Anti-BICD2 Antibody
- CAS No.
- Chemical Name:
- Anti-BICD2 Antibody
- Synonyms
- Anti-BICD2 Antibody
- CBNumber:
- CB84815864
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-BICD2 Antibody price More Price(1)
Anti-BICD2 Antibody Chemical Properties,Uses,Production
Uses
Anti-BICD2 detects levels of BICD2 proteins & has been published & validated for use in WB & IHC.
General Description
BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
Anti-BICD2 Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-BICD2 Antibody Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |