4,6-Dichloro-5-fluoropyrimidine
- CAS No.
- 213265-83-9
- Chemical Name:
- 4,6-Dichloro-5-fluoropyrimidine
- Synonyms
- 6-Dichloro-5-fluoropyriMidine;4,6-Dichloro-5-Fluoro Pyridine;4,6-DICHLORO-5-FLUORO-PYRIMIDINE;4,6-Dichloro-5-fluoro-1,3-diazine;4,6-Dichloro-5-fluoropyriMidinene;Pyrimidine, 4,6-dichloro-5-fluoro-;4,6-Dichloro-5-fluoropyrimidine,98%;4,6-Dichloro-5-fluoropyrimidine ISO 9001：2015 REACH
- CBNumber:
- CB8475240
- Molecular Formula:
- C4HCl2FN2
- Molecular Weight:
- 166.97
- MDL Number:
- MFCD08056331
- MOL File:
- 213265-83-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4,6-Dichloro-5-fluoropyrimidine | D437193 | 1g | $70 |
| 4,6-Dichloro-5-fluoropyrimidine | 3H32-7-87 | 250mg | $75 |
| 4,6-Dichloro-5-fluoropyrimidine >96% | 059861 | 5g | $60 |
| 4,6-Dichloro-5-fluoropyrimidine | FD11921 | 1g | $65 |
| 4,6-Dichloro-5-fluoropyrimidine | PC51025 | 1g | $70 |
| More product size | |||
| Boiling point | 50-60℃/14mm |
|---|---|
| Density | 1.605±0.06 g/cm3(Predicted) |
| Flash point | 91°(196°F) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO, Methanol (Slightly) |
| form | Liquid |
| pka | -5.42±0.26(Predicted) |
| color | Colourless |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C4HCl2FN2/c5-3-2(7)4(6)9-1-8-3/h1H |
| InChIKey | DGMIGAHDDPJOPN-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=C(F)C(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H314-H318 | |||||||||
| Precautionary statements | P210e-P260h-P303+P361+P353-P305+P351+P338-P405-P501a | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | UN3265 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29335990 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4,6-Dichloro-5-fluoropyrimidine price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D437193 | 4,6-Dichloro-5-fluoropyrimidine | 213265-83-9 | 1g | $70 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-7-87 | 4,6-Dichloro-5-fluoropyrimidine | 213265-83-9 | 250mg | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 059861 | 4,6-Dichloro-5-fluoropyrimidine >96% | 213265-83-9 | 5g | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD11921 | 4,6-Dichloro-5-fluoropyrimidine | 213265-83-9 | 1g | $65 | 2021-12-16 | Buy |
| Apolloscientific | PC51025 | 4,6-Dichloro-5-fluoropyrimidine | 213265-83-9 | 1g | $70 | 2021-12-16 | Buy |
4,6-Dichloro-5-fluoropyrimidine Chemical Properties,Uses,Production
Uses
4,6-Dichloro-5-Fluoropyrimidine is an useful intermediate for pharmaceuticals.
Synthesis
106615-61-6
213265-83-9
General procedure for the synthesis of 4,6-dichloro-5-fluoropyrimidine from 5-fluoro-4,6-dihydroxypyrimidine (Method B): phosphoryl chloride (0.593 L, 6.376 mol) was slowly added to a 2 L three-necked round-bottomed flask containing 5-fluoropyrimidine-4,6-diol (276.459 g, 2.125 mol) to form a slurry at room temperature. N,N-dimethylaniline (81 mL, 0.638 mol) was slowly added to this slurry through the addition funnel and the reaction was exothermic. The reaction mixture was continued to be stirred at 110°C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into a 2 L mixture consisting of brine and ice under stirring. The aqueous layer (showing red color) was extracted with dichloromethane (2 x 2 L). The organic layers were combined and washed sequentially with cold 6 N hydrochloric acid (2 × 1 L, showing honey brown color) and saturated sodium bicarbonate solution (1 L). The organic layer was dried with anhydrous sodium sulfate, filtered through glass fiber paper under vacuum, and concentrated under reduced pressure (without heating) to afford 4,6-dichloro-5-fluoropyrimidine (CAS No. 213265-83-9, 347.9 g, 2.084 mol, 98% yield) as an amber colored oil. Nuclear magnetic resonance (NMR) analysis showed traces of dichloromethane in the product. 4,6-Dichloro-5-fluoropyrimidine (420 g, 2.515 mol) was subjected to vacuum distillation, and the fraction with a boiling point of 35°C (pressure 1 torr) was collected to give a colorless oily substance (332.574 g, 1.992 mol, 79% yield). The product solidified at -78°C and remelted to liquid at room temperature. Distillation conditions: oil bath temperature 100°C; product boiling point 35°C; pressure 1 Torr. 1H NMR (400 MHz, DMSO-d6) δ 8.8 (s, 1H).
References
[1] Patent: WO2012/40279, 2012, A1. Location in patent: Page/Page column 86
[2] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 11
[3] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 12
[4] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 10
4,6-Dichloro-5-fluoropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Guiren Medicine Co.,Ltd | +86-13815020719 | guiren_medicine@163.com | China | 212 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 4,6-Dichloro-5-fluoropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
|
US $8.00-0.80 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-06-25 | 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
- US $8.00-0.80 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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