eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

CAS No.
304475-63-6
Chemical Name:
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
Synonyms
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem;InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem;2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-
CBNumber:
CB84813855
Molecular Formula:
C21H17Cl3N4OS
Molecular Weight:
479.81
MDL Number:
MOL File:
304475-63-6.mol
Last updated:2023-05-09 09:30:53

eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Properties

Density 1.474±0.06 g/cm3(Predicted)
pka 10.70±0.70(Predicted)
FDA UNII J8PSF5Z8KJ

eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 324897 InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem 304475-63-6 5mg $259 2024-03-01 Buy
Sigma-Aldrich 324895 eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem 304475-63-6 5mg $230 2024-03-01 Buy
Product number Packaging Price Buy
324897 5mg $259 Buy
324895 5mg $230 Buy

eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 μM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 μM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.

Biochem/physiol Actions

Cell permeable: yes

eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem 2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]- 304475-63-6