methylephedrine Base (+)-N-METHYLEPHEDRINE 42151-56-4 C11H17NO Ephedrine Derivatives Asymmetric Synthesis Chiral Auxiliaries